C型レクチン
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- any of several plant glycoproteins that act like specific antibodies but are not antibodies in that they are not evoked by an antigenic stimulus
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- carbonの化学記号
- cesiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/05 13:39:56」(JST)
[Wiki en表示]
| Lectin C-type domain |
|
Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin.[1]
|
| Identifiers |
| Symbol |
Lectin_C |
| Pfam |
PF00059 |
| InterPro |
IPR001304 |
| SMART |
CLECT |
| PROSITE |
PS50041 |
| SCOP |
2msb |
| SUPERFAMILY |
2msb |
| CDD |
cd00037 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.[2] The C-type designation is from their requirement for calcium for binding.[3] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[4][5]
Classification
Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.[6] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).[7] Most recently, three further subgroups were added (XV to XVII).[2]
| Group |
Name |
Associated domains |
| I |
Lecticans |
EGF, Sushi, Ig and Link domains |
| II |
Asialoglycoprotein and DC receptors |
None |
| III |
Collectins |
None |
| IV |
Selectins |
Sushi and EGF domains |
| V |
NK - cell receptors |
None |
| VI |
Multi-CTLD endocytic receptors |
FnII and Ricin domains |
| VII |
Reg group |
None |
| VIII |
Chondrolectin, Layilin |
None |
| IX |
Tetranectin |
None |
| X |
Polycystin |
WSC, REJ, PKD domains |
| XI |
Attractin (ATRN) |
PSI, EGF and CUB domains |
| XII |
Eosinophil major basic protein (EMBP) |
None |
| XIII |
DGCR2 |
None |
| XIV |
Thrombomodulin, CD93, CD248 |
EGF domains |
| XV |
Bimlec |
None |
| XVI |
SEEC |
SCP and EGF domains |
| XVII |
CBCP/Frem1/QBRICK |
CSPG repeats and CalX-beta domains |
CLECs include:
- CLEC1A, CLEC1B
- CLEC2A, CLEC2B, CD69 (CLEC2C), CLEC2D, CLEC2L
- CLEC3A, CLEC3B
- CLEC4A, CLEC4C, CLEC4D, CLEC4E, CLEC4F, CLEC4G, ASGR1 (CLEC4H1), ASGR2 (CLEC4H2), FCER2 (CLEC4J), CD207 (CLEC4K), CD209 (CLEC4L), CLEC4M
- CLEC5A
- CLEC6A
- CLEC7A
- OLR1 (CLEC8A)
- CLEC9A
- CLEC10A
- CLEC11A
- CLEC12A, CLEC12B
- CD302 (CLEC13A), LY75 (CLEC13B), PLA2R1 (CLEC13C), MRC1 (CLEC13D), MRC2 (CLEC13E)
- CLEC14A
- CLEC16A
- CLEC17A
The "NK Cell lectin-like receptors" are a very closely related group:[8]
- KLRA1
- KLRB1 (CLEC5B)
- KLRC1, KLRC2, KLRC3, KLRC4
- KLRD1
- KLRF1 (CLEC5C)
- KLRG1 (CLEC15A), KLRG2 (CLEC15B)
- KLRK1
Additional proteins containing this domain include:
- AGC1; ATRNL1
- BCAN
- CD248; CD72; CD93; CHODL; CL-K1-Ia; CL-K1-Ib; CL-K1-Ic; CLECSF5; COLEC10; COLEC11; COLEC12; CSPG3
- FCER2; FREM1; HBXBP;
- LAYN; LOC348174; LOC728276
- MAFA; MBL2; MGC34761; MICL; MRC1L1
- OLR1
- PAP; PKD1; PKD1L2; PLA2R1; PRG2; PRG3
- REG1A; REG1B; REG3A; REG3G; REG4
- SELE; SELL; SELP; SFTPA1; SFTPA2; SFTPA2B; SFTPD; SRCL
- THBD
- VCAN
References
- ^ Walker JR, Nagar B, Young NM, Hirama T, Rini JM (April 2004). "X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure". Biochemistry. 43 (13): 3783–92. doi:10.1021/bi035871a. PMID 15049685.
- ^ a b Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID 16336259.
- ^ C-Type Lectin at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
- ^ Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. doi:10.1016/j.cub.2009.03.032. PMID 19439262.
- ^ Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 45: 207–32. doi:10.1016/S0079-6603(08)60870-3. ISBN 978-0-12-540045-9. PMID 8341801.
- ^ Drickamer K, Fadden AJ (2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp. (69): 59–72. PMID 12655774.
- ^ NK Cell Lectin-Like Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
External links
- Functional Glycomics Gateway, a collaboration between the Consortium for Functional Glycomics and Nature Publishing Group
|
Protein: lectins
|
|
| Animal |
|
C-type lectins
|
- Asialoglycoprotein receptor
- KLRD1
- Collectin
- Mannose receptor
- proteochondroitin sulfate
- Aggrecan
- Versican
- Brevican
- Neurocan
|
|
|
Other
|
- Calnexin
- Calreticulin
- CD22
- CD33
- Galectin
- Myelin-associated glycoprotein
- N-Acetylglucosamine receptor
- Selectin
- Sialoadhesin
|
|
|
| Plant |
- Toxalbumins
- Mitogens
- Concanavalin A
- Phytohaemagglutinin
- Pokeweed mitogen
- Legume lectin
- BanLec
|
UpToDate Contents
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English Journal
- Collectin CL-P1 utilizes C-reactive protein for complement activation.
- Roy N1, Ohtani K1, Matsuda Y1, Mori K1, Hwang I1, Suzuki Y2, Inoue N3, Wakamiya N4.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Jun;1860(6):1118-28. doi: 10.1016/j.bbagen.2016.02.012. Epub 2016 Feb 23.
- BACKGROUND: C-reactive protein (CRP) is a plasma pentraxin family protein that is massively induced as part of the innate immune response to infection and tissue injury. CRP and other pentraxin proteins can activate a complement pathway through C1q, collectins, or on microbe surfaces. It has been fo
- PMID 26922829
- Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly.
- Wang Q1, Westra J2, van der Geest KS3, Moser J4, Bijzet J5, Kuiper T6, Lorencetti PG7, Joosten LA8, Netea MG9, Heeringa P10, Brouwer E11, Boots AM12.
- Experimental gerontology.Exp Gerontol.2016 Jun 1;78:39-46. doi: 10.1016/j.exger.2016.02.016. Epub 2016 Mar 2.
- OBJECTIVE: Human aging is associated with remodeling of the immune system. While most studies on immunosenescence have focused on adaptive immunity, the effects of aging on innate immunity are not well understood. Here, we investigated whether aging affects cytokine responses to a wide range of well
- PMID 26944367
- Vibrio elicits targeted transcriptional responses from copepod hosts.
- Almada AA1, Tarrant AM2.
- FEMS microbiology ecology.FEMS Microbiol Ecol.2016 Jun;92(6). pii: fiw072. doi: 10.1093/femsec/fiw072. Epub 2016 Apr 6.
- Copepods are abundant crustaceans that harbor diverse bacterial communities, yet the nature of their interactions with microbiota are poorly understood. Here, we report that Vibrio elicits targeted transcriptional responses in the estuarine copepod Eurytemora affinis We pre-treated E. affinis with a
- PMID 27056917
Japanese Journal
- アレルギー炎症におけるpathogenとdanger signalの役割
- C型レクチンによる「異常自己」と「非自己病原体」の認識と意義
- Galactose recognition by a tetrameric C-type lectin, CEL-IV, containing the EPN carbohydrate recognition motif.
- Hatakeyama Tomomitsu,Kamiya Takuro,Kusunoki Masami,Nakamura-Tsuruta Sachiko,Hirabayashi Jun,Goda Shuichiro,Unno Hideaki
- The Journal of Biological Chemistry 286(12), 10305-10315, 2011-03-25
- … CEL-IV is a C-type lectin isolated from a sea cucumber, Cucumaria echinata. … This lectin is composed of four identical C-type carbohydrate-recognition domains (CRDs). …
- NAID 120003037543
Related Links
- C-type lectin receptors (CLRs) comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. The lectin activity of these receptors is mediated by conserved carbohydrate-recognition domains (CRDs).
- C-type lectins are CA++-dependent glycan-binding proteins that share primary and secondary structural homology in their carbohydrate-recognition domains (CRDs). These proteins have a C-type lectin fold, which is a fold with highly ...
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- NKRP1, NKRP-1
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セシウム, caesium, cesium