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1. 神経筋疾患の評価における筋酵素muscle enzymes in the evaluation of neuromuscular diseases [show details]
…paralleling the elevation of CK-MB . Brain tissue CK consists of 90 percent CK-BB with the remainder CK-MM. Smaller amounts of CK are also found in the intestine, lung, and bladder . Macro CK is a term used…
2. ヘム色素誘発性急性腎障害の臨床的特徴および診断clinical features and diagnosis of heme pigment induced acute kidney injury [show details]
…The predominant form of CK released from damaged striated muscles is the MM isoform, although a small quantity of the MB isoform may also be released. As a result, mildly elevated CK MB levels may be seen…
3. 拡張型心筋症の遺伝学genetics of dilated cardiomyopathy [show details]
… mutations and one of 192 with an ILK gene mutation . VCL – A gene that codes for vinculin (VCL) and its isoform, metavinculin, has been identified on chromosome 10q22.1-q23 . Vinculin and metavinculin are protein … (7.7 percent) associated with subclinical skeletal muscle disease with variable levels of serum CK-MM and with dystrophic changes on skeletal muscle biopsy.…
4. 腎不全患者における血清心臓バイオマーカーserum cardiac biomarkers in patients with renal failure [show details]
5. 横紋筋融解症の臨床症状および診断clinical manifestations and diagnosis of rhabdomyolysis [show details]
…myocardial infarction. Additionally, the CK-MM fraction is elevated, while little or no CK-MB is present. Assays for cardiac troponins (both the I and T isoforms) are highly sensitive and specific for cardiac …

English Journal

Explaining meat quality of bulls and steers by differential proteome and phosphoproteome analysis of skeletal muscle.

Silva LHP, Rodrigues RTS, Assis DEF, Benedeti PDB, Duarte MS, Chizzotti ML.
Journal of proteomics. 2019 May;199()51-66.
The objective of this study was to evaluate the differential proteome and phosphoproteome between bulls and steers during conversion of muscle to meat, as well as after 14 days of aging. Twelve male Nellore (Bos taurus indicus) calves were used, and six calves were randomly selected for surgical c
PMID 30862562

Intense resistance training induces pronounced metabolic stress and impairs hypertrophic response in hind-limb muscles of rats.

Guzzoni V, Briet L, Costa R, Souza RWA, Carani FR, Dal-Pai-Silva M, Silva KAS, Cunha TS, Marcondes FK.
Stress (Amsterdam, Netherlands). 2019 May;22(3)377-386.
Skeletal muscle hypertrophy is an exercise-induced adaptation, particularly in resistance training (RT) programs that use large volumes and low loads. However, evidence regarding the role of rest intervals on metabolic stress and muscular adaptations is inconclusive. Thus, we aimed to investigate th
PMID 30857457

Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1-deficiency increases amino acid use and impairs muscle function.

Zhao L, Pascual F, Bacudio L, Suchanek AL, Young PA, Li LO, Martin SA, Camporez JP, Perry RJ, Shulman GI, Klett EL, Coleman RA.
The Journal of biological chemistry. 2019 Apr;().
Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (Acsl1M-/-) severely reduces acyl-CoA synthetase activity and fatty acid oxidation. However, the effects of decreased fatty acid oxidation on skeletal muscle function, histology, use of alternative fuels, and mitochond
PMID 30975900