妊娠関連血漿タンパク質A

関: pregnancy-associated plasma protein-A

WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

answer / ampere
personal assistant個人秘書 / public address [system]
arsenicの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/06 20:48:19」(JST)

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[Wiki en表示]

Pappalysin-1, also known as pregnancy-associated plasma protein A, is a protein encoded by the PAPPA gene in humans. PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome.^[5]^[6]

Function

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). PAPPA's proteolytic function is activated upon collagen binding. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes).^[6] For example, low PAPPA may be commonly seen in prenatal screening for Down syndrome.^[5] Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.

Interactions

Pregnancy-associated plasma protein A has been shown to interact with Major basic protein.^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182752 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028370 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ ^a ^b Breathnach FM, Malone FD (2007). "Screening for aneuploidy in first and second trimesters: is there an optimal paradigm?". Curr. Opin. Obstet. Gynecol. 19 (2): 176–82. doi:10.1097/GCO.0b013e3280895e00. PMID 17353686.
^ ^a ^b "Entrez Gene: PAPPA pregnancy-associated plasma protein A, pappalysin 1".
^ Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C (October 2000). "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor". J. Biol. Chem. 275 (40): 31128–33. doi:10.1074/jbc.M001384200. PMID 10913121.
^ Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C (January 2003). "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment". J. Biol. Chem. 278 (4): 2106–17. doi:10.1074/jbc.M208777200. PMID 12421832.
^ Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L (June 1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17): 12243–6. PMID 7685339.

External links

The MEROPS online database for peptidases and their inhibitors: M43.004

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UpToDate Contents

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1. First-trimester combined test and integrated tests for screening for Down syndrome and trisomy 18
2. 子癇前症の予測 prediction of preeclampsia
3. ダウン症の母体血清スクリーニングに関する臨床検査の問題 laboratory issues related to maternal serum screening for down syndrome
4. 胎盤早期剥離：臨床的特徴および診断 placental abruption clinical features and diagnosis
5. ダウン症候群：出生前スクリーニングの概要 down syndrome overview of prenatal screening

English Journal

Could first-trimester assessment of placental functions predict preeclampsia and intrauterine growth restriction? A prospective cohort study.

Abdel Moety GA1, Almohamady M1, Sherif NA1, Raslana AN1, Mohamed TF1, El Moneam HM1, Mohy AM2, Youssef MA3.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Feb;29(3):413-7. doi: 10.3109/14767058.2014.1002763. Epub 2015 Jan 16.
OBJECTIVE: To examine the role of first-trimester uterine artery Doppler, serum β-hCG and pregnancy-associated placental protein-A (PAPP-A) in prediction of preeclampsia and IUGR.METHODS: A total of 100 pregnant women in the 11-14 weeks' gestation were examined using uterine artery Doppler, serum �
PMID 25594239

Synthesis of 3-substituted isoindolin-1-ones via a tandem desilylation, cross-coupling, hydroamidation sequence under aqueous phase-transfer conditions.

Munoz SB1, Aloia AN, Moore AK, Papp A, Mathew T, Fustero S, Olah GA, Surya Prakash GK.
Organic & biomolecular chemistry.Org Biomol Chem.2016 Jan 7;14(1):85-92. doi: 10.1039/c5ob02187a. Epub 2015 Nov 27.
A simple and expedient method for the synthesis of 3-methylene-isoindolin-1-ones 4 under aqueous phase-transfer conditions has been developed. Starting from 2-iodobenzamides 1 and (silyl)alkynes, the products are obtained in high yields and short reaction times (30 min) with the use of inexpensive C
PMID 26611810

Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation.

O'Gorman N1, Wright D2, Syngelaki A1, Akolekar R3, Wright A2, Poon LC1, Nicolaides KH4.
American journal of obstetrics and gynecology.Am J Obstet Gynecol.2016 Jan;214(1):103.e1-103.e12. doi: 10.1016/j.ajog.2015.08.034. Epub 2015 Aug 19.
BACKGROUND: Preeclampsia affects approximately 3% of all pregnancies and is a major cause of maternal and perinatal morbidity and death. In the last decade, extensive research has been devoted to early screening for preeclampsia with the aim of reducing the prevalence of the disease through pharmaco
PMID 26297382

Japanese Journal

Association Between Plasma Pregnancy-Associated Plasma Protein A and Restenosis After Percutaneous Coronary Angioplasty

Li Xu-Ping,Zhou Sheng Hua,Tang Jian Jun,Liu Qi Ming,Fang Zheng Fei,Hu Xing Qun,Zhou Tao,Sheng Xiang Qian,Zhao Shui Ping
Circulation journal : official journal of the Japanese Circulation Society 72(5), 729-733, 2008-04-20
… This study evaluates the association between plasma pregnancy-associated plasma protein A (PAPP-A) levels and restenosis after coronary angioplasty. … Methods and Results Blood samples were collected from all patients at baseline, and their levels of PAPP-A, inflammation (high-sensitivity C-reactive protein (hsCRP)) and platelet activation (soluble CD40 ligand (sCD40L)) were determined. …
NAID 110006680550

妊娠関連血漿蛋白質A(PAPP-A)と胎盤増殖因子(PIGF)--急性冠症候群発症との関係 (第1土曜特集心血管マルチバイオマーカー・ストラテジー) -- (新規バイオマーカーの臨床展開)

江田信一
医学のあゆみ 224(5), 385-388, 2008-02-02
NAID 40015811181

Quality Assurance Challenges in X-ray Emission Based Analyses, the Advantage of Digital Signal Processing

Papp T.,Papp A. T.,Maxwell J. A.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 21(7), 737-745, 2005-07-10
NAID 10016579131

Related Pictures

Que signifie pour les PAPP-A? - PAPP-A papp-a freebetahcg -Associated Plasma Protein-A; PAPP-A 初期ママの血清マーカー(PAPP-A PAPP-A: Duda's Epic Quest To Epicness: PAPP-A

★リンクテーブル★

リンク元	「pregnancy-associated plasma protein-A」「妊娠関連血漿タンパク質A」
関連記事	「PA」「PAP」「A」「Ad」

「pregnancy-associated plasma protein-A」

PAPPA
Identifiers
Aliases	PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin 1
External IDs	OMIM: 176385 MGI: 97479 HomoloGene: 31097 GeneCards: PAPPA
Gene location (Human)
Chr.	Chromosome 9 (human)
End	116,402,322 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	65,357,509 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• zinc ion binding; • peptidase activity; • endopeptidase activity; • hydrolase activity; • metallopeptidase activity; • metal ion binding; • metalloendopeptidase activity;
Cellular component	• extracellular region; • extracellular space;
Biological process	• cellular protein metabolic process; • proteolysis; • response to follicle-stimulating hormone; • female pregnancy; • response to glucocorticoid;
	Sources:Amigo / QuickGO
Orthologs
	5069
	18491
	ENSG00000182752
	ENSMUSG00000028370
	Q13219
	Q8R4K8
	NM_002581
	NM_021362
	NP_002572
	NP_067337
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

(胎盤で生成される妊娠の生化学的マーカー)妊娠関連血漿タンパク質A

関: PAPP-A

「妊娠関連血漿タンパク質A」

　　[★]

英: pregnancy-associated plasma protein-A、PAPP-A

「PA」

　　[★]

微生物学：粒子凝集法(particle agglutination test)
薬理学：

「PAP」

　　[★]

「A」

　　[★]

「Ad」

　　[★]

アデノウイルス

関: adenoviral、adenovirus

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182752 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028370 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[breathnach-5] Breathnach FM, Malone FD (2007). "Screening for aneuploidy in first and second trimesters: is there an optimal paradigm?". Curr. Opin. Obstet. Gynecol. 19 (2): 176–82. doi:10.1097/GCO.0b013e3280895e00. PMID 17353686.

[entrez-6] "Entrez Gene: PAPPA pregnancy-associated plasma protein A, pappalysin 1".

[pmid10913121-7] Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C (October 2000). "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor". J. Biol. Chem. 275 (40): 31128–33. doi:10.1074/jbc.M001384200. PMID 10913121.

[pmid12421832-8] Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C (January 2003). "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment". J. Biol. Chem. 278 (4): 2106–17. doi:10.1074/jbc.M208777200. PMID 12421832.

[pmid7685339-9] Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L (June 1993). "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein". J. Biol. Chem. 268 (17): 12243–6. PMID 7685339.

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

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案内

案内

PAPP-A