| Madagascar rosy periwinkle |
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| Scientific classification |
| Kingdom: |
Plantae |
| Clade: |
Angiosperms |
| Clade: |
Eudicots |
| Clade: |
Asterids |
| Order: |
Gentianales |
| Family: |
Apocynaceae |
| Genus: |
Catharanthus |
| Species: |
C. roseus |
| Binomial name |
Catharanthus roseus
(L.) G.Don, 1837 |
| Synonyms |
- Vinca rosea (basionym)
- Ammocallis rosea
- Lochnera rosea
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Wikimedia Commons has media related to Catharanthus roseus. |
A Catharanthus Roseus flower in Hyderabad, Pakistan
Catharanthus roseus, commonly known as the Madagascar periwinkle, rose periwinkle, or rosy periwinkle, is a species of flowering plant in the dogbane family Apocynaceae. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. Other English names include Vinca, Cape periwinkle, rose periwinkle, rosy periwinkle, and "old-maid".[1][2] It was formerly included in the genus Vinca as Vinca rosea.
Contents
- 1 Synonyms
- 2 Description
- 3 Cultivation and uses
- 4 Chemical constituents
- 5 Other names
- 6 Gallery
- 7 References
- 8 External links
Synonyms
Two varieties are recognized
- Catharanthus roseus var. roseus
- Synonymy for this variety
- Catharanthus roseus var. angustus Steenis ex Bakhuizen f.[3]
- Catharanthus roseus var. albus G.Don[4]
- Catharanthus roseus var. occellatus G.Don[4]
- Catharanthus roseus var. nanus Markgr.[5]
- Lochnera rosea f. alba (G.Don) Woodson[6]
- Lochnera rosea var. ocellata (G.Don) Woodson
- Catharanthus roseus var. angustus (Steenis) Bakh. f.[7]
- Synonymy for this variety
- Catharanthus roseus var. nanus Markgr.[8]
- Lochnera rosea var. angusta Steenis[9]
Description
It is an evergreen subshrub or herbaceous plant growing 1 m tall. The leaves are oval to oblong, 2.5–9 cm long and 1–3.5 cm broad, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm long; they are arranged in opposite pairs. The flowers are white to dark pink with a darker red centre, with a basal tube 2.5–3 cm long and a corolla 2–5 cm diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm long and 3 mm broad.[10][11][12][13]
In the wild, it is an endangered plant; the main cause of decline is habitat destruction by slash and burn agriculture.[14] It is also however widely cultivated and is naturalised in subtropical and tropical areas of the world.[10] It is so well adapted to growth in Australia, that it is listed as a noxious weed in Western Australia and the Australian Capital Territory,[15] and also in parts of eastern Queensland.[16]
Pale Pink with Red Centre Cultivar
Cultivation and uses
The species has long been cultivated for herbal medicine and as an ornamental plant. In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, though poisonous, are used against several diseases. In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma.[11] Many of the vinca alkaloids were first isolated from Catharanthus roseus,[17] including vinblastine and vincristine used in the treatment of leukemia[14] and Hodgkin's lymphoma.[11]
A Periwinkle shrub in Hyderabad, Pakistan
This conflict between historical indigenous use, and recent patents on C.roseus-derived drugs by western pharmaceutical companies, without compensation, has led to accusations of biopiracy.[18]
C. roseus can be extremely toxic if consumed orally by humans, and is cited (under its synonym Vinca rosea) in the Louisiana State Act 159.
As an ornamental plant, it is appreciated for its hardiness in dry and nutritionally deficient conditions, popular in subtropical gardens where temperatures never fall below 5 °C to 7 °C, and as a warm-season bedding plant in temperate gardens. It is noted for its long flowering period, throughout the year in tropical conditions, and from spring to late autumn, in warm temperate climates. Full sun and well-drained soil are preferred. Numerous cultivars have been selected, for variation in flower colour (white, mauve, peach, scarlet and reddish-orange), and also for tolerance of cooler growing conditions in temperate regions. Notable cultivars include 'Albus' (white flowers), 'Grape Cooler' (rose-pink; cool-tolerant), the Ocellatus Group (various colours), and 'Peppermint Cooler' (white with a red centre; cool-tolerant).[10]
C. roseus is used in plant pathology as an experimental host for phytoplasmas.[19] This is because it is easy to infect with a large majority of phytoplasmas, and also often has very distinctive symptoms such as phyllody and significantly reduced leaf size.[20]
Chemical constituents
Vinblastine and vincristine, chemotherapy medications used to treat several types of cancers, are found in the plant[21][22][23][24] and are biosynthesised from the coupling of the alkaloids catharanthine and vindoline.[25] The newer semi-synthetic chemotherapeutic agent vinorelbine, used in the treatment of non-small-cell lung cancer,[23][26] can be prepared either from vindoline and catharanthine[23][27] or from the vinca alkaloid leurosine,[28] in both cases via anhydrovinblastine.[27]
Rosinidin is an anthocyanidin pigment found in the flowers of C. roseus.[29]
Other names
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This section does not cite any sources. Please help improve this section by adding citations to reliable sources. Unsourced material may be challenged and removed. (June 2016) (Learn how and when to remove this template message)
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C. roseus is known as boa-noite ("good night") and maria-sem-vergonha ("shameless maria", name shared with Impatiens and Thunbergia alata) in Portuguese (American), vinca-de-madagáscar, vinca-de-gato ("cats' vinca"), vinca-branca (white vinca), vinca or boa-noite in Portuguese (European), vinca del Cabo, vinca rosa ("pink vinca") or vinca rosada ("roseous vinca") in Spanish, putica ("little whore") in Venezuela, teresita in the southern part of Mexico, specifically in Champotón, Campeche and Mérida,[30] "İzmir Güzeli" in Turkish (meaning Smyrna beauty) indicating the city that has the best climate conditions for it to flourish in Turkey, and "Dhafnaki" [in Greek Language Δαφνάκι] (meaning little Daphne) in Greece and Cyprus. It is also called Nithya Kalyani (நித்ய கல்யாணி) and Sudukaatu Mallikai in Tamil Nadu. It is called Nayantara (নযনতারা) ("eyeball") in Bengali.
Gallery
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Catharanthus roseus in Kerala
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Vinca From a garden at Cox's Bazar Bangladesh
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Flower bud in West Bengal, India.
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Garden Plant in India & Pakistan
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Common garden plant in India & Pakistan
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Catharanthus roseus in Pakistan
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Flower plant raised in India Temples
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Pacifica Burgundy Halo – Madagascar Periwinkle
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Red cultivar of Madagascar Periwinkle
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Potted Plant in New Delhi
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References
- ^ Flora of Madagascar: Catharanthus roseus
- ^ "Catharanthus roseus". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 12 December 2017.
- ^ Steenis ex Bakhuizen f., Blumea 6: 384. 1950.
- ^ a b G.Don, Gen. Hist. 4(1): 95. 1837.
- ^ Markgr., Adansonia, ser. 2. 12: 222. 1972.
- ^ Woodson, N. Amer. Fl. 29: 124. 1938.
- ^ Bakh. f.Blumea 6 (2): 384. 1950.
- ^ Markgr. Adansonia, ser. 2. 12: 222. 1972.
- ^ Steenis Trop. Nat. 25: 18. 1936.
- ^ a b c Huxley, A., ed. (1992). New RHS Dictionary of Gardening. Macmillan ISBN 0-333-47494-5.
- ^ a b c Flora of China: Catharanthus roseus
- ^ College of Micronesia: Catharanthus roseus
- ^ Jepson Flora: Catharanthus roseus
- ^ a b DrugDigest: Catharanthus roseus Archived 2007-09-27 at the Wayback Machine.
- ^ "Catharanthus roseus". Orpheus Island Research Station – James Cook University. Retrieved 2 November 2015.
- ^ "Factsheet – Catharanthus roseus". Queensland Government. Retrieved 2 November 2015.
- ^ van Der Heijden, Robert; Jacobs, Denise I.; Snoeijer, Wim; Hallard, Didier; Verpoorte, Robert (2004). "The Catharanthus alkaloids: Pharmacognosy and biotechnology". Current Medicinal Chemistry. 11 (5): 607–628. doi:10.2174/0929867043455846. PMID 15032608.
- ^ Karasov, Corliss (2001). "Who Reaps the Benefits of Biodiversity?" (PDF). Environmental Health Perspectives. 109 (12): A582–A587. PMC 1240518 . PMID 11748021.
- ^ Marcone, C.; Ragozzino, A.; Seemuller, E. (1997). "Dodder transmission of alder yellows phytoplasma to the experimental host Catharanthus roseus (periwinkle)". Forest Pathology. 27 (6): 347–350. doi:10.1111/j.1439-0329.1997.tb01449.x.
- ^ Chang, Chung-Jan (1998). "Pathogenicity of Aster Yellows Phytoplasma and Spiroplasma citri on Periwinkle". Phytopathology. 88 (12): 1347–1350. doi:10.1094/PHYTO.1998.88.12.1347 .
- ^ Gansäuer, Andreas; Justicia, José; Fan, Chun-An; Worgull, Dennis; Piestert, Frederik (2007). "Reductive C—C bond formation after epoxide opening via electron transfer". In Krische, Michael J. Metal Catalyzed Reductive C—C Bond Formation: A Departure from Preformed Organometallic Reagents. Topics in Current Chemistry. 279. Springer Science & Business Media. pp. 25–52. doi:10.1007/128_2007_130. ISBN 978-3-540-72879-5.
- ^ Cooper, Raymond; Deakin, Jeffrey John (2016). "Africa's gift to the world". Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press. pp. 46–51. ISBN 978-1-4987-0430-4.
- ^ a b c Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17: 5893–5914. doi:10.3390/molecules17055893. PMID 22609781.
- ^ Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John Wiley & Sons. pp. 157–159. ISBN 978-3-527-32669-3.
- ^ Hirata, K.; Miyamoto, K.; Miura, Y. (1994). "Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures". In Bajaj, Y. P. S. Biotechnology in Agriculture and Forestry 26. Medicinal and Aromatic Plants. VI. Springer-Verlag. pp. 46–55. ISBN 978-3-540-56391-4.
- ^ Faller, Bryan A.; Pandi, Trailokya N. (2011). "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: 131–144. doi:10.4137/CMO.S5074. PMC 3117629 .
- ^ a b Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guénard, Daniel; Guéritte, Françoise (2009). "Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids". Journal of Medicinal Chemistry. 52 (1): 134–142. doi:10.1021/jm801064y. PMID 19072542.
- ^ Hardouin, Christophe; Doris, Eric; Rousseau, Bernard; Mioskowski, Charles (2002). "Concise synthesis of anhydrovinblastine from leurosine". Organic Letters. 4 (7): 1151–1153. doi:10.1021/ol025560c.
- ^ Toki, Kenjiro; Saito, Norio; Irie, Yuki; Tatsuzawa, Fumi; Shigihara, Atsushi; Honda, Toshio (2008). "7-O-Methylated anthocyanidin glycosides from Catharanthus roseus". Phytochemistry. 69 (5): 1215–1219. doi:10.1016/j.phytochem.2007.11.005. PMID 18164044.
- ^ Translated by Livio III Ceballos García, all credits goes to the quoted website http://ornamentalis.com/catharanthus-roseus/
External links
Taxon identifiers
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- Wd: Q161093
- APDB: 71614
- ARKive: catharanthus-roseus
- EoL: 581125
- FloraBase: 6569
- FoC: 200018366
- GBIF: 3169830
- GRIN: 70159
- iNaturalist: 62924
- IPNI: 77880-1
- ITIS: 30168
- NCBI: 4058
- PalDat: Catharanthus_roseus
- Plant List: kew-35719
- PLANTS: CARO14
- Tropicos: 1800007
- WCSP: 35719
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