- 同
- HM GCoA
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- being or containing a hydroxyl group
PrepTutorEJDIC
- carbonの化学記号
- cobaltの化学記号
UpToDate Contents
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English Journal
- Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.
- Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP.SourceDivision of Interdisciplinary Medicine, Beth Israel Deaconess Medical Center, Department of Medicine, Boston, Massachusetts 02215, USA.
- Journal of cellular physiology.J Cell Physiol.2012 Apr;227(4):1709-20. doi: 10.1002/jcp.22895.
- ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. A definitive role for ACL in tumorigenesis has emerged from ACL RNAi and chemical inhibitor studies, showing that ACL inhibition limits tumor cell proliferation and survival and induces differentiat
- PMID 21688263
- Influence of multiple cysteines on human 3-hydroxy-3-methylglutaryl-CoA lyase activity and formation of inter-subunit adducts.
- Montgomery C, Miziorko HM.SourceDivision of Molecular Biology and Biochemistry, University of Missouri, Kansas City, MO 64110, United States.
- Archives of biochemistry and biophysics.Arch Biochem Biophys.2011 Jul;511(1-2):48-55. Epub 2011 Apr 13.
- Human 3-hydroxy-3-methylglutaryl-CoA lyase catalyzes formation of acetyl-CoA and acetoacetate in a reaction that requires divalent cation and is stimulated by sulfhydryl protective reagents. The enzyme is a homodimer and inter-subunit adducts form in the absence of reducing agents or upon treatment
- PMID 21514269
Japanese Journal
- Effect of Polyphenols on 3-Hydroxy-3-methylglutaryl-Coenzyme A Lyase Activity in Human Hepatoma HepG2 Cell Extracts
- Nakagawa Saori,Kojima Yuko,Sekino Koichi [他],Yamato Susumu
- Biological and Pharmaceutical Bulletin 36(12), 1902-1906, 2013
- … Excess acetyl-coenzyme A (CoA) is generated from fatty acids by β-oxidation and is used for the formation of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) and subsequently for acetoacetate. … High levels of secreted ketone bodies (acetoacetate and 3β-hydroxybutyrate) lower the pH of blood and urine, resulting in ketoacidosis. …
- NAID 130003382056
- 生後3か月で発症した3-ヒドロキシ-3-メチルグルタリルCoAリアーゼ欠損症の1例
- 高橋 朋子,関口 隆憲,岡村 和美 [他],阪田 美穂,清水 真樹,須賀 健一,幸山 洋子,大原 克明,小林 弘典,依藤 亨
- 日本小児科学会雑誌 112(8), 1249-1254, 2008-08-01
- NAID 10024462485
- Separation and identification of plasma short-chain acylcarnitine isomers by HPLC/MS/MS for the differential diagnosis of fatty acid oxidation defects and organic acidemias
- FERRER Isaac,RUIZ-SALA Pedro,VICENTE Yolanda,MERINERO Begona,PEREZ-CERDA Celia,UGARTE Magdalena
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 860(1), 121-126, 2007-12-01
- NAID 10027467081
Related Links
- 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (also known as HMG-CoA lyase deficiency) is an uncommon inherited disorder in which the body cannot process a particular protein building block (amino acid) called ...
- 3-hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) plays an essential role in breaking down dietary proteins and fats for energy. Specifically, the enzyme is required for ketogenesis in the liver, and is also responsible for ...
★リンクテーブル★
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ヒドロキシ、ハイドロキシ、水酸化
- 関
- hydroxylation
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補酵素A coenzyme A CoA
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ヒドロ、ハイドロ