WordNet

place signs, as along a road; "sign an intersection"; "This road has been signed"
(medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
a character indicating a relation between quantities; "dont forget the minus sign"
a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
a gesture that is part of a sign language
a public display of a message; "he posted signs in all the shop windows"
engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
an Iranian language spoken in Afghanistan (同)Dari Persian
having a handwritten signature; "a signed letter"

PrepTutorEJDIC

(ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
=ti

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/07 16:22:47」(JST)

wiki en

stroking of skin leads to localised subcutaneous anaphylactoid reaction leading to mast cell degranulation and urticarial rash.

Darier's sign is a change observed after stroking the skin of a person with systemic mastocytosis or urticaria pigmentosa.

In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the skin.

Eponym

Darier's sign is named after the French dermatologist Ferdinand-Jean Darier who first described it.^[1]

References

^ synd/489 at Who Named It?

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UpToDate Contents

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1. 肥満細胞症（皮膚および全身性）：疫学、病因、および臨床症状 mastocytosis cutaneous and systemic epidemiology pathogenesis and clinical manifestations
2. 肥満細胞症（皮膚および全身性）の評価および診断 evaluation and diagnosis of mastocytosis cutaneous and systemic
3. 若年性黄色肉芽腫（JXG） juvenile xanthogranuloma jxg
4. UVA1療法 uva1 phototherapy
5. 先天性色素性母斑 congenital melanocytic nevi

English Journal

Diffuse cutaneous bullous mastocytosis with IgM deposits at dermo-epidermal junction.

Slavescu KC1, Chiorean R2, Danescu S2, Bota M1, Rogojan L3, Baican A2.
Journal of cutaneous pathology.J Cutan Pathol.2016 Mar;43(3):263-9. doi: 10.1111/cup.12635. Epub 2015 Oct 29.
Cutaneous mastocytosis is a disease characterized by the infiltration and proliferation of mast cells in the skin. In children, the most common form of presentation is urticaria pigmentosa, while the diffuse cutaneous bullous mastocytosis is one of the rarest subtypes seen. The aim of this paper is
PMID 26435030

Pseudo Darier Sign: A Distinctive Finding for Congenital Smooth Muscle Hamartoma.

Bilgiç Ö1, Tunçez Akyürek F1, Altınyazar HC1.
The Journal of pediatrics.J Pediatr.2016 Feb;169:318. doi: 10.1016/j.jpeds.2015.10.084. Epub 2015 Nov 25.
PMID 26621046