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1. ガンマヒドロキシブチレート（GHB）中毒gamma hydroxybutyrate ghb intoxication [show details]
… acute GHB toxicity is heightened by several factors, many of which may be unknown to the user : the drug steep dose-response curve (narrow safety margin), the abrupt onset of effects, the variability and unpredictability …
2. 成人における抗癌剤の投与dosing of anticancer agents in adults [show details]
… response or treatment failure, adverse events, suspected drug interactions, or nonadherence to therapy . Most anticancer drugs have a steep dose response relationship and a narrow therapeutic index …
3. 成人における腹腔鏡下手術および腹部ロボット手術のための麻酔anesthesia for laparoscopic and abdominal robotic surgery in adults [show details]
…pressure ≤15 mmHg to minimize physiologic effects. For laparoscopic prostatectomy, which is performed in steep Trendelenburg position, the European Association for Endoscopic Surgery recommends IAP below 12 mmHg … nonsteroidal antiinflammatory drugs (NSAIDs) or cyclooxygenase₂ (COX₂)-specific inhibitors,…
4. 子宮膣上部切断術後の子宮頸部切除術trachelectomy following supracervical hysterectomy [show details]
…endometriosis, pelvic mass, or adhesions). The open approach is reserved for women who may not tolerate the steep Trendelenburg position required for laparoscopic or robot-assisted procedures, such as those with …
5. 無気肺：成人における種類および病因atelectasis types and pathogenesis in adults [show details]
…occlusion of a bronchus, intraalveolar oxygen distal to the obstruction is rapidly reabsorbed along a steep pressure gradient into deoxygenated mixed venous blood. The pressure gradient forcing nitrogen into…