アウエル小体
WordNet
- invest with or as with a body; give body to (同)personify
- the external structure of a vehicle; "the body of the car was badly rusted"
- the main mass of a thing
- a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
- the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
- a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
- a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
- an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
- the central message of a communication; "the body of the message was short"
PrepTutorEJDIC
- 〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
- goldの化学記号
- 《英話》人;(特に)男
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/09/01 09:18:34」(JST)
[Wiki en表示]
Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts
Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of myeloid leukemic blasts. They can be seen in the leukemic blasts of acute myeloid leukemia with maturation and acute promyelocytic leukemia (respectively known as acute myeloid leukemia M2 and M3 in the FAB classification) and in high grade myelodysplastic syndromes and myeloproliferative syndromes. They are composed of fused lysosomes/primary neutrophilic granules and contain peroxidase, lysosomal enzymes, and large crystalline inclusions. Morphologically, the Auer "rods" come in all sizes and shapes. They have been described as needle-shapes with pointed ends (most common), comma-shapes, and diamond-shapes; others were long and rectangular. Occasional corkscrew forms and rare granular Auer bodies were also noted. More appropriately, they can be referred to as Auer bodies.[1]
They are also used to distinguish the pre-leukemia myelodysplastic syndromes: refractory anemia with excess blasts 2 (which has Auer rods) from RAEB 1 (which does not). However, rare cases of RAEB1 show rare Auer rods, and when they do, they have a worse prognosis.
Contents
- 1 Eponym
- 2 Additional images
- 3 References
- 4 External links
Eponym
These cytoplasmic inclusions are named for John Auer, a US physiologist (1875-1948).[2]
However, they were first described in 1905 by a Canadian physician, Thomas McCrae, then at The Johns Hopkins Hospital,[3] one year before Auer, as acknowledged in Auer's article. Both McCrae and Auer mistakenly thought that the cells containing the rods were lymphoblasts.[4]
Additional images
References
- ^ http://bloodjournal.hematologylibrary.org/content/5/9/847.full.pdf+html
- ^ Auer, John (1906). "Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia". American Journal of the Medical Sciences. 131 (6): 1002–1015. ISSN 0002-9629. doi:10.1097/00000441-190606000-00008.
- ^ McCrae, Thomas (February 1905). "Acute lymphatic leukaemia with a report of five cases". British Medical Journal. 1 (2304): 404–408. PMC 2319598 . PMID 20761949. doi:10.1136/bmj.1.2304.404.
- ^ Bain, Barbara (August 2011). "Auer rods or McCrae rods?". American Journal of Hematology. 86 (8): 689. PMID 21761434. doi:10.1002/ajh.21978.
External links
- Image at NIH/MedlinePlus
- Slides at wadsworth.org
- Image at University of Utah
Eponymous medical signs for oncology
|
Hematological malignancy |
- Russell bodies
- Auer rod
- Bence Jones protein
|
Lymph nodes |
- Virchow's node (Troisier's sign)
- Sister Mary Joseph nodule
- Lund's node
|
Other |
- Call-Exner bodies
- Leser–Trélat sign
- Trousseau sign of malignancy
- Courvoisier's law
- Schiller–Duval body
|
Eponymous medical signs for hematology
|
Inclusion bodies |
- Red blood cell
- Cabot rings
- Howell–Jolly body
- Pappenheimer bodies
- Heinz body
- Neutrophil
- Plasma cell
- Myeloblast
- Histiocyte
|
Tests |
|
Other |
- Arneth count
- Mentzer index
- Virchow's triad
- Anaemia
|
UpToDate Contents
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English Journal
- Prognosis of Patients With Familial Hypercholesterolemia After Acute Coronary Syndromes.
- Nanchen D1, Gencer B2, Muller O2, Auer R2, Aghlmandi S2, Heg D2, Klingenberg R2, Räber L2, Carballo D2, Carballo S2, Matter CM2, Lüscher TF2, Windecker S2, Mach F2, Rodondi N2.
- Circulation.Circulation.2016 Sep 6;134(10):698-709. doi: 10.1161/CIRCULATIONAHA.116.023007. Epub 2016 Jul 26.
- BACKGROUND: Patients with heterozygous familial hypercholesterolemia (FH) and coronary heart disease have high mortality rates. However, in an era of high-dose statin prescription after acute coronary syndrome (ACS), the risk of recurrent coronary and cardiovascular events associated with FH might b
- PMID 27462068
- Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies.
- Tanasescu R1, Cottam WJ2, Condon L2, Tench CR3, Auer DP4.
- Neuroscience and biobehavioral reviews.Neurosci Biobehav Rev.2016 Sep;68:120-33. doi: 10.1016/j.neubiorev.2016.04.001. Epub 2016 May 7.
- Maladaptive mechanisms of pain processing in chronic pain conditions (CP) are poorly understood. We used coordinate based meta-analysis of 266 fMRI pain studies to study functional brain reorganisation in CP and experimental models of hyperalgesia. The pattern of nociceptive brain activation was sim
- PMID 27168346
- Chédiak-Higashi-like granules and waxy Auer bodies in a case of acute promyelocytic leukemia.
- Ogiya D1, Matsushita H2,3, Murayama H1, Ando K1.
- International journal of hematology.Int J Hematol.2016 Aug 18. [Epub ahead of print]
- PMID 27539154
Japanese Journal
- 急性白血病FAB分類の問題点 : 特にリンパ球系白血病細胞と骨髄系白血病細胞の鑑別について
- 中村 忍,中西 二,吉田 喬,大竹 茂樹,伊藤 恵子,小林 和美,松田 保
- 日本臨床細胞学会雑誌 25(6), 1003-1009, 1986-11-20
- NAID 110001282573
- Electron microscopic study of the Auer body
- Fukushi Katsuhisa [他]
- Acta Pathologica Japonica 22(3), 509-515, 1972-08
- NAID 40018695414
Related Links
- 世界大百科事典 第2版 - Auer bodyの用語解説 - これらの幼若な白血病の白血球は,正常骨髄に存在する同じ成熟段階の細胞と比べると,細胞の大きさ,核の型,核が細胞中で占める割合,細胞質の色調,顆粒の形や大きさ,などの点で ...
- 一面に芽球が認められる。芽球のほとんどは、細胞質内に赤紫色の顆粒を持っている。赤紫色で、針状のアウエル小体(Auer body)も見られる。無数のアウエル小体を充満させている芽球が認められる。このような細胞をファゴット細胞 ...
Related Pictures
![小体(Auer body)も見られる](https://1mg.info/0/9/y/1323.jpg)
![Acute-Granulocytic-Leukemia-Auer-Body.jpg](https://1mg.info/0/9/y/1324.jpg)
![auer rod 1000x auer body](https://1mg.info/0/9/y/1325.jpg)
![of AML do you see the most Auer rods](https://1mg.info/0/9/y/1327.jpg)
![AML~結晶auer body所以是AML不是ALL](https://1mg.info/0/9/y/1328.jpg)
★リンクテーブル★
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- 英
- Auer body, Auer's body, Auer rod
- 同
- Auer小体
- 関
- A rod-shaped structure of uncertain nature in the cytoplasm of immature myeloid cells, especially myeloblasts, in cases of acute myelocytic leukemia. Also called Auer rod.
- ギムザ染色された標本中において、未熟な骨髄系の細胞(myeloid cell)、特に急性骨髄性白血病において骨髄芽球の細胞質にみられる桿状体。赤色に染まっており、ペルオキシダーゼ陽性である。
- 骨髄異形成症候群ではみられない事が多い、らしいが(YN.G-51 tableより)、急性骨髄性白血病(AML)ではみられる。 ⇔ 慢性骨髄性白血病(CML)ではみられない (QB.G-245)
- AML(M1,M2), APL(M3), AMoL(M5)ではAuer小体がみられる(QB.G-244)
- ペルオキシダーゼ染色に陽性であり、アズール顆粒由来と考えられている。
[★]
[★]
金
- 関
- gold、golden