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- the 18th letter of the Roman alphabet (同)r
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- resistance / 17歳以下父兄同伴映画の表示 / rook
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/04 19:54:35」(JST)
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- 1. HIV陰性患者における結核の診断 diagnosis of pulmonary tuberculosis in hiv negative patients
- 2. HIV陰性患者における肺結核の治療 treatment of pulmonary tuberculosis in hiv negative patients
- 3. HIV感染患者における結核の疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of tuberculosis in hiv infected patients
- 4. 肺外結核および粟粒結核の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of extrapulmonary and miliary tuberculosis
- 5. 薬剤耐性結核の診断、治療、および予防 diagnosis treatment and prevention of drug resistant tuberculosis
English Journal
- Rifampicin reduces advanced glycation end products and activates DAF-16 to increase lifespan in Caenorhabditis elegans.
- Golegaonkar S1, Tabrez SS, Pandit A, Sethurathinam S, Jagadeeshaprasad MG, Bansode S, Sampathkumar SG, Kulkarni MJ, Mukhopadhyay A.
- Aging cell.Aging Cell.2015 Jun;14(3):463-73. doi: 10.1111/acel.12327. Epub 2015 Feb 26.
- Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders. Thus, pharmaceutical intervent
- PMID 25720500
- Gene expression patterns combined with network analysis identify hub genes associated with bladder cancer.
- Bi D1, Ning H1, Liu S1, Que X1, Ding K2.
- Computational biology and chemistry.Comput Biol Chem.2015 Jun;56:71-83. doi: 10.1016/j.compbiolchem.2015.04.001. Epub 2015 Apr 15.
- OBJECTIVES: To explore molecular mechanisms of bladder cancer (BC), network strategy was used to find biomarkers for early detection and diagnosis.METHODS: The differentially expressed genes (DEGs) between bladder carcinoma patients and normal subjects were screened using empirical Bayes method of t
- PMID 25889321
- Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
- Chu X1, Shih SJ2, Shaw R2, Hentze H2, Chan GH2, Owens K2, Wang S2, Cai X2, Newton D2, Castro-Perez J2, Salituro G2, Palamanda J2, Fernandis A2, Ng CK2, Liaw A2, Savage MJ2, Evers R2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Jun;43(6):851-63. doi: 10.1124/dmd.115.063347. Epub 2015 Mar 26.
- Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for DDIs early in drug de
- PMID 25813937
Japanese Journal
- 史料紹介 : アフマド・イブン・ファドル・アッラー・ウマリー著『高貴なる用語の解説』訳注（4）
- 谷口 淳一,TANIGUCHI Junichi
- 史窓 070, 31-49, 2013-02-08
- NAID 120005284916
- エフォートフル・コントロールは検索誘導性忘却を予測する
- 小林 正法,丹野 義彦
- パーソナリティ研究 22(1), 77-79, 2013
- … Retrieval of a memory can cause forgetting of other related memories, which is known as retrieval-induced forgetting (RIF). … This study investigated whether individual differences in effortful control (EC), which reflects executive function ability, predict RIF. … The results showed that EC was positively correlated with RIF, even when dysphoria and trait-anxiety were controlled. …
- NAID 130003363155
- In Vitro Antimicrobial Susceptibility of Brucella melitensis Isolates from Sheep in an Area Endemic for Human Brucellosis in Turkey
- ILHAN Ziya,SOLMAZ Hasan,EKIN Ismail Hakkı
- Journal of Veterinary Medical Science, 2013
- … The aim of this study was to assess in vitro antimicrobial susceptibility of Brucella melitensis isolates isolated from naturally infected sheep cases in an area where human brucellosis is endemic, focusing on rifampin (RIF), streptomycin (SM), ciprofloxacin (CPFX), trimethoprim/sulfamethoxazole (TMP/SMZ), gentamicin (GM) and tetracycline (TC), and on 11 other antimicrobials. … The resistance to SM, CPFX and GM was determined at the rate of 7.3%, and to RIF at the rate of 9.7%. …
- NAID 130003362161
Related Links
- Reading Is Fundamental (RIF) is the nation's largest nonprofit children's literacy organization. Through RIF programs, we prepare and motivate children to read by delivering free books and literacy resources to children who need them most.
Related Pictures
★リンクテーブル★
| リンク元 | 「リファンピシン」「rifampicin」 |
| 拡張検索 | 「RIFLE分類」「ORIF」「SRIF」 |
| 関連記事 | 「RI」「R」 |
「リファンピシン」
分類
- 抗結核薬
特徴
- 濃度依存性 ← アミノグリコシドlike
- 血漿濃度より組織内の方が高濃度に分布し、マクロファージに潜伏する結核菌に有効に作用。
薬理作用
- 抗菌作用：結核菌に対する抗菌力はイソニアジドに匹敵。
作用機序
- 結核菌のDNA依存RNAポリメラーゼに作用し、RNA合成初期段階を阻害(参考2)
注意
副作用
- 他の抗結核菌薬と比べて特異的なものはない。
- 白血球減少、血小板減少、発疹、肝障害
- 参考1
- 胃腸症状(悪心、嘔吐、下痢)、中枢神経系(頭痛、発熱)、皮膚(皮疹、掻痒、発赤)、血液系の異常(血小板減少症、急性溶血性貧血)
- イソニアジドなどの肝毒性を有する薬剤との同時投与により肝炎を来しやすい。
- 掻痒症も来すことがある。観血的に高用量を用いた患者にインフルエンザ様症状出現の報告がある。
- 体液(汗、唾液、涙)がオレンジ～橙赤色になる。
参考
- 1. [charged] Rifampin and other rifamycins - uptodate
- 2. リファジンカプセル１５０ｍｇ - 添付文書
「rifampicin」
「RIFLE分類」
- 第2回ADQIカンファレンス(2002年イタリア・ビチェンツア)で新たに提唱された急性腎不全の診断・分類・重症度の分類
- Risk, Injury, Failure, Loss of kidney function and End stage of kidney disease という視点で分類。
| GFR による診断 | 尿流量による診断 | |
| リスク（R） | 血清クレアチニン値×1.5＜ or GFR 低下＞25 ％ |
尿流量＜0.5 ml/kg/hr×6 hr |
| 障害（I） | 血清クレアチニン値×2＜ or GFR 低下＞50 ％ |
尿流量＜0.5 ml/kg/hr×12 hr |
| 機能不全（F） | 血清クレアチニン値×3＜ or GFR 低下＞75 ％， or 血清クレアチニン値≧4 mg/dl で 0.5 mg/dl の急性上昇を伴う |
尿流量＜0.3 ml/kg/hr×24 hr 無尿×12 hr （Anuria×12 hrs） |
| 腎機能喪失（L） | 4 週以上持続する急性腎不全 | |
| 末期腎不全（E） | 3 カ月以上回復しない腎不全 | |
参考
- 1.
- 2. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
- Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative workgroup.SourceDepartment of Intensive Care and Medicine, Austin Health, Melbourne, Australia. rinaldo.bellomo@austin.org.au
- Critical care (London, England).Crit Care.2004 Aug;8(4):R204-12. Epub 2004 May 24.
- INTRODUCTION: There is no consensus definition of acute renal failure (ARF) in critically ill patients. More than 30 different definitions have been used in the literature, creating much confusion and making comparisons difficult. Similarly, strong debate exists on the validity and clinical relevanc
- PMID 15312219
「ORIF」
[★] 観血的整復固定術 open reduction and internal fixation
「SRIF」
「RI」
- 放射性同位元素 ラジオアイソトープ radioisotope
- ローレル指数 Rohrer's index
- ロードアイランド州 Rhode Island
- 網状赤血球指数 reticulocyte index
「R」