創面

WordNet

on the surface; "surface materials of the moon"
the outer boundary of an artifact or a material layer constituting or resembling such a boundary; "there is a special cleaner for these surfaces"; "the cloth had a pattern of red dots on a white surface"
the outermost level of the land or sea; "earthquakes originate far below the surface"; "three quarters of the Earths surface is covered by water" (同)Earth''s surface
a superficial aspect as opposed to the real nature of something; "it was not what it appeared to be on the surface"
the extended two-dimensional outer boundary of a three-dimensional object; "they skimmed over the surface of the water"; "a brush small enough to clean every dental surface"; "the sun has no distinct surface"
come to the surface (同)come_up, rise up, rise
put in a coil
an injury to living tissue (especially an injury involving a cut or break in the skin) (同)lesion
the act of inflicting a wound (同)wounding
a casualty to military personnel resulting from combat (同)injury, combat injury
a figurative injury (to your feelings or pride); "he feared that mentioning it might reopen the wound"; "deep in her breast lives the silent wound"; "The right reader of a good poem can tell the moment it strikes him that he has taken an immortal wound--t
people who are wounded; "they had to leave the wounded where they fell" (同)maimed
emerging to the surface and becoming apparent

PrepTutorEJDIC

(物の)表面,外面;水面 / 《比喩的に》『うわべ』,見かけ / 『表面(水面)の,』表面(水面)に関する / 《比喩的に》『うわべだけの,』見かけだけの / 陸(水)上輸送の / (沈んでいたものが)表面に浮上する;《話》《おどけて》(寝ていた人が)起きる / (…で)…‘に'表面をつける,〈道路〉‘を'舗装する《+名+with+名》
windの過去・過去分詞
(身体の)『傷』,負傷 / (感情・自尊心などに対する)『痛手』,傷《+to+『名』》 / …‘を'『負傷させる』 / 〈感情など〉‘を'傷つける,〈人〉‘の'感情などを傷つける
(特に戦争で)負傷した;(感情などが)傷つけられた

UpToDate Contents

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1. 創傷マネージメントの基本原則 basic principles of wound management
2. 胸骨創傷合併症の外科的マネージメント surgical management of sternal wound complications
3. 開腹術の合併症 complications of abdominal surgical incisions
4. 陰圧創傷閉鎖法 negative pressure wound therapy
5. 小さな創傷部の処置および洗浄 minor wound preparation and irrigation

English Journal

Tunnelized preauricular transposition flap for reconstruction of auricular defect.

Pereira N1, Brinca A, Vieira R, Figueiredo A.Author information 1Department of Dermatology, Coimbra University Hospital , Coimbra , Portugal.AbstractBACKGROUND: Reconstruction of surgical defects of the auricular region is a complex challenge, especially when they are localized in the anterior surface, due to the convexities and concavities of this region.
The Journal of dermatological treatment.J Dermatolog Treat.2014 Oct;25(5):441-3. doi: 10.3109/09546634.2012.713457. Epub 2012 Sep 19.
BACKGROUND: Reconstruction of surgical defects of the auricular region is a complex challenge, especially when they are localized in the anterior surface, due to the convexities and concavities of this region.PATIENTS AND RESULTS: The authors present the case of an 89-year-old woman who underwent ra
PMID 22812493

The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid-octadecylamine conjugate.

She Z1, Zhang T1, Wang X1, Li X1, Song Y1, Cheng X1, Huang Z1, Deng Y2.Author information 1College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China.2College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China. Electronic address: pharmdeng@gmail.com.AbstractBased on the knowledge that sialic acid is a critical element for tumor development and its receptors are highly expressed on the tumor-associated macrophages (TAMs) which play important roles in the growth and metastasis of tumors, we synthesized a sialic acid-octadecylamine conjugate (SA-ODA) and anchored it on the surface of pixantrone (Pix)-loaded liposomes, to achieve an improved anticancer effect. Four Pix formulations (Pix-S, Pix-CL, Pix-PL and Pix-SAL represent solution, conventional liposome, stealth liposome, and SA-ODA modified liposome, respectively) were developed, and various parameters, including drug loading, stability, in vitro release, cytotoxicity and pharmacokinetics, were evaluated. The tumor growth inhibition and toxicity studies were performed in S180-bearing Kunming mice. Pix-S exhibited a strong toxicity to the immune system, accelerated the growth of tumors and reduced the lifespan of mice. In contrast, Pix-SAL displayed the strongest anticancer and life-prolonging effects among all of the formulations in this study. More importantly, injection of Pix-SAL induced a phenomenon whereby the cancerous tissues were "shed" from mice, after which the wound healed. We speculate that this special efficacy may be partly due to the killing of TAMs by Pix-SAL. This study suggests that SA-ODA modified liposomes may serve as an effective intravenous delivery vehicle for Pix.
Biomaterials.Biomaterials.2014 Jun;35(19):5216-25. doi: 10.1016/j.biomaterials.2014.03.022. Epub 2014 Apr 2.
Based on the knowledge that sialic acid is a critical element for tumor development and its receptors are highly expressed on the tumor-associated macrophages (TAMs) which play important roles in the growth and metastasis of tumors, we synthesized a sialic acid-octadecylamine conjugate (SA-ODA) and
PMID 24703714

The regulatory peptide pidotimod facilitates M2 macrophage polarization and its function.

Hu S1, Fu X, Fu A, Du W, Ji J, Li W.Author information 1Key Laboratory of Animal Molecular Nutrition of Education of Ministry, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, China.AbstractPidotimod is a synthetic dipeptide with biological and immunological activity in innate immune responses. It has been reported that pidotimod could promote functional maturation of dendritic cells, but little is known about the regulation of macrophages. Recent studies have demonstrated that M1 or M2 polarized macrophages are of great importance for responses to microorganism infection or host mediators. The aim of this study was to determine the effectiveness of pidotimod on mouse bone marrow-derived macrophage polarization and its function. The results showed that pidotimod had no influence on M1-polarized macrophage. While interestingly, a significant increase of M2 marker gene expression (Arg1, Fizz1, Ym1, MR) was observed (p < 0.01) in IL-4-induced M2 macrophage treated with pidotimod. In addition, cell surface expression of mannose receptor was dramatically enhanced using fluorescence activated cell sorter (FACS) analysis. Furthermore, the function of M2 macrophage was also determinated. The results showed that the supernatant of pidotimod-treated M2 macrophage could increase the migration (p < 0.05) and enhance the wound closure rate (p < 0.05) of MLE-12 cells. Collectively, it could be concluded that pidotimod significantly facilitated IL-4-induced M2 macrophage polarization and improves its function.
Amino acids.Amino Acids.2014 May;46(5):1177-85. doi: 10.1007/s00726-014-1676-4. Epub 2014 Jan 31.
Pidotimod is a synthetic dipeptide with biological and immunological activity in innate immune responses. It has been reported that pidotimod could promote functional maturation of dendritic cells, but little is known about the regulation of macrophages. Recent studies have demonstrated that M1 or M
PMID 24481486

Japanese Journal

Combination of root surface modification with BMP-2 and collagen hydrogel scaffold implantation for periodontal healing in beagle dogs

Kato Akihito,Miyaji Hirofumi,Ishizuka Ryosuke,Tokunaga Keisuke,Inoue Kana,Kosen Yuta,Yokoyama Hiroyuki,Sugaya Tsutomu,Tanaka Saori,Sakagami Ryuji,Kawanami Masamitsu
The Open Dentistry Journal 9, 52-59, 2015-01-30
… Objective: Biomodification of the root surface plays a major role in periodontal wound healing. … We examined the effects of BMP modification in conjunction withcollagen hydrogel scaffold implantation on periodontal wound healing in dogs. … Conclusion: The combination methodusing root surface modification with BMP and collagen hydrogel scaffold implantation facilitated the reestablishment ofperiodontal attachment. …
NAID 120005572431

Management of Lacerated and Swollen Tongue after Convulsive Seizure with a Mouth Protector: Interprofessional Collaboration Including Dentists in Intensive Care

Yamanaka Reiko,Soga Yoshihiko,Moriya Yoshie,Okui Akemi,Takeuchi Tetsuo,Sato Kenji,Morimatsu Hiroshi,Morita Manabu
Acta Medica Okayama 68(6), 375-378, 2014-12
… The tongue showed severe swelling, and the right ventral surface had been lacerated by his isolated and pointed right lower canine. … By raising the patientʼs bite, the completed mouth protector prevented the isolated tooth from contacting the tongue and protected the lacerated wound. …
NAID 120005525316

ヘパリン結合性上皮成長因子様成長因子の刺激誘発による切断・放出への活性酸素種の関与

馬田敏幸
産業医科大学雑誌 36(2), 105-114, 2014-06-01
ヘパリン結合性上皮成長因子様成長因子(HB-EGF)は,創傷治癒,動脈硬化および癌増殖など多くの生理的,病理的過程に関与している成長因子である.HB-EGFは膜型として合成され,細胞表面でプロテアーゼにより切断・放出(エクトドメインシェディング:シェディング)されて増殖活性を獲得する.この研究では,HB-EGFをサルの腎細胞に高発現させたVero-H細胞を使って,HB-EGFのシェディングヘの活性 …
NAID 110009823329