WordNet

a long thin implement made of metal or wood
any rod-shaped bacterium
a visual receptor cell that is sensitive to dim light (同)rod_cell, retinal rod

PrepTutorEJDIC

(木製・金属製などの)『棒,つえ』,さお;釣りざお / (刑罰に用いる)木のむち;《the ~》むち打ち,せっかん / ロッド(長さの単位;『5』1/2yards,約5m) / (目の)桿(かん)状体(弱い光にも感じる網膜細胞) / 《米俗》ピストル
goldの化学記号
roentgen / recto

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/03/01 10:51:45」(JST)

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Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts

Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of myeloid leukemic blasts. They can be seen in the leukemic blasts of acute myeloid leukemia with maturation and acute promyelocytic leukemia (respectively known as acute myeloid leukemia M2 and M3 in the FAB classification) and in high grade myelodysplastic syndromes and myeloproliferative syndromes. They are composed of fused lysosomes/primary neutrophilic granules and contain peroxidase, lysosomal enzymes, and large crystalline inclusions. Morphologically, the Auer "rods" come in all sizes and shapes. They have been described as needle-shapes with pointed ends (most common), comma-shapes, and diamond-shapes; others were long and rectangular. Occasional corkscrew forms and rare granular Auer bodies were also noted. More appropriately, they can be referred to as Auer bodies.^[1]

They are also used to distinguish the pre-leukemia myelodysplastic syndromes: refractory anemia with excess blasts 2 (which has Auer rods) from RAEB 1 (which does not). However, rare cases of RAEB1 show rare Auer rods, and when they do, they have a worse prognosis.

Eponym

These cytoplasmic inclusions are named for John Auer, a US physiologist (1875-1948).^[2]

However, they were first described in 1905 by a Canadian physician, Thomas McCrae, then at The Johns Hopkins Hospital,^[3] one year before Auer, as acknowledged in Auer's article. Both McCrae and Auer mistakenly thought that the cells containing the rods were lymphoblasts.^[4]

Additional images

References

^ http://bloodjournal.hematologylibrary.org/content/5/9/847.full.pdf+html
^ Auer, John (1906). "Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia". American Journal of the Medical Sciences. 131 (6): 1002–1015. doi:10.1097/00000441-190606000-00008. ISSN 0002-9629.
^ McCrae, Thomas (February 1905). "Acute lymphatic leukaemia with a report of five cases". British Medical Journal. 1 (2304): 404–408. doi:10.1136/bmj.1.2304.404. PMC 2319598 . PMID 20761949.
^ Bain, Barbara (August 2011). "Auer rods or McCrae rods?". American Journal of Hematology. 86 (8): 689. doi:10.1002/ajh.21978. PMID 21761434.

External links

Image at NIH/MedlinePlus
Slides at wadsworth.org
Image at University of Utah

UpToDate Contents

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1. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
2. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
3. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
4. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears
5. 慢性骨髄単球性白血病 chronic myelomonocytic leukemia

English Journal

Auer Rod in a Neutrophil in a Nonmalignant Condition.

Chandra H1, Chandra S, Gupta V, Mahajan D.
Turkish journal of haematology : official journal of Turkish Society of Haematology.Turk J Haematol.2016 Jun 5;33(2):167. doi: 10.4274/tjh.2015.0275. Epub 2016 Apr 18.
PMID 27094025

Comment: In response to "Auer rod like inclusions in reactive plasma cells in a case of acute myeloid leukemia".

Gajendra S.
Turkish journal of haematology : official journal of Turkish Society of Haematology.Turk J Haematol.2016 Apr 18. doi: 10.4274/tjh.2016.0139. [Epub ahead of print]
PMID 27095281

Auer rod like inclusions in reactive plasma cells in a case of acute myeloid leukemia.

Pradhan S.
Turkish journal of haematology : official journal of Turkish Society of Haematology.Turk J Haematol.2016 Apr 18. doi: 10.4274/tjh.2015.0399. [Epub ahead of print]
A 61years old female presented with decreasing hemoglobin for past 6 months. She had a history of multiple transfusions in the recent past. Laboratory investigations showed: hemoglobin of 8.6 g/dL, total blood leukocyte count of 1.13 x109/L, and platelets of 80x109/L with presence of occasional circ
PMID 27095070

Japanese Journal

Auer rod-like cytoplasmic inclusion bodies in nodal marginal zone lymphoma cells

TAKAHASHI Toru,SUZUKAWA Munehiro,AKIYAMA Masaru,HATAO Katsuhiro
International journal of hematology 89(2), 133-134, 2009-03-15
NAID 10025159984

Ａｕｅｒ小体様の封入体を認めたｐｌａｓｍａ　ｃｅｌｌ　ｄｙｓｃｒａｓｉａの１例

小林昭一,山本敏晴,秋葉千代美,片山典子,坂井慶子,丸田壱郎,小川浩司,藤沢信,酒井リカ,田口淳,富田直人,児玉文雄
臨床血液 35(7), 713-716, 1994
… Auer-rod-like bodies were found in plasma cells from a 74-year-old man with plasma cell dyscrasia. … These bodies exhibited red purple staining by May-Giemsa staining and were indistinguishable from Auer bodies often found in acute myeloid leukemia. … The Auer-rod-like bodies were found in 0.05% (2/3824), 0.07% (4/6883) and 0.08% (2/2656) of the plasma cells. …
NAID 130004500103

Ｐｈ｀１´染色体陽性ｂｃｒ再構成陽性の巨核芽球性白血病へ移行した小児骨髄異形成症候群（ＲＡＥＢｔ）の１例

稲葉俊哉,林泰秀,細谷静恵,花田良二,山本圭子,西田俊朗,中村こずえ,水谷修紀,杉田完爾,中澤真平,江口光興
臨床血液 31(7), 994-998, 1990
… His bone marrow was normocellular with 18% blasts, which had Auer rod and were positive for peroxidase staining. …
NAID 130004499696

Related Pictures

★リンクテーブル★

リンク元	「アウエル小体」
関連記事	「ROD」「rods」「Au」

「アウエル小体」

　　[★]

英: Auer body, Auer's body, Auer rod
同: Auer小体
関

A rod-shaped structure of uncertain nature in the cytoplasm of immature myeloid cells, especially myeloblasts, in cases of acute myelocytic leukemia. Also called Auer rod.

ギムザ染色された標本中において、未熟な骨髄系の細胞(myeloid cell)、特に急性骨髄性白血病において骨髄芽球の細胞質にみられる桿状体。赤色に染まっており、ペルオキシダーゼ陽性である。
骨髄異形成症候群ではみられない事が多い、らしいが(YN.G-51 tableより)、急性骨髄性白血病(AML)ではみられる。　⇔　慢性骨髄性白血病(CML)ではみられない (QB.G-245)

AML(M1,M2), APL(M3), AMoL(M5)ではAuer小体がみられる(QB.G-244)

ペルオキシダーゼ染色に陽性であり、アズール顆粒由来と考えられている。

「ROD」

　　[★] 腎性骨ジストロフィー腎性骨異栄養症 renal osteodystrophy。腎性骨症

「rods」

　　[★]

同: eye

同: vision

同: eye

「Au」

　　[★]

金

関: gold、golden

[1] ttp://bloodjournal.hematologylibrary.org/content/5/9/847.full.pdf+html

[2] Auer, John (1906). "Some hitherto undescribed structures found in the large lymphocytes of a case of acute leukaemia". American Journal of the Medical Sciences. 131 (6): 1002–1015. doi:10.1097/00000441-190606000-00008. ISSN 0002-9629.

[3] McCrae, Thomas (February 1905). "Acute lymphatic leukaemia with a report of five cases". British Medical Journal. 1 (2304): 404–408. doi:10.1136/bmj.1.2304.404. PMC 2319598 . PMID 20761949.

[4] Bain, Barbara (August 2011). "Auer rods or McCrae rods?". American Journal of Hematology. 86 (8): 689. doi:10.1002/ajh.21978. PMID 21761434.

v t e Eponymous medical signs for oncology
Hematological malignancy	Russell bodies Auer rod Bence Jones protein
Lymph nodes	Troisier's sign (Virchow's node) Sister Mary Joseph nodule Lund's node
Other	Call-Exner bodies Leser–Trélat sign Trousseau sign of malignancy Courvoisier's law Schiller–Duval body

v t e Eponymous medical signs for hematology
Inclusion bodies	Red blood cell Cabot rings Howell–Jolly body Pappenheimer bodies Heinz body Neutrophil Döhle bodies Plasma cell Russell bodies Myeloblast Auer rod Histiocyte Birbeck granules
Tests	Apt test Coombs test
Other	Arneth count Mentzer index Virchow's triad Anaemia Pagophagia

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Auer rod