- 関
- vesicular trafficking
WordNet
- move something or somebody around; usually over long distances
- an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
- move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
- transport commercially (同)send, ship
- of or relating to or involving vesicles; "normal vesicular breathing"
PrepTutorEJDIC
- (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
- 小嚢の小胞の,小嚢(小胞)状の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/19 21:12:09」(JST)
[Wiki en表示]
A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of specific molecules (transporter substrates) across a vesicular membrane.[1] As a result, vesicular transporters govern the concentration of molecules within a vesicle.
Contents
- 1 Types
- 2 Pathways
- 3 See also
- 4 References
Types
Examples include:
- Archain
- ARFs
- Clathrin
- Caveolin
- Dynamin and related proteins, such as the EHD protein family
- Rab proteins
- SNAREs
- Sorting nexins
- Synaptotagmin
- TRAPP complex
Pathways
There are multiple pathways, each using its own coat and GTPase.[2]
- COP 1 (Cytosolic coat protein complex ) : retrograde transport ; Golgi ----> Endoplasmic reticulum
- COP 2 (Cytosolic coat protein complex ) : anterograde transport ; RER -----> cis-Golgi
- Clathrin : trans-Golgi ----> Lysosomes, Plasma membrane ----> Endosomes (receptor-mediated endocytosis)
See also
- Membrane transport protein
- Wikipedia:MeSH_D12.776#MeSH_D12.776.543.990_---_vesicular_transport_proteins
References
- ^ Vesicular Transport Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Yasushi Sako (1 October 2010). Cell Signaling Reactions: Single-Molecular Kinetic Analysis. Springer. pp. 168–. ISBN 978-90-481-9863-4. Retrieved 15 December 2010.
UpToDate Contents
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English Journal
- Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
- Koldamova R1, Schug J2, Lefterova M3, Cronican AA4, Fitz NF4, Davenport FA4, Carter A4, Castranio EL4, Lefterov I5.Author information 1Department of Environmental & Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: radak@pitt.edu.2Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA; Functional Genomics Core, Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.3Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.4Department of Environmental & Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.5Department of Environmental & Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: iliyal@pitt.edu.AbstractEarly growth response gene 1 (Egr1) is a member of the immediate early gene (IEG) family of transcription factors and plays a role in memory formation. To identify EGR1 target genes in brain of Alzheimer's disease (AD) model mice - APP23, we applied chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq). Functional annotation of genes associated with EGR1 binding revealed a set of related networks including synaptic vesicle transport, clathrin-mediated endocytosis (CME), intracellular membrane fusion and transmission of signals elicited by Ca(2+) influx. EGR1 binding is associated with significant enrichment of activating chromatin marks and appears enriched near genes that are up-regulated in the brains of APP23 mice. Among the putative EGR1 targets identified and validated in this study are genes related to synaptic plasticity and transport of proteins, such as Arc, Grin1, Syn2, Vamp2 and Stx6, and genes implicated in AD such as Picalm, Psen2 and App. We also demonstrate a potential regulatory link between EGR1 and its newly identified targets in vivo, since conditions that up-regulate Egr1 levels in brain, such as a spatial memory test, also lead to increased expression of the targets. On the other hand, protein levels of EGR1 and ARC, SYN2, STX6 and PICALM are significantly lower in the brain of adult APP mice than in age-matched wild type animals. The results of this study suggest that EGR1 regulates the expression of genes involved in CME, vesicular transport and synaptic transmission that may be critical for AD pathogenesis.
- Neurobiology of disease.Neurobiol Dis.2014 Mar;63:107-14. doi: 10.1016/j.nbd.2013.11.005. Epub 2013 Nov 20.
- Early growth response gene 1 (Egr1) is a member of the immediate early gene (IEG) family of transcription factors and plays a role in memory formation. To identify EGR1 target genes in brain of Alzheimer's disease (AD) model mice - APP23, we applied chromatin immunoprecipitation (ChIP) followed by h
- PMID 24269917
- Function and dynamics of slam in furrow formation in early Drosophila embryo.
- Acharya S1, Laupsien P1, Wenzl C1, Yan S1, Großhans J2.Author information 1Institut für Entwicklungsbiochemie, Universitätsmedizin, Universität Göttingen, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany.2Institut für Entwicklungsbiochemie, Universitätsmedizin, Universität Göttingen, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany. Electronic address: jgrossh@gwdg.de.AbstractThe Drosophila embryo undergoes a developmental transition in the blastoderm stage switching from syncytial to cellular development. The cleavage furrow, which encloses nuclei into cells, is a prominent morphological feature of this transition. It is not clear how the pattern of the furrow array is defined and how zygotic genes trigger the formation and invagination of interphase furrows. A key to these questions is provided by the gene slam, which has been previously implicated in controlling furrow invagination. Here we investigate the null phenotype of slam, the dynamics of Slam protein, and its control by the recycling endosome. We find that slam is essential for furrow invagination during cellularisation and together with nullo, for specification of the furrow. During cellularisation, Slam marks first the furrow, which is derived from the metaphase furrow of the previous mitosis. Slightly later, Slam accumulates at new furrows between daughter cells early in interphase. Slam is stably associated with the furrow canal except for the onset of cellularisation as revealed by FRAP experiments. Restriction of Slam to the furrow canal and Slam mobility during cellularisation is controlled by the recycling endosome and centrosomes. We propose a three step model. The retracting metaphase furrow leaves an initial mark. This mark and the border between corresponding daughter nuclei are refined by vesicular transport away from pericentrosomal recycling endosome towards the margins of the somatic buds. Following the onset of zygotic gene expression, Slam and Nullo together stabilise this mark and Slam triggers invagination of the cleavage furrow.
- Developmental biology.Dev Biol.2014 Feb 15;386(2):371-84. doi: 10.1016/j.ydbio.2013.12.022. Epub 2013 Dec 22.
- The Drosophila embryo undergoes a developmental transition in the blastoderm stage switching from syncytial to cellular development. The cleavage furrow, which encloses nuclei into cells, is a prominent morphological feature of this transition. It is not clear how the pattern of the furrow array is
- PMID 24368071
- Membranes and mammalian glycolipid transferring proteins.
- Tuuf J1, Mattjus P2.Author information 1Biochemistry, Department of Biosciences, Åbo Akademi University, Turku, Finland.2Biochemistry, Department of Biosciences, Åbo Akademi University, Turku, Finland. Electronic address: pmattjus@abo.fi.AbstractGlycolipids are synthesized in and on various organelles throughout the cell. Their trafficking inside the cell is complex and involves both vesicular and protein-mediated machineries. Most important for the bulk lipid transport is the vesicular system, however, lipids moved by transfer proteins are also becoming more characterized. Here we review the latest advances in the glycolipid transfer protein (GLTP) and the phosphoinositol 4-phosphate adaptor protein-2 (FAPP2) field, from a membrane point of view.
- Chemistry and physics of lipids.Chem Phys Lipids.2014 Feb;178:27-37. doi: 10.1016/j.chemphyslip.2013.10.013. Epub 2013 Nov 9.
- Glycolipids are synthesized in and on various organelles throughout the cell. Their trafficking inside the cell is complex and involves both vesicular and protein-mediated machineries. Most important for the bulk lipid transport is the vesicular system, however, lipids moved by transfer proteins are
- PMID 24220498
Japanese Journal
- 細胞膜を介したトランスポーター介在性輸送と小胞輸送によるその制御 (特集 細胞内小胞輸送)
- In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine–Serine–Cysteine Transporter 2
- , , ,
- Biological and Pharmaceutical Bulletin 38(6), 901-908, 2015
- … TR-rPCT1 cells express the mRNAs of vesicular L-Glu transporter 1 (VGLUT1), indicating that L-Glu in the cytoplasm is taken up into VGLUT1-expressing vesicles of retinal pericytes. … Regarding the L-Gln uptake by TR-rPCT1 cells, the inhibitory effect of ASCT substrates on the [3H]L-Gln uptake was stronger than that of substrates of other neutral amino acid transport systems. …
- NAID 130005072672
- 細胞内小胞輸送でタンパク質を目的地へ:小胞体から始まる小胞輸送
- 佐藤 健
- 膜 40(1), 2-8, 2015
- … The secretory and endocytic pathways in eukaryotic cells act as major routes for biomolecule transport out of andinto the cell. … Transport from one organelle of these pathways to another is mediated by vesicular carriers, which aregenerated by coat protein complexes regulated by the small GTPases. …
- NAID 130005069460
Related Links
- Vesicular transport is an active process in which materials move into or out of the cell enclosed as vesicles. ... A vesicular texture is one where there are small voids within the igneous rock. These tend to form in extrusive igneous ...
- ABC Transporter Vesiclesは、ABC Transporter Membranes を膜小胞輸送アッセイ (Vesicular transport assay) 用に調製した製品です。 ABC Transporter Vesicles では、膜画分の一部が反転膜小胞 (inside-out vesicles) の構造をとって ...
Related Pictures
★リンクテーブル★
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- 英
- vesicular transport、vesicular trafficking
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- 関
- vesicular transport
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- 関
- bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation
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- 関
- vesicle