oncogene protein v-Cbl

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the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
the 22nd letter of the Roman alphabet (同)v

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carbonの化学記号
vanadium の化学記号
verb / verso / 《話》very / velocity / volt[s] / volume / vide
columbiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/01 12:42:37」(JST)

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Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.^[1]

Discovery

In 1989 a virally encoded portion of the chromosomal mouse Cbl gene was the first member of the Cbl family to be discovered^[2] and was named v-Cbl to distinguish it from normal mouse c-Cbl. The virus used in the experiment was a retrovirus known as Cas-Br-M, and was found to have excised approximately a third of the original c-Cbl gene from mice it was injected into. Sequencing revealed that the portion carried by the retrovirus encoded a tyrosine kinase binding domain, and that this was the oncogenic form as retroviruses carrying full-length c-Cbl did not induce tumour formation. The resultant transformed retrovirus was found to consistently induce a type of pre-B lymphoma, known as Casitas B-lineage lymphoma, in infected mice.

Structure

Full length c-Cbl has been found to consist of several regions encoding for functionally distinct protein domains:

N-terminal tyrosine kinase binding domain (TKB domain): determines the protein which it can bind to
RING finger domain motif: recruits enzymes involved in ubiquitination
Proline-rich region: the site of interaction between Cbl and cytosolic proteins involved in Cbl's adaptor functions
C-terminal ubiquitin-associated domain (UBA domain): the site of ubiquitin binding

This domain structure and the tyrosine and serine-rich content of the protein product is typical of an "adaptor molecule" used in cell signalling pathways.^[3]

Homologues

Three mammalian homologues have been characterized, which all differ in their ability to function as adaptor proteins due to the differing lengths of their C-terminal UBA domains:

c-Cbl: ubiquitously expressed, 906 and 913 amino acids in length in humans and mice respectively
Cbl-b: ubiquitously expressed, 982 amino acids long in length.
Cbl-c: lacks the UBA domain and is therefore only 474 amino acids in length. It is primarily expressed in epithelial cells however its function is poorly understood.

Interestingly, both c-Cbl and Cbl-b have orthologues in D. melanogaster (D-Cbl) and C. elegans (Sli-1), hinting at a long evolutionary path for these proteins.^[3]

Function

Ubiquitin ligase

Ubiquitination is the process of chemically attaching ubiquitin monomers to a protein, thereby targeting it for degradation. As this is a multi-step process, several different enzymes are involved, the final one being a member of the E3 family of ligases. Cbl functions as an E3 ligase, and therefore is able to catalyse the formation of a covalent bond between ubiquitin and Cbl's protein substrate - typically a receptor tyrosine kinase. The RING-finger domain mediates this transfer, however like other E3 ligases of the RING type no intermediate covalent bond is formed between ubiquitin and the RING-finger domain. The stepwise attachment of ubiquitin to the substrate receptor tyrosine kinase can lead to its removal from the plasma membrane and subsequent trafficking to the lysosome for degradation.

Interactions

Cbl gene has been shown to interact with:

Abl gene,^[4]^[5]
ARHGEF7,^[6]
C-Met,^[7]^[8]
CD2AP,^[9]^[10]^[11]
CSF1R.^[12]
CRK,^[13]^[14]
CRKL,^[15]^[16]^[17]^[18]^[19]^[20]^[21]^[22]
EGFR,^[7]<^[23]^[24]
FRS2,^[25]
FYN,^[19]^[26]
Grb2,^[7]^[13]^[14]^[15]^[25]^[27]^[28]^[29]^[30]^[31]^[32]^[33]^[34]
HCK,^[35]^[36]
IGF1R,^[37]
LCP2;,^[15]^[38]
NCK1,^[4]^[15]
PDGFRA,^[39]
PIK3R1,^[13]^[40]^[41]
PIK3R2,^[42]^[43]
PLCG1,^[44]^[45]
PTK2B,^[9]^[46]
PTPN11,^[47]
SH2B2,^[7]^[48]
SH3KBP1^[8]^[49]^[50]^[51]^[52]
SHC1,^[13]^[27]
SLA2,^[53]
SORBS1,^[9]^[54]
SORBS2,^[5]^[9]
SPRY2,^[7]^[55]^[56]
Syk,^[57]^[58]^[59]
UBE2L3,^[55]^[60]^[61]
VAV1,^[58]^[62]
YWHAB,^[31]
YWHAQ,^[63]^[64] and
ZAP-70,^[65]^[66]

References

^ Naramura M, Nadeau S, Mohapatra B, Ahmad G, Mukhopadhyay C, Sattler M et al. (2011). "Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders". Oncotarget 2 (3): 245–50. PMC 3134300. PMID 21422499.
^ Langdon WY, Hartley JW, Klinken SP, Ruscetti SK, Morse HC (1989). "v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1168–72. doi:10.1073/pnas.86.4.1168. PMC 286647. PMID 2784003.
^ ^a ^b Schmidt MH, Dikic I (2005). "The Cbl interactome and its functions". Nat. Rev. Mol. Cell Biol. 6 (12): 907–18. doi:10.1038/nrm1762. PMID 16227975.
^ ^a ^b Miyoshi-Akiyama T, Aleman LM, Smith JM, Adler CE, Mayer BJ (July 2001). "Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor". Oncogene 20 (30): 4058–69. doi:10.1038/sj.onc.1204528. PMID 11494134.
^ ^a ^b Soubeyran P, Barac A, Szymkiewicz I, Dikic I (February 2003). "Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl". Biochem. J. 370 (Pt 1): 29–34. doi:10.1042/BJ20021539. PMC 1223168. PMID 12475393.
^ Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA (August 2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): 119–23. doi:10.1016/S0014-5793(03)00853-6. PMID 12935897.
^ ^a ^b ^c ^d ^e Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (March 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.
^ ^a ^b Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
^ ^a ^b ^c ^d Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
^ Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H (February 2001). "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction". J. Biol. Chem. 276 (7): 4957–63. doi:10.1074/jbc.M005784200. PMID 11067845.
^ Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C et al. (February 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.
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^ Tvorogov D, Carpenter G (July 2002). "EGF-dependent association of phospholipase C-gamma1 with c-Cbl". Exp. Cell Res. 277 (1): 86–94. doi:10.1006/excr.2002.5545. PMID 12061819.
^ Graham LJ, Stoica BA, Shapiro M, DeBell KE, Rellahan B, Laborda J et al. (August 1998). "Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochem. Biophys. Res. Commun. 249 (2): 537–41. doi:10.1006/bbrc.1998.9177. PMID 9712732.
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External links

Quips article describing CBL function at PDBe
OMIM enteries on NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA and CBL

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PMID 25952305

Deltex1 promotes protein kinase Cθ degradation and sustains Casitas B-lineage lymphoma expression.

Hsu TS1, Hsiao HW2, Wu PJ3, Liu WH2, Lai MZ4.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Aug 15;193(4):1672-80. doi: 10.4049/jimmunol.1301416. Epub 2014 Jul 7.
PMID 25000980

Japanese Journal

Exploiting Versions for Transactional Cache Consistency(Database)

IEICE transactions on information and systems E88-D(6), 1191-1198, 2005-06-01
NAID 110003214299

The sequences of the human and mouse c-cbl protooncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif

Oncogene 6, 653-657, 1991
NAID 80005875622

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

Proc Natl Acad Sci USA 86, 1168-1172, 1989
NAID 80004502672

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★リンクテーブル★

拡張検索	「癌遺伝子産物v-Cbl」
関連記事	「C」「V」「vs」

「癌遺伝子産物v-Cbl」

Cbl proto-oncogene, E3 ubiquitin protein ligase
	PDB rendering based on 1b47.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1B47, 1FBV, 1YVH, 2CBL, 2JUJ, 2K4D, 2OO9, 2Y1M, 2Y1N, 3BUM, 3BUN, 3BUO, 3BUW, 3BUX, 3OB1, 3OB2, 3PLF, 4A49, 4A4B, 4A4C, 4GPL
Identifiers
Symbols	CBL ; C-CBL; CBL2; FRA11B; NSLL; RNF55
External IDs	OMIM: 165360 MGI: 88279 HomoloGene: 3802 GeneCards: CBL Gene
Gene ontology
Molecular function	• phosphotyrosine binding; • sequence-specific DNA binding transcription factor activity; • ubiquitin-protein transferase activity; • signal transducer activity; • calcium ion binding; • protein binding; • zinc ion binding; • ligase activity; • SH3 domain binding; • ephrin receptor binding; • ubiquitin protein ligase activity;
Cellular component	• nucleus; • cytoplasm; • cytosol; • plasma membrane; • flotillin complex;
Biological process	• regulation of transcription, DNA-templated; • cell surface receptor signaling pathway; • epidermal growth factor receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • positive regulation of phosphatidylinositol 3-kinase signaling; • protein ubiquitination; • negative regulation of epidermal growth factor receptor signaling pathway; • negative regulation of apoptotic process; • positive regulation of receptor-mediated endocytosis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: oncogene protein v-Cbl

「C」

　　[★]

炭素 carbon
シトシン cytosine
システイン cysteine
シチジン
セルシウス度摂氏 degrees Celsius degree C
産婦人科領域で「子宮外頚子宮外頚部 exocervix」を表現するための略語

「V」

　　[★]

「vs」

　　[★]

対

関: pair、paired、pairwise、versus

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[langdon-2] Langdon WY, Hartley JW, Klinken SP, Ruscetti SK, Morse HC (1989). "v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1168–72. doi:10.1073/pnas.86.4.1168. PMC 286647. PMID 2784003.

[mirko-3] Schmidt MH, Dikic I (2005). "The Cbl interactome and its functions". Nat. Rev. Mol. Cell Biol. 6 (12): 907–18. doi:10.1038/nrm1762. PMID 16227975.

[pmid11494134-4] Miyoshi-Akiyama T, Aleman LM, Smith JM, Adler CE, Mayer BJ (July 2001). "Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor". Oncogene 20 (30): 4058–69. doi:10.1038/sj.onc.1204528. PMID 11494134.

[pmid12475393-5] Soubeyran P, Barac A, Szymkiewicz I, Dikic I (February 2003). "Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl". Biochem. J. 370 (Pt 1): 29–34. doi:10.1042/BJ20021539. PMC 1223168. PMID 12475393.

[pmid12935897-6] Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA (August 2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): 119–23. doi:10.1016/S0014-5793(03)00853-6. PMID 12935897.

[pmid18273061-7] Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (March 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.

[pmid11894096-8] Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.

[pmid15128873-9] Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.

[pmid11067845-10] Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H (February 2001). "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction". J. Biol. Chem. 276 (7): 4957–63. doi:10.1074/jbc.M005784200. PMID 11067845.

[pmid12559036-11] Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C et al. (February 2003). "CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl". Traffic 4 (2): 97–112. doi:10.1034/j.1600-0854.2003.40205.x. PMID 12559036.

[pmid11847211-12] Mancini A, Koch A, Wilms R, Tamura T (April 2002). "c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms". J. Biol. Chem. 277 (17): 14635–40. doi:10.1074/jbc.M109214200. PMID 11847211.

[pmid9461587-13] Gesbert F, Garbay C, Bertoglio J (February 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". J. Biol. Chem. 273 (7): 3986–93. doi:10.1074/jbc.273.7.3986. PMID 9461587.

[pmid9178909-14] Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B (May 1997). "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene 14 (19): 2331–8. doi:10.1038/sj.onc.1201074. PMID 9178909.

[pmid10204582-15] Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (April 1999). "Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages". J. Leukoc. Biol. 65 (4): 523–34. PMID 10204582.

[pmid11133830-16] Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". Int. Immunol. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.

[pmid9820532-17] Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J et al. (November 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". J. Immunol. 161 (10): 5555–63. PMID 9820532.

[pmid9590251-18] Park RK, Kyono WT, Liu Y, Durden DL (May 1998). "CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling". J. Immunol. 160 (10): 5018–27. PMID 9590251.

[pmid12244174-19] Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST (October 2002). "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J. Immunol. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.

[pmid9092574-20] Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV et al. (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". J. Biol. Chem. 272 (15): 10248–53. doi:10.1074/jbc.272.15.10248. PMID 9092574.

[pmid9162067-21] Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF et al. (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". J. Biol. Chem. 272 (22): 14320–6. doi:10.1074/jbc.272.22.14320. PMID 9162067.

[pmid9344843-22] Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N et al. (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochem. Biophys. Res. Commun. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.

[pmid12061819-23] Tvorogov D, Carpenter G (July 2002). "EGF-dependent association of phospholipase C-gamma1 with c-Cbl". Exp. Cell Res. 277 (1): 86–94. doi:10.1006/excr.2002.5545. PMID 12061819.

[pmid18508924-24] Umebayashi K, Stenmark H, Yoshimori T (August 2008). "Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation". Mol. Biol. Cell 19 (8): 3454–62. doi:10.1091/mbc.E07-10-0988. PMC 2488299. PMID 18508924.

[pmid11997436-25] Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A (May 2002). "FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6684–9. doi:10.1073/pnas.052138899. PMC 124463. PMID 11997436.

[pmid9535867-26] Deckert M, Elly C, Altman A, Liu YC (April 1998). "Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases". J. Biol. Chem. 273 (15): 8867–74. doi:10.1074/jbc.273.15.8867. PMID 9535867.

[pmid10570290-27] Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL (December 1999). "High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase". J. Immunol. 163 (11): 6023–34. PMID 10570290.

[pmid9174058-28] Jain SK, Langdon WY, Varticovski L (May 1997). "Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase". Oncogene 14 (18): 2217–28. doi:10.1038/sj.onc.1201049. PMID 9174058.

[pmid9872323-29] Liu SK, McGlade CJ (December 1998). "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc". Oncogene 17 (24): 3073–82. doi:10.1038/sj.onc.1202337. PMID 9872323.

[pmid10086340-30] Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH et al. (March 1999). "cbl-b inhibits epidermal growth factor receptor signaling". Oncogene 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. PMID 10086340.

[pmid9367879-31] Robertson H, Langdon WY, Thien CB, Bowtell DD (November 1997). "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochem. Biophys. Res. Commun. 240 (1): 46–50. doi:10.1006/bbrc.1997.7608. PMID 9367879.

[pmid8083187-32] Donovan JA, Wange RL, Langdon WY, Samelson LE (September 1994). "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor". J. Biol. Chem. 269 (37): 22921–4. PMID 8083187.

[pmid11964172-33] Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C (May 2002). "Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement". Biochem. J. 363 (Pt 3): 717–25. doi:10.1042/0264-6021:3630717. PMC 1222524. PMID 11964172.

[pmid9108392-34] Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T et al. (April 1997). "Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl". Blood 89 (8): 2745–56. PMID 9108392.

[pmid11896602-35] Howlett CJ, Robbins SM (March 2002). "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation". Oncogene 21 (11): 1707–16. doi:10.1038/sj.onc.1205228. PMID 11896602.

[pmid10092522-36] Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM (April 1999). "The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 (1): 129–38. doi:10.1006/bbrc.1999.0427. PMID 10092522.

[pmid18632619-37] Sehat B, Andersson S, Girnita L, Larsson O (July 2008). "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis". Cancer Res. 68 (14): 5669–77. doi:10.1158/0008-5472.CAN-07-6364. PMID 18632619.

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[pmid9234717-39] Bonita DP, Miyake S, Lupher ML, Langdon WY, Band H (August 1997). "Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity". Mol. Cell. Biol. 17 (8): 4597–610. PMC 232313. PMID 9234717.

[pmid9918857-40] Zhang S, Broxmeyer HE (January 1999). "p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells". Biochem. Biophys. Res. Commun. 254 (2): 440–5. doi:10.1006/bbrc.1998.9959. PMID 9918857.

[pmid18374639-41] Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ (June 2008). "FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival". Bone 42 (6): 1032–9. doi:10.1016/j.bone.2008.02.009. PMID 18374639.

[autogenerated1-42] Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". Int. Immunol. 13 (1): 13–22. doi:10.1093/intimm/13.1.13. PMID 11133830.

[pmid7629144-43] Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". J. Biol. Chem. 270 (31): 18260–3. doi:10.1074/jbc.270.31.18260. PMID 7629144.

[autogenerated2-44] Tvorogov D, Carpenter G (July 2002). "EGF-dependent association of phospholipase C-gamma1 with c-Cbl". Exp. Cell Res. 277 (1): 86–94. doi:10.1006/excr.2002.5545. PMID 12061819.

[pmid9712732-45] Graham LJ, Stoica BA, Shapiro M, DeBell KE, Rellahan B, Laborda J et al. (August 1998). "Sequences surrounding the Src-homology 3 domain of phospholipase Cgamma-1 increase the domain's association with Cbl". Biochem. Biophys. Res. Commun. 249 (2): 537–41. doi:10.1006/bbrc.1998.9177. PMID 9712732.

[pmid11149930-46] Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E et al. (January 2001). "Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility". J. Cell Biol. 152 (1): 181–95. doi:10.1083/jcb.152.1.181. PMC 2193648. PMID 11149930.

[pmid18519587-47] Tanaka Y, Tanaka N, Saeki Y, Tanaka K, Murakami M, Hirano T et al. (August 2008). "c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130". Mol. Cell. Biol. 28 (15): 4805–18. doi:10.1128/MCB.01784-07. PMC 2493370. PMID 18519587.

[pmid10374881-48] Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S et al. (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881.

[pmid11071869-49] Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. Res. Commun. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.

[pmid11894095-50] Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.

[pmid12177062-51] Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.

[pmid11152963-52] Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J et al. (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. Signal. 12 (11-12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.

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[pmid12504111-54] Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I (January 2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2". Biochem. Biophys. Res. Commun. 300 (2): 494–500. doi:10.1016/S0006-291X(02)02894-2. PMID 12504111.

[pmid12234920-55] Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY et al. (September 2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.

[pmid11053437-56] Wong ES, Lim J, Low BC, Chen Q, Guy GR (February 2001). "Evidence for direct interaction between Sprouty and Cbl". J. Biol. Chem. 276 (8): 5866–75. doi:10.1074/jbc.M006945200. PMID 11053437.

[pmid9857068-57] Lupher ML, Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA et al. (December 1998). "Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323". J. Biol. Chem. 273 (52): 35273–81. doi:10.1074/jbc.273.52.35273. PMID 9857068.

[pmid11331248-58] Bertagnolo V, Marchisio M, Brugnoli F, Bavelloni A, Boccafogli L, Colamussi ML et al. (April 2001). "Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells". Cell Growth Differ. 12 (4): 193–200. PMID 11331248.

[pmid12435267-59] Melander F, Andersson T, Dib K (March 2003). "Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils". Biochem. J. 370 (Pt 2): 687–94. doi:10.1042/BJ20021201. PMC 1223185. PMID 12435267.

[pmid10531381-60] Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H et al. (October 1999). "Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7". J. Biol. Chem. 274 (44): 31707–12. doi:10.1074/jbc.274.44.31707. PMID 10531381.

[pmid10966114-61] Zheng N, Wang P, Jeffrey PD, Pavletich NP (August 2000). "Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases". Cell 102 (4): 533–9. doi:10.1016/S0092-8674(00)00057-X. PMID 10966114.

[pmid9200440-62] Marengère LE, Mirtsos C, Kozieradzki I, Veillette A, Mak TW, Penninger JM (July 1997). "Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells". J. Immunol. 159 (1): 70–6. PMID 9200440.

[pmid11024037-63] Pedraza-Alva G, Sawasdikosol S, Liu YC, Mérida LB, Cruz-Muñoz ME, Oceguera-Yañez F et al. (January 2001). "Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells". J. Biol. Chem. 276 (1): 729–37. doi:10.1074/jbc.M008494200. PMID 11024037.

[pmid8663231-64] Liu YC, Elly C, Yoshida H, Bonnefoy-Berard N, Altman A (June 1996). "Activation-modulated association of 14-3-3 proteins with Cbl in T cells". J. Biol. Chem. 271 (24): 14591–5. doi:10.1074/jbc.271.24.14591. PMID 8663231.

[pmid8798643-65] Lupher ML, Reedquist KA, Miyake S, Langdon WY, Band H (September 1996). "A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells". J. Biol. Chem. 271 (39): 24063–8. doi:10.1074/jbc.271.39.24063. PMID 8798643.

[pmid10078535-66] Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ (March 1999). "Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase". Nature 398 (6722): 84–90. doi:10.1038/18050. PMID 10078535.

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v-Cbl