WordNet

invest with or as with a body; give body to (同)personify
the external structure of a vehicle; "the body of the car was badly rusted"
the main mass of a thing
a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
the central message of a communication; "the body of the message was short"

PrepTutorEJDIC

〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
goldの化学記号
《英話》人;(特に)男

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/01 09:18:34」(JST)

wiki en

Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts

Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of myeloid leukemic blasts. They can be seen in the leukemic blasts of acute myeloid leukemia with maturation and acute promyelocytic leukemia (respectively known as acute myeloid leukemia M2 and M3 in the FAB classification) and in high grade myelodysplastic syndromes and myeloproliferative syndromes. They are composed of fused lysosomes/primary neutrophilic granules and contain peroxidase, lysosomal enzymes, and large crystalline inclusions. Morphologically, the Auer "rods" come in all sizes and shapes. They have been described as needle-shapes with pointed ends (most common), comma-shapes, and diamond-shapes; others were long and rectangular. Occasional corkscrew forms and rare granular Auer bodies were also noted. More appropriately, they can be referred to as Auer bodies.^[1]

They are also used to distinguish the pre-leukemia myelodysplastic syndromes: refractory anemia with excess blasts 2 (which has Auer rods) from RAEB 1 (which does not). However, rare cases of RAEB1 show rare Auer rods, and when they do, they have a worse prognosis.

Eponym

These cytoplasmic inclusions are named for John Auer, a US physiologist (1875-1948).^[2]

However, they were first described in 1905 by a Canadian physician, Thomas McCrae, then at The Johns Hopkins Hospital,^[3] one year before Auer, as acknowledged in Auer's article. Both McCrae and Auer mistakenly thought that the cells containing the rods were lymphoblasts.^[4]

Additional images

References

^ http://bloodjournal.hematologylibrary.org/content/5/9/847.full.pdf+html
^ Auer, John (1906). "Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia". American Journal of the Medical Sciences. 131 (6): 1002–1015. ISSN 0002-9629. doi:10.1097/00000441-190606000-00008.
^ McCrae, Thomas (February 1905). "Acute lymphatic leukaemia with a report of five cases". British Medical Journal. 1 (2304): 404–408. PMC 2319598 . PMID 20761949. doi:10.1136/bmj.1.2304.404.
^ Bain, Barbara (August 2011). "Auer rods or McCrae rods?". American Journal of Hematology. 86 (8): 689. PMID 21761434. doi:10.1002/ajh.21978.

External links

Image at NIH/MedlinePlus
Slides at wadsworth.org
Image at University of Utah

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
2. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
3. Overview of acute myeloid leukemia in adults
4. 成人における抗癌剤の投与 dosing of anticancer agents in adults
5. Clinical assessment of walking and running gait

English Journal

Prognosis of Patients With Familial Hypercholesterolemia After Acute Coronary Syndromes.

Nanchen D1, Gencer B2, Muller O2, Auer R2, Aghlmandi S2, Heg D2, Klingenberg R2, Räber L2, Carballo D2, Carballo S2, Matter CM2, Lüscher TF2, Windecker S2, Mach F2, Rodondi N2.
Circulation.Circulation.2016 Sep 6;134(10):698-709. doi: 10.1161/CIRCULATIONAHA.116.023007. Epub 2016 Jul 26.
BACKGROUND: Patients with heterozygous familial hypercholesterolemia (FH) and coronary heart disease have high mortality rates. However, in an era of high-dose statin prescription after acute coronary syndrome (ACS), the risk of recurrent coronary and cardiovascular events associated with FH might b
PMID 27462068

Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies.

Tanasescu R1, Cottam WJ2, Condon L2, Tench CR3, Auer DP4.
Neuroscience and biobehavioral reviews.Neurosci Biobehav Rev.2016 Sep;68:120-33. doi: 10.1016/j.neubiorev.2016.04.001. Epub 2016 May 7.
Maladaptive mechanisms of pain processing in chronic pain conditions (CP) are poorly understood. We used coordinate based meta-analysis of 266 fMRI pain studies to study functional brain reorganisation in CP and experimental models of hyperalgesia. The pattern of nociceptive brain activation was sim
PMID 27168346

Chédiak-Higashi-like granules and waxy Auer bodies in a case of acute promyelocytic leukemia.

Ogiya D1, Matsushita H2,3, Murayama H1, Ando K1.
International journal of hematology.Int J Hematol.2016 Aug 18. [Epub ahead of print]
PMID 27539154

Japanese Journal

急性白血病FAB分類の問題点 : 特にリンパ球系白血病細胞と骨髄系白血病細胞の鑑別について

中村忍,中西二,吉田喬,大竹茂樹,伊藤恵子,小林和美,松田保
日本臨床細胞学会雑誌 25(6), 1003-1009, 1986-11-20
NAID 110001282573

Electron microscopic study of the Auer body

Fukushi Katsuhisa [他]
Acta Pathologica Japonica 22(3), 509-515, 1972-08
NAID 40018695414

Related Pictures

★リンクテーブル★

リンク元	「アウエル小体」
関連記事	「body」「Au」

「アウエル小体」

　　[★]

英: Auer body, Auer's body, Auer rod
同: Auer小体
関

A rod-shaped structure of uncertain nature in the cytoplasm of immature myeloid cells, especially myeloblasts, in cases of acute myelocytic leukemia. Also called Auer rod.

ギムザ染色された標本中において、未熟な骨髄系の細胞(myeloid cell)、特に急性骨髄性白血病において骨髄芽球の細胞質にみられる桿状体。赤色に染まっており、ペルオキシダーゼ陽性である。
骨髄異形成症候群ではみられない事が多い、らしいが(YN.G-51 tableより)、急性骨髄性白血病(AML)ではみられる。　⇔　慢性骨髄性白血病(CML)ではみられない (QB.G-245)

AML(M1,M2), APL(M3), AMoL(M5)ではAuer小体がみられる(QB.G-244)

ペルオキシダーゼ染色に陽性であり、アズール顆粒由来と考えられている。

「body」

　　[★]

n.

体、本体、身体、ボディー

「Au」

　　[★]

金

関: gold、golden

[1] ttp://bloodjournal.hematologylibrary.org/content/5/9/847.full.pdf+html

[2] Auer, John (1906). "Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia". American Journal of the Medical Sciences. 131 (6): 1002–1015. ISSN 0002-9629. doi:10.1097/00000441-190606000-00008.

[3] McCrae, Thomas (February 1905). "Acute lymphatic leukaemia with a report of five cases". British Medical Journal. 1 (2304): 404–408. PMC 2319598 . PMID 20761949. doi:10.1136/bmj.1.2304.404.

[4] Bain, Barbara (August 2011). "Auer rods or McCrae rods?". American Journal of Hematology. 86 (8): 689. PMID 21761434. doi:10.1002/ajh.21978.

v t e Eponymous medical signs for oncology
Hematological malignancy	Russell bodies Auer rod Bence Jones protein
Lymph nodes	Virchow's node (Troisier's sign) Sister Mary Joseph nodule Lund's node
Other	Call-Exner bodies Leser–Trélat sign Trousseau sign of malignancy Courvoisier's law Schiller–Duval body

v t e Eponymous medical signs for hematology
Inclusion bodies	Red blood cell Cabot rings Howell–Jolly body Pappenheimer bodies Heinz body Neutrophil Döhle bodies Plasma cell Russell bodies Myeloblast Auer rod Histiocyte Birbeck granules
Tests	Apt test Coombs test
Other	Arneth count Mentzer index Virchow's triad Anaemia Pagophagia

匿名

検索

案内

案内

Auer body