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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/07 13:05:36」(JST)

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Propantheline bromide (INN) is an antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions. This agent can also be used for patients who experience intense GI symptoms while tapering off of TCAs. ^[1]

Indications

By relaxing the gut muscle, propantheline can relieve pain in conditions caused by spasm of the muscle in the gut. Relaxing the smooth muscle in the bladder prevents the involuntary spasms that can allow leakage of urine from the bladder in the condition known as enuresis (involuntary urination in adults). Propantheline can also be used to treat excessive sweating because acetylcholine block also reduces secretions such as sweat and tears.

Adverse effects

Side effects include tachycardia, constipation, hypersensitivity to light, dry mouth, and urinary retention. This can also be prescribed by dentists for certain patients who salivate excessively. By taking this medication it becomes easier to do "dry" dentistry

Mechanism of action

Propantheline is one of a group of antispasmodic medications which work by blocking the action of the chemical messenger acetylcholine, which is produced by nerve cells, to muscarinic receptors present in various smooth muscular tissues, in places such as the gut, bladder and eye. Normally, the binding of acetylcholine induces involuntary smooth muscular contractions.

References

^ Vasavada, Sandip P.; Appell, Rodney; Sand, Peter K.; Raz, Shlomo (2004). Female Urology, Urogynecology, and Voiding Dysfunction. Informa Health Care. ISBN 0-8247-5426-3.

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English Journal

[Propantheline bromide is effective against dog drooling].

Gyldenløve M1, Thyssen JP.
Ugeskrift for laeger.Ugeskr Laeger.2015 Dec 21;177(52). pii: V67934.
Hyperhidrosis is a common condition characterized by extensive sweat secretion. Systemic treatment with anticholinergics might prove effective, but patients often suffer from side effects, e.g. dryness of the mouth. We present a clinical case of severe polydipsia in a six-month-old puppy who had acc
PMID 26692220

Flavoxate: present and future.

Arcaniolo D1, Conquy S, Tarcan T.
European review for medical and pharmacological sciences.Eur Rev Med Pharmacol Sci.2015;19(5):719-31.
OBJECTIVE: This non-systematic review discusses the available evidence on the use of flavoxate in the treatment of overactive bladder (OAB).METHODS: Medline was searched for inclusion of relevant studies. No limitations in time were considered.RESULTS: Flavoxate hydrochloride is an antispasmodic age
PMID 25807422

Novel strategy for online monitoring of the degradation kinetics of propantheline bromide via a calixarene-based ion-selective electrode.

Abd El-Rahman MK1, Zaazaa HE1, Badr ElDin N2, Moustafa AA1.
Talanta.Talanta.2015 Jan;132:52-8. doi: 10.1016/j.talanta.2014.08.068. Epub 2014 Sep 6.
Propantheline bromide (PB) is a hydrolysable anti-cholinergic drug. A novel strategy for the online monitoring of PB degradation kinetics catalysed by hydroxyl ions is presented. This is achieved by the incorporation of an on-site PB-selective electrode constructed using as an ionophore. This sensor
PMID 25476278

Japanese Journal

"抗コリン薬イミダフェナシンとジゴキシンに薬物間相互作用がないのは疑わしい"に対するレスポンス

NAKADE Susumu,OHNO Tomoya,OGAWA Mikio
Drug metabolism and pharmacokinetics 24(5), 486-487, 2009-10-25
NAID 10025724859

Suspected Differential Interactions of Digoxin with Imidafenacin and Propantheline ; Some Thoughts for Introspection

SRINIVAS Nuggehally R.
Drug metabolism and pharmacokinetics 24(2), 194-196, 2009-04-25
NAID 10025723351

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リンク元	「プロパンテリン」「Pro-Banthine」「プロパンセリン」
拡張検索	「propantheline bromide」

「プロパンテリン」

Propantheline bromide
Systematic (IUPAC) name
	N-isopropyl-N-methyl-N-{2-[(9H-xanthen-9-ylcarbonyl)oxy]ethyl}propan-2-aminium bromide
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a684020
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	298-50-0 50-34-0
ATC code	A03AB05
PubChem	CID 9279
IUPHAR ligand	329
DrugBank	DB00782
ChemSpider	8922
UNII	1306V2B0Q8
ChEMBL	CHEMBL1240
Chemical data
Formula	C23H30NO3
Mol. mass	368.489 g/mol
	SMILES [Br-].O=C(OCC[N+](C(C)C)(C(C)C)C)C2c3c(Oc1c2cccc1)cccc3;
	InChI InChI=1S/C23H30NO3.BrH/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22;/h6-13,16-17,22H,14-15H2,1-5H3;1H/q+1;/p-1 ; Key:XLBIBBZXLMYSFF-UHFFFAOYSA-M ;
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