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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/06 01:31:12」(JST)

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ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.^[3]

Function

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[4]

The major mechanism of action of Brefeldin A is through inhibition of ARF1.

Interactions

ARF1 has been shown to interact with:

CHRM3,^[5]
COPB1,^[6]^[7]
GGA3,^[8]^[9] and
PLD2.^[10]^[11]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Lee CM, Haun RS, Tsai SC, Moss J, Vaughan M (June 1992). "Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin". J Biol Chem. 267 (13): 9028–34. PMID 1577740.
^ "Entrez Gene: ARF1 ADP-ribosylation factor 1".
^ Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS (September 2003). "ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor". J. Biol. Chem. 278 (36): 33818–30. doi:10.1074/jbc.M305825200. PMID 12799371.
^ Fischer KD, Helms JB, Zhao L, Wieland FT (April 2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles". Methods. 20 (4): 455–64. doi:10.1006/meth.2000.0958. PMID 10720466.
^ Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
^ Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
^ Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/s0092-8674(01)00299-9. PMID 11301005.
^ Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ, Lee JS, Ha SH, Suh PG, Ryu SH (July 2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. 276 (30): 28252–60. doi:10.1074/jbc.M008521200. PMID 11373276.
^ Park JB, Kim JH, Kim Y, Ha SH, Yoo JS, Du G, Frohman MA, Suh PG, Ryu SH (July 2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. 275 (28): 21295–301. doi:10.1074/jbc.M002463200. PMID 10801846.

External links

Human ARF1 genome location and ARF1 gene details page in the UCSC Genome Browser.

English Journal

The mechanism and function of mitogen-activated protein kinase activation by ARF1.

Zhou F1, Dong C1, Davis JE2, Wu WH2, Surrao K2, Wu G3.
Cellular signalling.Cell Signal.2015 Oct;27(10):2035-44. doi: 10.1016/j.cellsig.2015.06.007. Epub 2015 Jul 11.
Mitogen-activated protein kinases (MAPK) can be activated by a number of biochemical pathways through distinct signaling molecules. We have recently revealed a novel function for the Ras-like small GTPase ADP-ribosylation factor 1 (ARF1) in mediating the activation of Raf1-MEK-ERK1/2 pathway by G pr
PMID 26169956

The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells.

Pauloin A1, Adenot P2, Hue-Beauvais C1, Chanat E1.
Cell biology international.Cell Biol Int.2015 Sep 24. doi: 10.1002/cbin.10547. [Epub ahead of print]
The cytosolic lipid droplets (cLDs) store excess intracellular lipids, and perilipin-2 is believed to protect cLDs from degradation. Here, we investigated the role of the small G-protein Arf1 and the proteasome in the fates of perilipin-2 and cLDs. In oleate-loaded cells, upon brefeldin A (BFA) trea
PMID 26399370

Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines.

Toda T1, Watanabe M2, Kawato J1, Kadin ME3, Higashihara M2, Kunisada T4, Umezawa K5, Horie R2.
British journal of haematology.Br J Haematol.2015 Sep;170(6):837-46. doi: 10.1111/bjh.13508. Epub 2015 Jun 24.
To obtain further insights into the biological differences of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ ALCL) and classical Hodgkin lymphoma (HL), we screened microbial culture filtrates to search for compounds that would exert a significantly greater effect on the via
PMID 26105086

Japanese Journal

10. オーキシン応答転写因子ARF1による無性芽発生の制御(口頭発表,植物化学調節学会第49回大会)

神埜勝,加藤大貴,武田真由子,石崎公庸,西浜竜一,河内孝之
植物化学調節学会研究発表記録集 49(Supplement), 28, 2014-10-01
NAID 110009865099

Traffic jam on the cellular secretory pathway generated by a replication protein from a plant RNA virus

Hyodo Kiwamu,Kaido Masanori,Okuno Tetsuro
Plant Signaling & Behavior 9(3), 2014-04-08
… Previously, we showed that a plant RNA virus, Red clover necrotic mosaic virus (RCNMV), hijacked Arf1 and Sar1, which are small GTPases that regulate the biogenesis of COPI and COPII vesicles, respectively, for viral RNA replication. …
NAID 120005439155

BEX1/ARF1A1C is Required for BFA-Sensitive Recycling of PIN Auxin Transporters and Auxin-Mediated Development in Arabidopsis (Special Focus Issue : Plant Endomembranes)

Tanaka Hirokazu,Nodzynski Tomasz,Kitakura Saeko [他]
Plant and cell physiology 55(4), 737-749, 2014-04
NAID 40020302027

Related Pictures

ARF1 - Wikipedia, the free encyclopedia Recruitment of Coatomer to Membranes: Cell IJMS | Free Full-Text | ARF1 and SAR1 Figure 6 - Model of clathrin–AP-1-coated QAV250 G10 ARF1 Kit

★リンクテーブル★

リンク元	「ADP-リボシル化因子1」「ADP-ribosylation factor 1」
関連記事	「AR」「ARF」

「ADP-リボシル化因子1」

ARF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HUR, 1RE0, 1U81, 3O47, 4HMY, 1R8Q, 1RRG, 1RRF
Identifiers
Aliases	ARF1
External IDs	MGI: 99431 HomoloGene: 133930 GeneCards: ARF1
Gene ontology
Molecular function	• phospholipase D activator activity; • nucleotide binding; • GTP binding; • magnesium ion binding; • signal transducer activity, downstream of receptor; • GTPase activity; • GDP binding; • protein binding; • RNA binding;
Cellular component	• extracellular exosome; • late endosome; • cytoplasm; • synapse; • trans-Golgi network; • Golgi apparatus; • cell junction; • endomembrane system; • peroxisomal membrane; • cell leading edge; • neuron projection; • postsynaptic density; • postsynaptic membrane; • membrane; • focal adhesion; • intracellular; • perinuclear region of cytoplasm; • sarcomere; • COPI-coated vesicle; • cytosol; • Golgi membrane; • plasma membrane;
Biological process	• positive regulation of endocytosis; • positive regulation of protein secretion; • very-low-density lipoprotein particle assembly; • regulation of defense response to virus by virus; • positive regulation of calcium ion-dependent exocytosis; • regulation of receptor internalization; • synaptic vesicle budding; • small GTPase mediated signal transduction; • cellular copper ion homeostasis; • long term synaptic depression; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • Golgi to transport vesicle transport; • post-Golgi vesicle-mediated transport; • actin filament organization; • lysosomal membrane organization; • positive regulation of ER to Golgi vesicle-mediated transport; • transport; • dendritic spine organization; • regulation of phospholipid metabolic process; • regulation of Arp2/3 complex-mediated actin nucleation; • positive regulation of late endosome to lysosome transport; • protein transport; • phosphatidylinositol biosynthetic process; • positive regulation of sodium ion transmembrane transport; • vesicle-mediated transport; • positive regulation of catalytic activity; • positive regulation of dendritic spine development;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	375
	11840
	ENSG00000143761
	ENSMUSG00000048076
	P84077
	P84078
	NM_001658; NM_001024226; NM_001024227; NM_001024228
	NM_001130408; NM_007476
	NP_001019397; NP_001019398; NP_001019399; NP_001649
	NP_001123880.1; NP_031502.1; NP_001123880; NP_031502
	Wikidata
View/Edit Human	View/Edit Mouse