関: propantheline、propantheline bromide

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in favor of a proposition, opinion, etc.
an argument in favor of a proposal
in favor of (an action or proposal etc.); "a pro vote"
the 16th letter of the Roman alphabet (同)p

PrepTutorEJDIC

=professional
賛成論;賛成票(者) / 賛成して
parking
phosphorusの化学記号
Provencal
praseodymiumの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/13 02:44:14」(JST)

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Propantheline bromide (INN) is an antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of TCAs. ^[1]

Indications

By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.

Adverse effects

Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By taking this medication it becomes easier to do "dry" dentistry

Mechanism of action

Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.

References

^ Vasavada, Sandip P.; Appell, Rodney; Sand, Peter K.; Raz, Shlomo (2004). Female Urology, Urogynecology, and Voiding Dysfunction. Informa Health Care. ISBN 0-8247-5426-3.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

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English Journal

[Propantheline bromide is effective against dog drooling].

Gyldenløve M1, Thyssen JP.
Ugeskrift for laeger.Ugeskr Laeger.2015 Dec 21;177(52). pii: V67934.
Hyperhidrosis is a common condition characterized by extensive sweat secretion. Systemic treatment with anticholinergics might prove effective, but patients often suffer from side effects, e.g. dryness of the mouth. We present a clinical case of severe polydipsia in a six-month-old puppy who had acc
PMID 26692220

Flavoxate: present and future.

Arcaniolo D1, Conquy S, Tarcan T.
European review for medical and pharmacological sciences.Eur Rev Med Pharmacol Sci.2015;19(5):719-31.
OBJECTIVE: This non-systematic review discusses the available evidence on the use of flavoxate in the treatment of overactive bladder (OAB).METHODS: Medline was searched for inclusion of relevant studies. No limitations in time were considered.RESULTS: Flavoxate hydrochloride is an antispasmodic age
PMID 25807422

Novel strategy for online monitoring of the degradation kinetics of propantheline bromide via a calixarene-based ion-selective electrode.

Abd El-Rahman MK1, Zaazaa HE1, Badr ElDin N2, Moustafa AA1.
Talanta.Talanta.2015 Jan;132:52-8. doi: 10.1016/j.talanta.2014.08.068. Epub 2014 Sep 6.
Propantheline bromide (PB) is a hydrolysable anti-cholinergic drug. A novel strategy for the online monitoring of PB degradation kinetics catalysed by hydroxyl ions is presented. This is achieved by the incorporation of an on-site PB-selective electrode constructed using as an ionophore. This sensor
PMID 25476278

Japanese Journal

Pro-Banthine P.A.錠による消化性潰瘍の治療経験

横田穣 [他]
臨牀と研究 41(2), ????, 1964-02
NAID 40018613233

胃十二指腸潰瘍に対するPro-Banthineの臨牀効果

山形敞一 [他]
臨床の日本 3(10), ????, 1957-10
NAID 40018618614

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Pro-banthine Tablets 15mg - 112 tabs Pro-Banthine 15mg 100 Tablets/Pack picture alternative for pro-banthine name pro banthine pro banthine is used for Pro-Banthine）の個人輸入代行 home conditions gastro health pro banthine

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リンク元	「プロパンテリン」
関連記事	「P」「pro」「Pr」

「プロパンテリン」

Propantheline bromide
Systematic (IUPAC) name
	N-isopropyl-N-methyl-N-{2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl}propan-2-aminium bromide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a684020
Legal status	?
Identifiers
CAS number	298-50-0 50-34-0
ATC code	A03AB05
PubChem	CID 9279
IUPHAR ligand	329
DrugBank	DB00782
ChemSpider	8922
UNII	1306V2B0Q8
ChEMBL	CHEMBL1240
Chemical data
Formula	C23H30NO3
Mol. mass	368.489 g/mol
	SMILES [Br-].O=C(OCC[N+](C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3;
	InChI InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 ; Key:XLBIBBZXLMYSFF-UHFFFAOYSA-M ;
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