WordNet

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 鎌状ヘモグロビン多量体：構造と機能特性 sickle hemoglobin polymer structure and functional properties
2. ビタミンＫとγカルボキシグルタミン酸の合成および機能 vitamin k and the synthesis and function of gamma carboxyglutamic acid
3. 自己免疫性肝炎の病因 pathogenesis of autoimmune hepatitis
4. 成人におけるS状結腸鏡検査および大腸内視鏡検査のための前処置 bowel preparation for colonoscopy and flexible sigmoidoscopy in adults
5. 直腸腟瘻、肛門腟瘻、および結腸膀胱瘻 rectovaginal anovaginal and colovesical fistulas

Characterization of Self-Assembled Monolayers of Peptide Mimotopes of CD20 Antigen and Their Binding with Rituximab.

Leo N1, Shang Y1, Yu JJ2,3, Zeng X1.
Langmuir : the ACS journal of surfaces and colloids.Langmuir.2015 Dec 29;31(51):13764-72. doi: 10.1021/acs.langmuir.5b02605. Epub 2015 Dec 14.
CD20, expressed in greater than 90% of B-lymphocytic lymphomas, is a target for antibody therapy. Rituximab is a chimeric therapeutic monoclonal antibody (mAb) against the protein CD20, allowing it to destroy B cells and to treat lymphoma, leukemia, transplant rejection, and autoimmune disorder. In
PMID 26609837

Significance of Ser-188 in human mitochondrial NAD kinase as determined by phosphomimetic and phosphoresistant amino-acid substitutions.

Kawabata Y1, Murata K2, Kawai S3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Dec 25;468(4):691-5. doi: 10.1016/j.bbrc.2015.11.017. Epub 2015 Nov 12.
Human mitochondrial NAD kinase is a crucial enzyme responsible for the synthesis of mitochondrial NADP(+). Despite its significance, little is known about the regulation of this enzyme in the mitochondria. Several putative and known phosphorylation sites within the protein have been found using phos
PMID 26577408

Regulation of Acetate Metabolism and Acetyl Co-A Synthetase 1 (ACS1) Expression by Methanol Expression Regulator 1 (Mxr1p) in the Methylotrophic Yeast, Pichia pastoris.

Sahu U1, Rangarajan PN2.
The Journal of biological chemistry.J Biol Chem.2015 Dec 9. pii: jbc.M115.673640. [Epub ahead of print]
Methanol expression regulator 1 (Mxr1p) is a zinc finger protein that regulates the expression of genes encoding enzymes of methanol utilization (mut) pathway in the methylotrophic yeast, Pichia pastoris by binding to Mxr1p response elements (MXREs) present in their promoters. Here, we demonstrate t
PMID 26663080

赤井翔太,生城浩子,澤井大樹,林秀行,神谷信夫,宮原郁子
ビタミン 88(7), 358-365, 2014-07-25
… In the homoserine-binding forms, the amino group of homoserine made a hydrogen bond to the side chain carboxylate of Glu180. … The substrate homoserine was rigidly recognized by several amino acid residues in the enzyme active site, indicating that Lys99 or Lys195 would be an essential catalytic residue to facilitate hydride transfer. …
NAID 110009833078

Involvement of Val 315 located in the C-terminal region of thermolysin in its expression in Escherichia coli and its thermal stability.

Kojima Kenji,Nakata Hiroki,Inouye Kuniyo
Biochimica et biophysica acta -Proteins and Proteomics 1844(2), 330-338, 2014-02
… The C-terminal Lys316 residue was not significant in the expression, but Val315 was critical. … Variants with charged (Asp, Glu, Lys, and Arg), bulky (Trp), or small (Gly) amino acids were lower in these characteristics than WT. …
NAID 120005359199

Effect of Cytochrome P450 2C19 and 2C9 Amino Acid Residues 72 and 241 on Metabolism of Tricyclic Antidepressant Drugs

Attia Tamer Zekry,Yamashita Taku,Hammad Mohamed Abdelkhalek,Hayasaki Akinori,Sato Takumi,Miyamoto Masayoshi,Yasuhara Yuki,Nakamura Takashi,Kagawa Yusuke,Tsujino Hirofumi,Omar Mahmoud Ahmed,Abdelmageed Osama Hassan,Derayea Sayed Mohamed,Uno Tadayuki
Chemical and Pharmaceutical Bulletin 62(2), 176-181, 2014
… the former has lysines in both positions (Lys72 and Lys241), and the latter has glutamic acids (Glu72 and Glu241). … We could also show linear correlations between metabolic activities and binding affinities, and hence we conclude that amino acid residue 72 plays a key role in TCA drug metabolism by limiting the binding affinities of CYP2C19 and CYP2C9. …
NAID 130003390760