B-cell activation factor receptor

B細胞活性化因子受容体、B細胞活性化因子レセプター

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. small room in which a monk or nun lives (同)cubicle
8. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
9. a room where a prisoner is kept (同)jail cell, prison cell
10. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
11. any small compartment; "the cells of a honeycomb"
12. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
13. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
14. a concept whose truth can be proved; "scientific hypotheses are not facts"
15. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
16. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
17. the 2nd letter of the Roman alphabet (同)b
18. the blood group whose red cells carry the B antigen (同)type_B, group B
19. making active and effective (as a bomb)
20. stimulation of activity in an organism or chemical

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
4. 活動化 / (物質の)活性化(化学反応を起こしやすくすること)

UpToDate Contents

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• 1. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
• 2. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
• 3. 複合免疫不全 combined immunodeficiencies
• 4. 非ホジキンリンパ腫の病理の概要 overview of the pathobiology of the non hodgkin lymphomas
• 5. びまん性大細胞型B細胞性リンパ腫および原発性縦隔大細胞型B細胞リンパ腫の病理学 pathobiology of diffuse large b cell lymphoma and primary mediastinal large b cell lymphoma

English Journal

• The synergistic effect of BCR signaling inhibitors combined with an HDAC inhibitor on cell death in a mantle cell lymphoma cell line.

• Hagiwara K1, Kunishima S, Iida H, Miyata Y, Naoe T, Nagai H.
• Apoptosis : an international journal on programmed cell death.Apoptosis.2015 Jul;20(7):975-85. doi: 10.1007/s10495-015-1125-1.
• Mantle cell lymphoma (MCL) is a B cell malignancy characterized by aberrant expression of cyclin D1 due to a t(11;14) translocation. MCL is refractory to conventional chemotherapy, and treatment remains challenging. We investigated the efficacy of the histone deacetylase (HDAC) inhibitor vorinostat
• PMID 25835755

• Cocaine mediated microglial activation involves the ER stress-Autophagy axis.

• Guo ML1, Liao K, Periyasamy P, Yang L, Cai Y, Callen SE, Buch S.
• Autophagy.Autophagy.2015 Jun 4:0. [Epub ahead of print]
• Cocaine abuse leads to neuroinflammation, which in turn, contributes to the pathogenesis of neurodegeneration associated with advanced HIV-1 infection. Autophagy plays important roles in both innate and adaptive immune responses. However, the possible functional link between cocaine and autophagy ha
• PMID 26043790

• TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.

• Villanueva JE1, Malle EK1, Gardam S2, Silveira PA3, Zammit NW1, Walters SN1, Brink R2, Grey ST1.
• European journal of immunology.Eur J Immunol.2015 Jun;45(6):1820-31. doi: 10.1002/eji.201445416. Epub 2015 May 26.
• In this study, a critical and novel role for TNF receptor (TNFR) associated factor 2 (TRAF2) is elucidated for peripheral CD8(+) T-cell and NKT-cell homeostasis. Mice deficient in TRAF2 only in their T cells (TRAF2TKO) show ∼40% reduction in effector memory and ∼50% reduction in naïve CD8(+) T-
• PMID 25931426

Japanese Journal

• Tumor Microenvironment and RIG-I Signaling Molecules in Epstein Barr Virus-Positive and -Negative Classical Hodgkin Lymphoma of the Elderly

• Satoh Tsugumi,Wada Ryuichi,Yajima Nobuhisa,Imaizumi Tadaatsu,Yagihashi Soroku
• Journal of Clinical and Experimental Hematopathology 54(1), 75-84, 2014
• … Classical Hodgkin lymphoma (CHL) is a B-cell neoplasm characterized by Hodgkin and Reed-Sternberg (HRS) cells. … cells, while that of granzyme B<SUP>+</SUP> …
• NAID 130004886479

• 亜鉛トランスポーターZIP9によるB細胞受容体シグナルの活性化制御

• 谷口 将済,榎本 秀一,廣村 信
• 薬学雑誌. 乙号 134(7), 809-812, 2014
• … Zinc functions not only as a nutritional factor, but also as a second messenger. … However, the effects of intracellular zinc on the B cell-receptor (BCR) signaling pathway are not poorly understood. … Here, we indicate that the ZIP9 induces increase in intracellular zinc level and plays an important role in the phosphorylation of Akt and Erk in response to BCR activation. …
• NAID 130004756449

• インターロイキン1：細胞増殖制御から慢性炎症性疾患まで

• 小野嵜 菊夫
• 薬学雑誌. 乙号 133(6), 645-660, 2013
• …   Interleukin 1 (IL-1) was initially defined as a factor which is produced by macrophages and exhibits proliferative activity on thymocytes and fibroblasts, B cell activation and endogenous pyrogen activity. …
• NAID 130003361960

Related Links

• B-cell activating factor-receptor specific activation of tumor ...

1. Leuk Lymphoma. 2014 Aug;55(8):1884-92. doi: 10.3109/10428194.2013.862619. Epub 2014 Feb 24. B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl ...

• B cell-activating factor belonging to the TNF family (BAFF)-R ...

1. J Immunol. 2004 Jul 15;173(2):807-17. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. Ng LG(1), Sutherland AP, Newton R ...

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★リンクテーブル★

リンク元	「B細胞活性化因子受容体」「B細胞活性化因子レセプター」
関連記事	「B」「fact」「factor」「activation」「cell」

「B細胞活性化因子受容体」

　　[★]

英

B-cell activation factor receptor

関

B細胞活性化因子レセプター

「B細胞活性化因子レセプター」

　　[★]

英

B-cell activation factor receptor

関

B細胞活性化因子受容体

「B」

　　[★]

• 気管分岐部下緑
• 補体のalternative pathwayに関わる蛋白質

• Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「activation」

　　[★]

• 活性化、賦活化、賦活

関

activate、activated、turn on

　 　 　

「cell」

　　[★] 細胞