- リボシル化する、リボース化する
English Journal
- Evidence for tankyrases as antineoplastic targets in lung cancer.
- Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ.AbstractBACKGROUND: New pharmacologic targets are urgently needed to treat or prevent lung cancer, the most common cause of cancer death for men and women. This study identified one such target. This is the canonical Wnt signaling pathway, which is deregulated in cancers, including those lacking adenomatous polyposis coli or beta-catenin mutations. Two poly-ADP-ribose polymerase (PARP) enzymes regulate canonical Wnt activity: tankyrase (TNKS) 1 and TNKS2. These enzymes poly-ADP-ribosylate (PARsylate) and destabilize axin, a key component of the beta-catenin phosphorylation complex.
- BMC cancer.BMC Cancer.2013 Apr 28;13(1):211. [Epub ahead of print]
- BACKGROUND: New pharmacologic targets are urgently needed to treat or prevent lung cancer, the most common cause of cancer death for men and women. This study identified one such target. This is the canonical Wnt signaling pathway, which is deregulated in cancers, including those lacking adenomatous
- PMID 23621985
- A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene.
- Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I.SourceFrom the Laboratory of Molecular Biology and.
- The Journal of biological chemistry.J Biol Chem.2013 Apr 26;288(17):12305-12. doi: 10.1074/jbc.M113.461343. Epub 2013 Mar 13.
- HA22 is a recombinant immunotoxin that kills CD22-expressing cells by ADP-ribosylating and inactivating elongation factor-2 (EF2). HA22 is composed of an Fv that binds to CD22 fused to a portion of Pseudomonas exotoxin A. HA22 is very active in drug-resistant hairy cell leukemia but is less active i
- PMID 23486472
- ADP-ribosylation of guanosine by SCO5461 protein secreted from Streptomyces coelicolor.
- Nakano T, Matsushima-Hibiya Y, Yamamoto M, Takahashi-Nakaguchi A, Fukuda H, Ono M, Takamura-Enya T, Kinashi H, Totsuka Y.SourceDivision of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. tnakano@pp.iij4u.or.jp
- Toxicon : official journal of the International Society on Toxinology.Toxicon.2013 Mar 1;63:55-63. doi: 10.1016/j.toxicon.2012.11.019. Epub 2012 Dec 2.
- The Streptomyces coelicolor A3(2) genome encodes a possible secretion protein, SCO5461, that shares a 30% homology with the activity domains of two toxic ADP-ribosyltransferases, pierisins and mosquitocidal toxin. We found ADP-ribosylating activity for the SCO5461 protein product through its co-incu
- PMID 23212047
Japanese Journal
- アクチン特異的ADPリボシル化毒素の構造と機能
- 津下 英明
- 生物物理 43(4), 168-173, 2003-07-25
- モノADPリボシルトランスフェラーゼ群として,細菌のモノADPリボシル化毒素と哺乳類モノADPリボシル化酵素が大きなファミリーを形成している.最近タイプIVの毒素に属するアクチンを標的とするアルギニン特異的なVIP2とla,さらにタイプIIIのRhoをADPリボシル化するC3およびラットART2.2の構造が明らかにされた.本稿ではla-NADH複合体の結晶構造とADPリボシル化の反応機構について解 …
- NAID 110001157629
- Possible Involvement of a Small G-Protein Sensitive to Exoenzyme C3 of Clostridium botulinum in the Regulation of Myofilament Ca^<2+> Sensitivity in β-Escin Skinned Smooth Muscle of Guinea Pig Ileum
- ITAGAKI Mitsue,KOMORI Seiichi,UNNO Toshihiro,SYUTO Bunei,OHASHI Hidenori
- The Japanese journal of pharmacology 67(1), 1-7, 1995-01-01
- … C3 is known to ADP-ribosylate the <I>rho</I> …
- NAID 10005709683
- Cholera Toxin can ADP-Ribosylate Gs as well as Gi in ACTH-Unresponsive Human Adrenocortical Cancer.
- NISHIKAWA TETSUO,YOSHIDA AKIKO,OMURA MASAO,SASANO HIRONOBU,NODA MASATOSHI
- Endocrine Journal 41(5), 593-597, 1994
- … CT ADP-ribosylated 40kDa protein of the plasma membrane of the cancer tissue while CT and PT could ADP-ribosylate 43kDa and 38kDa protein in the adenoma tissue, respectively. … The present experiments demonstrated that CT could ADP-ribosylate Gs which has stimulatory action on adenylate cyclase and also Gi which inhibits adenylate cyclase. …
- NAID 130003549463
Related Links
- Definition of Ribosylate with photos and pictures, translations, sample usage, and additional links for more information. ... ¹ Source: wiktionary.com Ribosylate Pictures Click the following link to bring up a new window with an ...
- ribosylate Definition from Wiktionary, the free dictionary Jump to: navigation, search English [edit] Verb [edit] ribosylate (third-person singular simple present ribosylates, present participle ribosylating, simple past and past participle ribosylated
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★リンクテーブル★
| リンク元 | 「リボシル化」「リボース化」「ribosylation」 |
| 拡張検索 | 「ADP-ribosylate」 |
「リボシル化」
「リボース化」
「ribosylation」
「ADP-ribosylate」
- ADPリボシル化する