ADPリボシル化因子1、ADP-リボシル化因子1
- 関
- ARF1
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- answer / ampere
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/27 16:52:20」(JST)
[Wiki en表示]
ADP-ribosylation factor 1 |
PDB rendering based on 1hur. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1HUR, 1RE0, 1U81, 3O47
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Identifiers |
Symbol |
ARF1 |
External IDs |
OMIM: 103180 MGI: 99431 HomoloGene: 56086 ChEMBL: 5985 GeneCards: ARF1 Gene |
Gene Ontology |
Molecular function |
• GTPase activity
• receptor signaling protein activity
• protein binding
• GTP binding
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Cellular component |
• Golgi membrane
• cytosol
• plasma membrane
• sarcomere
• perinuclear region of cytoplasm
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Biological process |
• GTP catabolic process
• cellular copper ion homeostasis
• retrograde vesicle-mediated transport, Golgi to ER
• post-Golgi vesicle-mediated transport
• small GTPase mediated signal transduction
• protein transport
• viral reproduction
• cellular membrane organization
• COPI coating of Golgi vesicle
• regulation of defense response to virus by virus
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
375 |
11841 |
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Ensembl |
ENSG00000143761 |
ENSMUSG00000062421 |
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UniProt |
P84077 |
Q8BSL7 |
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RefSeq (mRNA) |
NM_001024226.1 |
NM_007477.4 |
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RefSeq (protein) |
NP_001019397.1 |
NP_031503.1 |
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Location (UCSC) |
Chr 1:
228.27 – 228.29 Mb |
Chr 11:
103.97 – 103.99 Mb |
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PubMed search |
[1] |
[2] |
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ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.[1]
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]
Interactions
ARF1 has been shown to interact with GGA3,[3][4] PLD2,[5][6] COPB1[7][8] and Muscarinic acetylcholine receptor M3.[9]
References
- ^ Lee CM, Haun RS, Tsai SC, Moss J, Vaughan M (June 1992). "Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin". J Biol Chem 267 (13): 9028–34. PMID 1577740.
- ^ "Entrez Gene: ARF1 ADP-ribosylation factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=375.
- ^ Dell'Angelica, E C; Puertollano R, Mullins C, Aguilar R C, Vargas J D, Hartnell L M, Bonifacino J S (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. (UNITED STATES) 149 (1): 81–94. doi:10.1083/jcb.149.1.81. ISSN 0021-9525. PMC 2175099. PMID 10747089. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2175099/.
- ^ Puertollano, R; Randazzo P A, Presley J F, Hartnell L M, Bonifacino J S (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell (United States) 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. ISSN 0092-8674. PMID 11301005.
- ^ Lee, S; Park J B, Kim J H, Kim Y, Kim J H, Shin K J, Lee J S, Ha S H, Suh P G, Ryu S H (July 2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. (United States) 276 (30): 28252–60. doi:10.1074/jbc.M008521200. ISSN 0021-9258. PMID 11373276.
- ^ Park, J B; Kim J H, Kim Y, Ha S H, Yoo J S, Du G, Frohman M A, Suh P G, Ryu S H (July 2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. (UNITED STATES) 275 (28): 21295–301. doi:10.1074/jbc.M002463200. ISSN 0021-9258. PMID 10801846.
- ^ Fischer, K D; Helms J B, Zhao L, Wieland F T (April 2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles". Methods (UNITED STATES) 20 (4): 455–64. doi:10.1006/meth.2000.0958. ISSN 1046-2023. PMID 10720466.
- ^ Eugster, A; Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. (ENGLAND) 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. ISSN 0261-4189. PMC 306616. PMID 10921873. //www.ncbi.nlm.nih.gov/pmc/articles/PMC306616/.
- ^ Mitchell, Rory; Robertson Derek N, Holland Pamela J, Collins Daniel, Lutz Eve M, Johnson Melanie S (September 2003). "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. (United States) 278 (36): 33818–30. doi:10.1074/jbc.M305825200. ISSN 0021-9258. PMID 12799371.
Further reading
- Serafini T, Orci L, Amherdt M, et al. (1991). "ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein.". Cell 67 (2): 239–53. doi:10.1016/0092-8674(91)90176-Y. PMID 1680566.
- Kahn RA, Kern FG, Clark J, et al. (1991). "Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins.". J. Biol. Chem. 266 (4): 2606–14. PMID 1899243.
- Stearns T, Willingham MC, Botstein D, Kahn RA (1990). "ADP-ribosylation factor is functionally and physically associated with the Golgi complex.". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1238–42. doi:10.1073/pnas.87.3.1238. PMC 53446. PMID 2105501. //www.ncbi.nlm.nih.gov/pmc/articles/PMC53446/.
- Bobak DA, Nightingale MS, Murtagh JJ, et al. (1989). "Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.". Proc. Natl. Acad. Sci. U.S.A. 86 (16): 6101–5. doi:10.1073/pnas.86.16.6101. PMC 297783. PMID 2474826. //www.ncbi.nlm.nih.gov/pmc/articles/PMC297783/.
- Greasley SE, Jhoti H, Teahan C, et al. (1995). "The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.". Nat. Struct. Biol. 2 (9): 797–806. doi:10.1038/nsb0995-797. PMID 7552752.
- Welsh CF, Moss J, Vaughan M (1995). "ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.". Mol. Cell. Biochem. 138 (1–2): 157–66. doi:10.1007/BF00928458. PMID 7898460.
- Greasley S, Jhoti H, Fensome AC, et al. (1995). "Crystallization and preliminary X-ray diffraction studies on ADP-ribosylation factor 1". J. Mol. Biol. 244 (5): 651–3. doi:10.1006/jmbi.1994.1759. PMID 7990146.
- Amor JC, Harrison DH, Kahn RA, Ringe D (1995). "Structure of the human ADP-ribosylation factor 1 complexed with GDP". Nature 372 (6507): 704–8. doi:10.1038/372704a0. PMID 7990966.
- Dascher C, Balch WE (1994). "Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus". J. Biol. Chem. 269 (2): 1437–48. PMID 8288610.
- Rümenapp U, Geiszt M, Wahn F, et al. (1996). "Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor". Eur. J. Biochem. 234 (1): 240–4. doi:10.1111/j.1432-1033.1995.240_c.x. PMID 8529647.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hirai M, Kusuda J, Hashimoto K (1997). "Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively". Genomics 34 (2): 263–5. doi:10.1006/geno.1996.0283. PMID 8661066.
- Kanoh H, Williger BT, Exton JH (1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J. Biol. Chem. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139146/.
- Shome K, Vasudevan C, Romero G (1997). "ARF proteins mediate insulin-dependent activation of phospholipase D". Curr. Biol. 7 (6): 387–96. doi:10.1016/S0960-9822(06)00186-2. PMID 9197239.
- Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. doi:10.1074/jbc.273.1.23. PMID 9417041.
- Betz SF, Schnuchel A, Wang H, et al. (1998). "Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 7909–14. doi:10.1073/pnas.95.14.7909. PMC 20903. PMID 9653114. //www.ncbi.nlm.nih.gov/pmc/articles/PMC20903/.
- Kim JH, Lee SD, Han JM, et al. (1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Lett. 430 (3): 231–5. doi:10.1016/S0014-5793(98)00661-9. PMID 9688545.
- Huber I, Cukierman E, Rotman M, et al. (1998). "Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein". J. Biol. Chem. 273 (38): 24786–91. doi:10.1074/jbc.273.38.24786. PMID 9733781.
PDB gallery
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1hur: HUMAN ADP-RIBOSYLATION FACTOR 1 COMPLEXED WITH GDP, FULL LENGTH NON-MYRISTOYLATED
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1j2j: Crystal structure of GGA1 GAT N-terminal region in complex with ARF1 GTP form
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1o3y: Crystal structure of mouse ARF1 (delta17-Q71L), GTP form
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1r8q: FULL-LENGTH ARF1-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN
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1r8s: ARF1[DELTA1-17]-GDP IN COMPLEX WITH A SEC7 DOMAIN CARRYING THE MUTATION OF THE CATALYTIC GLUTAMATE TO LYSINE
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1re0: Structure of ARF1-GDP bound to Sec7 domain complexed with Brefeldin A
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1rrf: NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, MONOMERIC CRYSTAL FORM
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1rrg: NON-MYRISTOYLATED RAT ADP-RIBOSYLATION FACTOR-1 COMPLEXED WITH GDP, DIMERIC CRYSTAL FORM
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1s9d: ARF1[DELTA 1-17]-GDP-MG IN COMPLEX WITH BREFELDIN A AND A SEC7 DOMAIN
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1u81: Delta-17 Human ADP Ribosylation Factor 1 Complexed with GDP
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2j59: CRYSTAL STRUCTURE OF THE ARF1:ARHGAP21-ARFBD COMPLEX
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UpToDate Contents
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English Journal
- Conformational States of ADP Ribosylation Factor 1 Complexed with Different Guanosine Triphosphates As Studied by (31)P NMR Spectroscopy.
- Meierhofer T, Eberhardt M, Spoerner M.SourceUniversity of Regensburg , Institute of Biophysics and Physical Biochemistry, Universitatsstrasse 31, D-93053 Regensburg, Germany.
- Biochemistry.Biochemistry.2011 Jul 26;50(29):6316-27. Epub 2011 Jul 5.
- Guanine nucleotide binding proteins (GNB-proteins) play an essential role in cellular signaling, acting as molecular switches, cycling between the inactive, GDP-bound form and the active, GTP-bound form. It has been shown that conformational equilibria also exist within the active form of GNB-protei
- PMID 21702511
- Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells.
- Wolff NA, Lee WK, Thevenod F.SourceInstitute of Physiology & Pathophysiology, University of Witten/Herdecke, Stockumer Strasse 12, D-58453 Witten, Germany.
- Toxicology letters.Toxicol Lett.2011 Jun 24;203(3):210-8. Epub 2011 Mar 21.
- Cadmium (Cd) is nephrotoxic. Circulating Cd-metallothionein complexes (CdMT) are filtered by the kidney, reabsorbed by proximal tubule cells (PTC) via receptor-mediated endocytosis, and trafficked to lysosomes which results in apoptosis. ADP-ribosylation factors (Arfs) regulate vesicular trafficking
- PMID 21421027
Japanese Journal
- 渡邊 敏明
- ビタミン 84(7), 301-312, 2010-07-25
- … Protein expression in adenosine diphosphate (ADP)-ribosylation factor 2 and α-crystallin may be down-regulated in the mesenchyme of the palatal processes.As for the bioavailability of biotin during gestation, a large amount of biotin was transported to palates and mandibles on dg 12-15 (day of gestation). …
- NAID 110007682285
- The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons
- Suzuki Atsushi,Arikawa Chihiro,Kuwahara Yuji,Itoh Kouichi,Watanabe Masatomo,Watanabe Hiroshi,Suzuki Teruhiko,Funakoshi Yuji,Hasegawa Hiroshi,Kanaho Yasunori,船越 祐司,長谷川 潤,金保 安則
- FEBS letters 584(13), 2801-2806, 2010-07
- … The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions. …
- NAID 120002233499
Related Links
- The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. They are the founding members of a growing family that includes Arl (Arf-like), Arp (Arf-related proteins) ...
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★リンクテーブル★
[★]
- 英
- ADP-ribosylation factor 1、ARF1
- 関
- ADPリボシル化因子1
[★]
- 英
- ADP-ribosylation factor 1
- 関
- ADP-リボシル化因子1
[★]
- 関
- ADP-ribosylation factor 1
[★]
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
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[★]
- 関
- ribosylate