English Journal

Gruszynski AE, DeMaster A, Hooper NM, Bangs JD.SourceDepartment of Biomolecular Chemistry, University of Wisconsin Medical School, Madison 53706, USA.
The Journal of biological chemistry.J Biol Chem.2003 Jul 4;278(27):24665-72. Epub 2003 Apr 25.
African trypanosomes (Trypanosoma brucei) are digenetic parasites whose lifecycle alternates between the mammalian bloodstream and the midgut of the tsetse fly vector. In mammals, proliferating long slender parasites transform into non-diving short stumpy forms, which differentiate into procyclic fo
PMID 12716904

[Pharmacological and clinical properties of beraprost sodium, orally active prostacyclin analogue].

Nishio S, Kurumatani H.SourcePharmaceutical Research Laboratories, Toray Industries Inc., 1111 Tebiro, Kamakura, Kanagawa 248-8555, Japan. Shintaro Nishio@nts.toray.co.jp
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.Nihon Yakurigaku Zasshi.2001 Feb;117(2):123-30.
Prostacyclin is an endogeneous eicosanoid synthesized by vascular endothelial cells, and has potent inhibitory effects on platelet adhesion/aggregation and vasoconstriction. However, its therapeutic use is restricted by its extremely short half-life. Beraprost sodium (beraprost) is the first orally
PMID 11233303

Japanese Journal

AKIMOTO Ruri,MISHIMA Emi,WATANABE Tetsuro,CHINEN Taeko,MIYASAKA Keiichi,WASHIZAKI Kumiko,YOSHIDA Masami,ITOH Masatoshi
Environmental dermatology : the official journal of the Japanese Society for Contact Dermatitis 10(3), 95-100, 2003-07-01
NAID 50000351445

西尾伸太郎,車谷元
日本薬理学雑誌 117(2), 123-130, 2001-02-01
プロスタサイクリン(PGI<SUB>2</SUB>)は主に血管内皮細胞で合成される内因性のエイコサノイドであり, 血小板の粘着/凝集や血管の収縮に対して強力な抑制作用を有している.しかしながら, その半減期が極めて短いために治療薬としての使用は静脈注射に限られていた.ベラプロストナトリウム(以下ベラプロスト)は, 世界ではじめての経口投与可能なPGI<SUB>2 …
NAID 10007365549