- n.
WordNet
- move or pull with a sudden motion
- make an uncontrolled, short, jerky motion; "his face is twitching" (同)jerk
- a sudden muscle spasm; especially one caused by a nervous condition (同)twitching, vellication
- a painful and involuntary muscular contraction (同)cramp, muscle_spasm
- (pathology) sudden constriction of a hollow organ (as a blood vessel)
- aggravation by deriding or mocking or criticizing (同)taunt, taunting
PrepTutorEJDIC
- (無意識に)ぴくんと動く / (…を)急にぐいと引く《+at+名》 / 〈体〉一部〉‘を'ぴくっと動かす / …‘を'急にぐいと引く(引っ張る) / (無意識に)ぴくぴく動くこと,(筋肉の)けいれん / (…を)ぐいと引くこと《+at+名》
- (筋肉などの)けいれん / (感情・活動などの)発作《+『of』+『名』》
- (…のことで)〈人〉‘を'あざける,からかう《+名〈人〉+about(on,with)+名》 / 《英俗》ばか,あほう
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/11 02:05:54」(JST)
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- 1. 若年性ミオクローヌスてんかん juvenile myoclonic epilepsy
- 2. 眼筋型重症筋無力症 ocular myasthenia gravis
- 3. 線維筋痛症の鑑別診断 differential diagnosis of fibromyalgia
- 4. 女性における筋膜性骨盤痛症候群の臨床症状および診断 clinical manifestations and diagnosis of myofascial pelvic pain syndrome in women
- 5. 筋萎縮性側索硬化症およびその他の運動ニューロン疾患の診断 diagnosis of amyotrophic lateral sclerosis and other forms of motor neuron disease
English Journal
- N-acetylcysteine modulates hallucinogenic 5-HT2A receptor agonist-mediated responses: Behavioral, molecular, and electrophysiological studies.
- Lee MY1, Chiang CC2, Chiu HY3, Chan MH4, Chen HH5.Author information 1Department of Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien 97004, Taiwan.2School of Medicine, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien 97004, Taiwan.3Department of Pharmacy, Hualien, Tzu Chi General Hospital, 707, Section 3, Chung-Yang Road, Hualien 97004, Taiwan.4Institute of Neuroscience, National Changchi University, 64, Sec. 2, ZhiNan Road, Wenshan District, Taipei City 11605, Taiwan; Research Center for Mind, Brain, and Learning, National Changchi University, 64, Sec. 2, ZhiNan Road, Wenshan District, Taipei City 11605, Taiwan.5Department of Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien 97004, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan. Electronic address: hwei5514@gmail.com.AbstractN-acetylcysteine (NAC) has been reported to reverse the psychotomimetic effects in the rodent phencyclidine model of psychosis and shown beneficial effects in treating patients with schizophrenia. The effect of NAC has been associated with facilitating the activity of cystine-glutamate antiporters on glial cells concomitant with the release of non-vesicular glutamate, which mainly stimulates the presynaptic metabotropic glutamate receptor subtype 2 receptors (mGluR2). Recent evidence demonstrated that functional interactions between serotonin 5-HT2A receptor (5-HT2AR) and mGluR2 are responsible to unique cellular responses when targeted by hallucinogenic drugs. The present study determined the effects of NAC on hallucinogenic 5-HT2AR agonist (±)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-elicited behavioral and molecular responses in mice and DOI-evoked field potentials in the mouse cortical slices. NAC significantly attenuated DOI-induced head twitch response and expression of c-Fos and Egr-2 in the infralimbic and motor cortex and suppressed the increase in the frequency of excitatory field potentials elicited by DOI in the medial prefrontal cortex. In addition, the cystine-glutamate antiporter inhibitor (S)-4-carboxyphenylglycine (CPG) and the mGluR2 antagonist LY341495 reversed the suppressing effects of NAC on DOI-induced head twitch and molecular responses and increased frequency of excitatory field potentials, supporting that NAC attenuates the 5-HT2AR-mediated hallucinogenic effects via increased activity of cystine-glutamate antiporter followed by activation of mGluR2 receptors. These findings implicate NAC as a potential therapeutic agent for hallucinations and psychosis associated with hallucinogen use and schizophrenia.
- Neuropharmacology.Neuropharmacology.2014 Jun;81:215-23. doi: 10.1016/j.neuropharm.2014.02.006. Epub 2014 Feb 15.
- N-acetylcysteine (NAC) has been reported to reverse the psychotomimetic effects in the rodent phencyclidine model of psychosis and shown beneficial effects in treating patients with schizophrenia. The effect of NAC has been associated with facilitating the activity of cystine-glutamate antiporters o
- PMID 24534112
- Glutamine deficiency in extracellular fluid exerts adverse effects on protein and amino acid metabolism in skeletal muscle of healthy, laparotomized, and septic rats.
- Holecek M1, Sispera L.Author information 1Department of Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic, holecek@lfhk.cuni.cz.AbstractCharacteristic feature of critical illness, such as trauma and sepsis, is muscle wasting associated with activated oxidation of branched-chain amino acids (valine, leucine, isoleucine) and enhanced release of glutamine (GLN) to the blood. GLN consumption in visceral tissues frequently exceeds its release from muscle resulting in GLN deficiency that may exert adverse effects on the course of the disease. In the present study, we investigated the effects of GLN depletion in extracellular fluid on GLN production and protein and amino acid metabolism in skeletal muscle of healthy, laparotomized, and septic rats. Cecal ligation and puncture (CLP) was used as a model of sepsis. After 24 h, soleus muscle (SOL, slow-twitch, red muscle) and extensor digitorum longus (EDL, fast-twitch, white muscle) were isolated and incubated in a medium containing 0.5 mM GLN or without GLN. L-[1-(14)C]leucine was used to estimate protein synthesis and leucine oxidation, 3-methylhistidine release was used to evaluate myofibrillar protein breakdown. CLP increased GLN release from muscle, protein breakdown and leucine oxidation, and decreased protein synthesis. The effects were more pronounced in EDL. Alterations induced by laparotomy were similar to those observed in sepsis, but of a lower extent. GLN deficiency in medium enhanced GLN release and decreased intramuscular GLN concentration, decreased protein synthesis in muscles of intact and laparotomized rats, and enhanced leucine oxidation in SOL of intact and protein breakdown in SOL of laparotomized rats. It is concluded that (1) fast-twitch fibers are more sensitive to septic stimuli than slow-twitch fibers, (2) extracellular GLN deficiency may exert adverse effects on protein and amino acid metabolism in skeletal muscle, and (3) muscles of healthy and laparotomized animals are more sensitive to GLN deficiency than muscles of septic animals.
- Amino acids.Amino Acids.2014 May;46(5):1377-84. doi: 10.1007/s00726-014-1701-7. Epub 2014 Mar 8.
- Characteristic feature of critical illness, such as trauma and sepsis, is muscle wasting associated with activated oxidation of branched-chain amino acids (valine, leucine, isoleucine) and enhanced release of glutamine (GLN) to the blood. GLN consumption in visceral tissues frequently exceeds its re
- PMID 24609272
- Dosing schedule-dependent attenuation of dexamethasone-induced muscle atrophy in mice.
- Nakao R1, Yamamoto S, Yasumoto Y, Oishi K.Author information 1Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) , Tsukuba, Ibaraki , Japan .AbstractMany inflammatory and autoimmune diseases are treated using synthetic glucocorticoids. However, excessive glucocorticoid can often cause unpredictable effects including muscle atrophy. Endogenous glucocorticoid levels robustly fluctuate in a circadian manner and peak just before the onset of the active phase in both humans and nocturnal rodents. The present study determines whether muscle atrophy induced by exogenous glucocorticoid can be avoided by optimizing dosing times. We administered single daily doses of the glucocorticoid analog dexamethasone (Dex) to mice for 10 days at the times of day corresponding to peak (early night) or trough (early morning) endogenous glucocorticoid levels. Administration at the acrophase of endogenous glucocorticoids significantly attenuated Dex-induced wasting of the gastrocnemius (Ga) and tibialis anterior (TA) muscles that comprise mostly fast-twitch muscle fibers. Real-time RT-PCR revealed that the Dex-induced mRNA expression of genes encoding the atrophy-related ubiquitin ligases Muscle Atrophy F-box (Fbxo32, also known as MAFbx/Atrogin-1) and Muscle RING finger 1 (Trim63, also known as MuRF1) in the Ga and TA muscles was significantly attenuated by Dex when administered during the early night. Dex negligibly affected the weight of the soleus (So) muscle that mostly comprises slow-twitch muscle fibers, but significantly and similarly decreased the weight of the spleen at both dosing times. These results suggest that glucocorticoid-induced muscle atrophy can be attenuated by optimizing the dosing schedule.
- Chronobiology international.Chronobiol Int.2014 May;31(4):506-14. doi: 10.3109/07420528.2013.872654. Epub 2014 Jan 7.
- Many inflammatory and autoimmune diseases are treated using synthetic glucocorticoids. However, excessive glucocorticoid can often cause unpredictable effects including muscle atrophy. Endogenous glucocorticoid levels robustly fluctuate in a circadian manner and peak just before the onset of the act
- PMID 24397304
- Lateralizing epidural catheter placement as evidenced by electrical stimulation.
- Sharrock NE1, Go G.Author information 1Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA, sharrockn@hss.edu.AbstractBACKGROUND: Epidural steroids are more effective if administered in the anterolateral epidural space. It follows that the ability to administer local anesthetics in the ipsilateral anterolateral epidural space should likewise improve their efficacy for postoperative epidural analgesia.
- Clinical orthopaedics and related research.Clin Orthop Relat Res.2014 May;472(5):1449-52. doi: 10.1007/s11999-013-3452-2.
- BACKGROUND: Epidural steroids are more effective if administered in the anterolateral epidural space. It follows that the ability to administer local anesthetics in the ipsilateral anterolateral epidural space should likewise improve their efficacy for postoperative epidural analgesia.QUESTIONS/PURP
- PMID 24398887
Japanese Journal
- 漸増負荷下における自転車エルゴメータ駆動時の外側広筋と大腿直筋の筋活動変曲点と換気性作業閾値の時間的関係:―若年者と高齢者における検討―
- 理学療法学 advpub(0), 2016
- NAID 130005160916
- 股関節外転動作時における中殿筋の筋活動の左右差
- 理学療法科学 31(2), 285-288, 2016
- NAID 130005149331
- 生体内在性オピオイドの性質と機能的役割
- YAKUGAKU ZASSHI 136(4), 591-605, 2016
- NAID 130005140772
- High-intensity interval training enhances oxidative capacity and substrate availability in skeletal muscle
- The Journal of Physical Fitness and Sports Medicine 5(1), 13-23, 2016
- NAID 130005138386
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★リンクテーブル★
| リンク元 | 「spasm」「単収縮」 |
| 関連記事 | 「twitching」 |
「spasm」
- n.
- 関
- contracture、convulsion、convulsive、cramp、generalized spasm、muscle spasm、muscular spasm、seizure、spasticity、twitch、twitching
「単収縮」
「twitching」
- n.