WordNet

any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs

PrepTutorEJDIC

〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/24 13:50:03」(JST)

wiki en

Propantheline bromide (INN) is an antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of TCAs. ^[1]

Indications

By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.

Adverse effects

Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By taking this medication it becomes easier to do "dry" dentistry

Mechanism of action

Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.

References

^ Vasavada, Sandip P.; Appell, Rodney; Sand, Peter K.; Raz, Shlomo (2004). Female Urology, Urogynecology, and Voiding Dysfunction. Informa Health Care. ISBN 0-8247-5426-3.

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 化学療法に関連した経口毒性 oral toxicity associated with chemotherapy
2. パーキンソン病の薬理学的治療 pharmacologic treatment of parkinson disease
3. 重症筋無力症の治療 treatment of myasthenia gravis
4. 女性における尿失禁の治療および予防 treatment and prevention of urinary incontinence in women
5. 軽症～中等症の潰瘍性大腸炎のマネージメント management of mild to moderate ulcerative colitis

English Journal

Prevention of oral mucositis in children receiving cancer therapy: A systematic review and evidence-based analysis.

Qutob AF, Gue S, Revesz T, Logan RM, Keefe D.SourceFaculty of Dentistry, King Abdulaziz University, P.O. Box 80209, Jeddah 21589, Saudi Arabia; School of Dentistry, Faculty of Health Sciences, The University of Adelaide, Frome Rd., Adelaide, SA 5005, Australia; Department of Paediatric Dentistry, The Women's and Children's Hospital, 72 King William Rd., North Adelaide, SA 5006, Australia.
Oral oncology.Oral Oncol.2012 Sep 6. [Epub ahead of print]
This systematic review investigated, critically appraised, and rated the evidence on agents used to prevent oral mucositis in children. A comprehensive search of the relevant literature was performed up to December 2011. Articles were included according to the inclusion/exclusion criteria and were c
PMID 22959949

The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses.

Sundra TM, Harrison JL, Lester GD, Raidal SL, Phillips JK.SourceSchool of Veterinary and Biomedical Science, Faculty of Health Sciences, Murdoch University, Perth, 6150 WA, Australia.
Research in veterinary science.Res Vet Sci.2012 Jun 8. [Epub ahead of print]
The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180min after treatment with propantheline (
PMID 22683390

Japanese Journal

Propantheline Attenuates the Peripheral Side Effects of Donepezil without Affecting Its Antiamnestic Properties in Cerebral Ischemic Mice

Fu Fenghua,Zhu Mei,Zhang Ying,Zhang Xiumei
Journal of health science 54(4), 409-415, 2008-08-01
… To investigate how to attenuate the peripheral side effects of CHI agents without affecting their efficacy, the effects of propantheline bromide (PB) co-administered with donepezil on the gastric emptying (GE), gastrointestinal transit (GIT), brain cholinesterase (ChE) activities, and maze tasks of mice with memory impairment induced by transient ischemia were observed. …
NAID 110006835686

Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes

FUNASAKI Noriaki,URATSUJI Ikumi,OKUNO Takashi,HIROTA Shun,NEYA Saburo
Chemical & pharmaceutical bulletin 54(8), 1155-1161, 2006-08-01
… The masking mechanisms of the bitter taste of propantheline bromide (PB) and oxyphenonium (OB) bromide by native and modified cyclodextrins, saccharides, surfactants, organic acids, nonionic and anionic polymers, and other compounds were investigated with ion selective electrodes. …
NAID 110004847235

Related Pictures

★リンクテーブル★

リンク元	「プロパンテリン」「Pro-Banthine」
関連記事	「bromide」「bromides」

「プロパンテリン」

Propantheline bromide
Systematic (IUPAC) name
	N-isopropyl-N-methyl-N-{2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl}propan-2-aminium bromide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a684020
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	298-50-0 50-34-0
ATC code	A03AB05
PubChem	CID 9279
IUPHAR ligand	329
DrugBank	DB00782
ChemSpider	8922
UNII	1306V2B0Q8
ChEMBL	CHEMBL1240
Chemical data
Formula	C23H30NO3
Mol. mass	368.489 g/mol
	SMILES [Br-].O=C(OCC[N+](C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3;
	InChI InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 ; Key:XLBIBBZXLMYSFF-UHFFFAOYSA-M ;
(what is this?) (verify);