- 関
- IGF-2 receptor、IGF-II receptor、insulin-like growth factor II receptor、mannose 6-phosphate receptor
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- the 9th letter of the Roman alphabet (同)i
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- 『私は』私が
- iodineの化学記号
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/18 13:19:22」(JST)
[Wiki en表示]
| Insulin-like growth factor 2 receptor |
PDB rendering based on 1e6f. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2L29, 2L2A, 2V5N, 2V5O, 2V5P
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| Identifiers |
| Symbols |
IGF2R ; CD222; CIMPR; M6P-R; MPR1; MPRI |
| External IDs |
OMIM: 147280 MGI: 96435 HomoloGene: 676 ChEMBL: 3240 GeneCards: IGF2R Gene |
| Gene ontology |
| Molecular function |
• glycoprotein binding
• G-protein alpha-subunit binding
• retinoic acid binding
• receptor activity
• G-protein coupled receptor activity
• insulin-like growth factor-activated receptor activity
• transporter activity
• protein binding
• mannose binding
• enzyme binding
• insulin-like growth factor II binding
• identical protein binding
• phosphoprotein binding
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| Cellular component |
• extracellular space
• nuclear envelope lumen
• lysosomal membrane
• endosome
• late endosome
• integral component of plasma membrane
• cell surface
• membrane
• clathrin coat
• endocytic vesicle
• trans-Golgi network transport vesicle
• perinuclear region of cytoplasm
• extracellular vesicular exosome
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| Biological process |
• liver development
• receptor-mediated endocytosis
• signal transduction
• G-protein coupled receptor signaling pathway
• spermatogenesis
• post-embryonic development
• organ regeneration
• response to retinoic acid
• positive regulation of apoptotic process
• insulin-like growth factor receptor signaling pathway
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| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
3482 |
16004 |
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| Ensembl |
ENSG00000197081 |
ENSMUSG00000023830 |
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| UniProt |
P11717 |
Q07113 |
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| RefSeq (mRNA) |
NM_000876 |
NM_010515 |
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| RefSeq (protein) |
NP_000867 |
NP_034645 |
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| Location (UCSC) |
Chr 6:
160.39 – 160.53 Mb |
Chr 17:
12.68 – 12.77 Mb |
|
| PubMed search |
[1] |
[2] |
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This article is about the cation-independent mannose 6-phosphate receptor. For the cation-dependent receptor, see cation-dependent mannose-6-phosphate receptor.
Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene.[1][2] IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6-phosphate (M6P)-tagged proteins in the trans-Golgi network.[2]
Contents
- 1 Structure
- 2 Function
- 3 Interactions
- 4 Evolution
- 5 See also
- 6 References
- 7 Further reading
- 8 External links
Structure
The structure of the IGF2R is a type I transmembrane protein (that is, it has a single transmembrane domain with its C-terminus on the cytoplasmic side of lipid membranes) with a large extracellular/lumenal domain and a relatively short cytoplasmic tail.[3] The extracellular domain consists of a small region homologous to the collagen-binding domain of fibronectin and of fifteen repeats of approximately 147 amino acid residues. Each of these repeats is homologous to the 157-residue extracytoplasmic domain of the mannose 6-phosphate receptor. Binding to IGF2 is mediated through one of the repeats, while two different repeats are responsible for binding to mannose-6-phosphate. The IGF2R is approximately 300 kDa in size; it appears to exist and function as a dimer.
Function
IGF2R functions to clear IGF2 from the cell surface to attenuate signalling, and to transport lysosomal acid hydrolase precursors from the Golgi apparatus to the lysosome. After binding IGF2 at the cell surface, IGF2Rs accumulate in forming clathrin-coated vesicles and are internalized. In the lumen of the trans-Golgi network, the IGF2R binds M6P-tagged cargo.[3] The IGF2Rs (bound to their cargo) are recognized by the GGA family of clathrin adaptor proteins and accumulate in forming clathrin-coated vesicles.[4] IGF2Rs from both the cell surface and the Golgi are trafficked to the early endosome where, in the relatively low pH environment of the endosome, the IGF2Rs release their cargo. The IGF2Rs are recycled back to the Golgi by the retromer complex, again by way of interaction with GGAs and vesicles. The cargo proteins are then trafficked to the lysosome via the late endosome independently of the IGF2Rs.
Interactions
Insulin-like growth factor 2 receptor has been shown to interact with M6PRBP1.[5][6]
Evolution
The insulin-like growth factor 2 receptor function evolved from the cation-independent mannose 6-phosphate receptor and is first seen in Monotremes. The IGF-2 binding site was likely acquired fortuitously with the generation of an exonic splice site enhancer cluster in exon 34, presumably necessitated by several kilobases of repeat element insertions in the preceding intron. A six-fold affinity maturation then followed during therian evolution, coincident with the onset of imprinting and consistent with the theory of parental conflict. [7]
See also
- Cluster of differentiation
- IGF-1 Receptor
- Mannose 6-phosphate receptor
References
- ^ Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (February 1988). "The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells". J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.
- ^ a b Laureys G, Barton DE, Ullrich A, Francke U (October 1988). "Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse". Genomics 3 (3): 224–9. doi:10.1016/0888-7543(88)90083-3. PMID 2852162.
- ^ a b Ghosh P, Dahms NM, Kornfeld S (March 2003). "Mannose 6-phosphate receptors: new twists in the tale". Nat. Rev. Mol. Cell Biol. 4 (3): 202–12. doi:10.1038/nrm1050. PMID 12612639.
- ^ Ghosh P, Kornfeld S (July 2004). "The GGA proteins: key players in protein sorting at the trans-Golgi network". Eur. J. Cell Biol. 83 (6): 257–62. doi:10.1078/0171-9335-00374. PMID 15511083.
- ^ Díaz E, Pfeffer SR (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. PMID 9590177.
- ^ Orsel JG, Sincock PM, Krise JP, Pfeffer SR (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. doi:10.1073/pnas.160251397. PMC 16819. PMID 10908666.
- ^ Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB (November 2012). "Exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution". Science 338 (6111): 1209–1213. doi:10.1126/science.1228633. PMID 23197533.
Further reading
- O'Dell SD, Day IN (1998). "Insulin-like growth factor II (IGF-II)". Int. J. Biochem. Cell Biol. 30 (7): 767–71. doi:10.1016/S1357-2725(98)00048-X. PMID 9722981.
- Hawkes C, Kar S (2004). "The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system". Brain Res. Brain Res. Rev. 44 (2–3): 117–40. doi:10.1016/j.brainresrev.2003.11.002. PMID 15003389.
- Scott CD, Firth SM (2005). "The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?". Horm. Metab. Res. 36 (5): 261–71. doi:10.1055/s-2004-814477. PMID 15156403.
- Antoniades HN, Galanopoulos T, Neville-Golden J, Maxwell M (1992). "Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry". Int. J. Cancer 50 (2): 215–22. doi:10.1002/ijc.2910500210. PMID 1370435.
- Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology 131 (3): 1230–40. doi:10.1210/en.131.3.1230. PMID 1380437.
- Morgan DO, Edman JC, Standring DN, Fried VA, Smith MC, Roth RA, Rutter WJ (1987). "Insulin-like growth factor II receptor as a multifunctional binding protein". Nature 329 (6137): 301–7. doi:10.1038/329301a0. PMID 2957598.
- Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (1988). "The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells". J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.
- De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL (1996). "M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity". Nat. Genet. 11 (4): 447–9. doi:10.1038/ng1295-447. PMID 7493029.
- Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544.
- De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL (1995). "Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors". Oncogene 10 (9): 1725–9. PMID 7753549.
- Schmidt B, Kiecke-Siemsen C, Waheed A, Braulke T, von Figura K (1995). "Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor". J. Biol. Chem. 270 (25): 14975–82. doi:10.1074/jbc.270.25.14975. PMID 7797478.
- Rao PH, Murty VV, Gaidano G, Hauptschein R, Dalla-Favera R, Chaganti RS (1994). "Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 66 (4): 272–3. doi:10.1159/000133710. PMID 8162705.
- Ishiwata T, Bergmann U, Kornmann M, Lopez M, Beger HG, Korc M (1997). "Altered expression of insulin-like growth factor II receptor in human pancreatic cancer". Pancreas 15 (4): 367–73. doi:10.1097/00006676-199711000-00006. PMID 9361090.
- Tikkanen R, Peltola M, Oinonen C, Rouvinen J, Peltonen L (1998). "Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase". EMBO J. 16 (22): 6684–93. doi:10.1093/emboj/16.22.6684. PMC 1170273. PMID 9362483.
- Nykjaer A, Christensen EI, Vorum H, Hager H, Petersen CM, Røigaard H, Min HY, Vilhardt F, Møller LB, Kornfeld S, Gliemann J (1998). "Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction". J. Cell Biol. 141 (3): 815–28. doi:10.1083/jcb.141.3.815. PMC 2132758. PMID 9566979.
- Díaz E, Pfeffer SR (1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. PMID 9590177.
- Wan L, Molloy SS, Thomas L, Liu G, Xiang Y, Rybak SL, Thomas G (1998). "PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization". Cell 94 (2): 205–16. doi:10.1016/S0092-8674(00)81420-8. PMID 9695949.
- Killian JK, Jirtle RL (1999). "Genomic structure of the human M6P/IGF2 receptor". Mamm. Genome 10 (1): 74–7. doi:10.1007/s003359900947. PMID 9892739.
- Kumar S, Hand AT, Connor JR, Dodds RA, Ryan PJ, Trill JJ, Fisher SM, Nuttall ME, Lipshutz DB, Zou C, Hwang SM, Votta BJ, James IE, Rieman DJ, Gowen M, Lee JC (1999). "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions". J. Biol. Chem. 274 (24): 17123–31. doi:10.1074/jbc.274.24.17123. PMID 10358067.
External links
- Insulin-Like-Growth-Factor II Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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PDB gallery
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1e6f: HUMAN MIR-RECEPTOR, REPEAT 11
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1gp0: HUMAN IGF2R DOMAIN 11
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1gp3: HUMAN IGF2R DOMAIN 11
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1gqb: HUMAN MIR-RECEPTOR, REPEAT 11
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2cnj: NMR STUDIES ON THE INTERACTION OF INSULIN-GROWTH FACTOR II (IGF-II) WITH IGF2R DOMAIN 11
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Receptors: growth factor receptors
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| Type I cytokine receptor |
- Nerve growth factors: Ciliary neurotrophic factor
- Erythropoietin
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| Receptor protein serine/threonine kinase |
- TGF pathway: TGF-beta
- Activin
- Bone morphogenetic protein
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| Receptor tyrosine kinase |
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- Nerve growth factors: high affinity Trk
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- Somatomedin
- Insulin-like growth factor 1
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- ErbB/Epidermal growth factor
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| Tumor necrosis factor receptor |
- Nerve growth factors: Low affinity/p75
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| Ig superfamily |
- Platelet-derived growth factor
- Stem cell factor
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| Other/ungrouped |
- Somatomedin
- Insulin-like growth factor 2
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Index of signal transduction
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| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene.
- Shi Q1, Haenen GR1, Maas L1, Arlt VM2,3, Spina D4, Vasquez YR4, Moonen E1, Veith C1, Van Schooten FJ1, Godschalk RW5.
- Archives of toxicology.Arch Toxicol.2016 Sep;90(9):2261-73. doi: 10.1007/s00204-015-1593-7. Epub 2015 Oct 5.
- PMID 26438400
- Toll-like Receptor 2 Signalling and the Lysosomal Machinery in Barrett's Esophagus.
- Verbeek RE1, Siersema PD2, Vleggaar FP3, Ten Kate FJ4, Posthuma G5, Souza RF6, de Haan J3, van Baal JW3.
- Journal of gastrointestinal and liver diseases : JGLD.J Gastrointestin Liver Dis.2016 Sep;25(3):273-82. doi: 10.15403/jgld.2014.1121.253.rc2.
- PMID 27689189
- Mode localization in the cooperative dynamics of protein recognition.
- Copperman J1, Guenza MG2.
- The Journal of chemical physics.J Chem Phys.2016 Jul 7;145(1):015101. doi: 10.1063/1.4954506.
- PMID 27394125
Japanese Journal
- A case of type A insulin resistance associated with heterozygous Asn462Ser mutation of the insulin receptor gene
- Hashimoto Naoko,Yokoi Norihide,Komada Hisako [他]
- Diabetology international 3(4), 239-243, 2012-00-00
- NAID 40019530692
- インスリン受容体異常症A型に対する19年間のIGF-1治療
- 原田 真耶,内潟 安子,片岡 菜奈子 [他],三浦 順之助,望月 弘,柳沢 慶香,佐倉 宏,岩本 安彦
- 糖尿病 53(8), 626-630, 2010-08-30
- NAID 10026713561
- Effects of Topical Application of α-D-Glucosylglycerol on Dermal Levels of Insulin-Like Growth Factor-I in Mice and on Facial Skin Elasticity in Humans
- Harada Naoaki,Zhao Juan,Kurihara Hiroki [他],NAKAGATA Naomi,OKAJIMA Kenji
- Bioscience, biotechnology, and biochemistry 74(4), 759-765, 2010-04-23
- … We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans. … In this study, we examined whether topical application of α-D-glucosylglycerol (GG), a compound found in Japanese traditional brewed foods such as sake (Japanese rice wine), increases the dermal production of IGF-I in mice and increases the facial skin elasticity in females. …
- NAID 10027553739
Related Links
- "Receptor, IGF Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are ... A receptor that is specific for IGF-II and mannose-6-phosphate. The ...
- IGF Type 2 Receptor (n.) 1. (MeSH) A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE ...
★リンクテーブル★
[★]
- マンノース6リン酸受容体、マンノース6リン酸レセプター
- 関
- IGF type 2 receptor、IGF-2 receptor、IGF-II receptor、insulin-like growth factor II receptor、MPR
[★]
- 関
- IGF type 2 receptor、IGF-2 receptor、IGF-II receptor、mannose 6-phosphate receptor
[★]
- 関
- IGF type 2 receptor、IGF-2 receptor、insulin-like growth factor II receptor、mannose 6-phosphate receptor
[★]
- 関
- IGF type 2 receptor、IGF-II receptor、insulin-like growth factor II receptor、mannose 6-phosphate receptor
[★]
- 英
- IGF type 2 receptor
- 関
- マンノース6リン酸受容体、IGF-2受容体、IGF-II受容体、インスリン様増殖因子II受容体
[★]
- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
[★]
[★]
[★]
- 関
- form、mode、pattern、type
[★]