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1. ヘム色素誘発性急性腎障害の臨床的特徴および診断clinical features and diagnosis of heme pigment induced acute kidney injury [show details]
…The predominant form of CK released from damaged striated muscles is the MM isoform, although a small quantity of the MB isoform may also be released. As a result, mildly elevated CK MB levels may be seen…
2. 神経筋疾患の評価における筋酵素muscle enzymes in the evaluation of neuromuscular diseases [show details]
…paralleling the elevation of CK-MB . Brain tissue CK consists of 90 percent CK-BB with the remainder CK-MM. Smaller amounts of CK are also found in the intestine, lung, and bladder . Macro CK is a term used…
3. 拡張型心筋症の遺伝学genetics of dilated cardiomyopathy [show details]
… (7.7 percent) associated with subclinical skeletal muscle disease with variable levels of serum CK-MM and with dystrophic changes on skeletal muscle biopsy.… mutations and one of 192 with an ILK gene mutation . VCL – A gene that codes for vinculin (VCL) and its isoform, metavinculin, has been identified on chromosome 10q22.1-q23 . Vinculin and metavinculin are protein …
4. 腎不全患者における血清心臓バイオマーカーserum cardiac biomarkers in patients with renal failure [show details]
5. 横紋筋融解症の臨床症状および診断clinical manifestations and diagnosis of rhabdomyolysis [show details]
…myocardial infarction. Additionally, the CK-MM fraction is elevated, while little or no CK-MB is present. Assays for cardiac troponins (both the I and T isoforms) are highly sensitive and specific for cardiac …

English Journal

CA19-9 and apolipoprotein-A2 isoforms as detection markers for pancreatic cancer: a prospective evaluation.

Honda K, Katzke VA, Hüsing A, Okaya S, Shoji H, Onidani K, Olsen A, Tjønneland A, Overvad K, Weiderpass E, Vineis P, Muller D, Tsilidis K, Palli D, Pala V, Tumino R, Naccarati A, Panico S, Aleksandrova K, Boeing H, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Lagiou P, Khaw KT, Wareham N, Travis RC, Merino S, Duell EJ, Rodríguez-Barranco M, Chirlaque MD, Barricarte A, Rebours V, Boutron-Ruault MC, Romana Mancini F, Brennan P, Scelo G, Manjer J, Sund M, Öhlund D, Canzian F, Kaaks R.
International journal of cancer. 2019 Apr;144(8)1877-1887.
Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform ("ApoA2-ATQ/AT"), alone and in combination with carbohydrate antigen 19-9 (CA19-9), as an early detection biomarke
PMID 30259989

Fibre-type-specific and Mitochondrial Biomarkers of Muscle Damage after Mountain Races.

Carmona G, Roca E, Guerrero M, Cussó R, Bàrcena C, Mateu M, Cadefau JA.
International journal of sports medicine. 2019 Apr;40(4)253-262.
Consequences of running mountain races on muscle damage were investigated by analysing serum muscle enzymes and fibre-type-specific sarcomere proteins. We studied 10 trained amateur and 6 highly trained runners who ran a 35 km and 55 km mountain trail race (MTR), respectively. Levels of creatine
PMID 30836391

A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury.

Bailey WJ, Barnum JE, Erdos Z, LaFranco-Scheuch L, Lane P, Vlasakova K, Sistare FD, Glaab WE.
Toxicological sciences : an official journal of the Society of Toxicology. 2019 Mar;168(1)110-125.
Liver and skeletal muscle-specific microRNAs (miRNAs) are currently being evaluated as novel plasma biomarkers that may out-perform or add value to the conventional liver injury biomarkers alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and to the skeletal muscle injury biomarke
PMID 30496518

Japanese Journal

心筋梗塞とクレアチンキナーゼ

高木康
生物物理化学 = Journal of Electrophoresis 42(2), 109-112, 1998-06-15
NAID 10016368939

古くて新しいＺｙｍｏｇｒａｐｈｙ　その基礎と臨床　　心筋梗塞とクレアチンキナーゼ

高木康
生物物理化学 42(2), 109-112, 1998
… Creatine kinase (CK, EC 2.7.3.2) has a important role in muscle contraction and is rich in muscle tissue. … The CK has three isoenzymes, designated as CK-MM (also termed CK3), CK-MB (CK2) and CK-BB (CK1). …
NAID 130003607160

ＣＫ‐Ｍサブユニット変異（ｆａｓｔ　ｔｙｐｅ）の一家系

大井絹枝,為田靱彦,小坂義種
生物物理化学 37(4), 221-225, 1993
… 急性心筋梗塞を発症した82歳女性でCK-Mサブユニット変異 (fast type) を経験した. … fast type の変異Mサブユニットが存在する結果, CKアイソザイムのMMはブロードで, しかも通常のMMより陽極寄りに泳動された. …
NAID 130003606974