関: E2F-1 protein、E2F-1 transcription factor、E2F1 transcription factor、transcription factor E2F-1

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
(genetics) the organic process whereby the DNA sequence in a gene is copied into mRNA; the process whereby a base sequence of messenger RNA is synthesized on a template of complementary DNA
a sound or television recording (e.g., from a broadcast to a tape recording)
something written, especially copied from one medium to another, as a typewritten version of dictation (同)written text

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
〈U〉(…を)書き写す(書き直す)こと,(…の)転写,謄写《+of+名》 / 〈C〉写し(書き直し)[たもの] / 〈U〉〈C〉編曲[されたもの] / 〈U〉〈C〉(ラジオ・テレビの)録音(録画)

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Inoue K1, Fry EA1, Frazier DP1.
International journal of cancer. Journal international du cancer.Int J Cancer.2016 Apr 1;138(7):1577-85. doi: 10.1002/ijc.29663. Epub 2015 Jul 14.
The tumor suppressor p53 is activated upon cellular stresses such as DNA damage, oncogene activation, hypoxia, which transactivates sets of genes that induce DNA repair, cell cycle arrest, apoptosis, or autophagy, playing crucial roles in the prevention of tumor formation. The central regulator of t
PMID 26132471

Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures.

Wang Y1, Alla V1, Goody D1, Gupta SK2, Spitschak A1, Wolkenhauer O2, Pützer BM3, Engelmann D1.
Nucleic acids research.Nucleic Acids Res.2016 Jan 8;44(1):117-33. doi: 10.1093/nar/gkv885. Epub 2015 Sep 8.
Transcription factor E2F1 is a key regulator of cell proliferation and apoptosis. Recently, it has been shown that aberrant E2F1 expression often detectable in advanced cancers contributes essentially to cancer cell propagation and characterizes the aggressive potential of a tumor. Conceptually, thi
PMID 26350215

Xu HG1,2, Liu L1, Gao S1, Jin R1, Ren W1, Zhou GP3.
Immunologic research.Immunol Res.2016 Jan 6. [Epub ahead of print]
The interferon regulatory factor 3 (IRF-3) plays essential roles in inflammation and immune response. Here, we cloned the nucleotide sequence of the 5'-flanking region of the murine IRF-3 gene (mIRF-3) and characterized the molecular mechanisms controlling the mIRF-3 transcriptional activity in NIH3
PMID 26740329

Enhanced Herpes Simplex Virus Type 1 (HSV-1) Production in Phytohemagglutinin (PHA)-activated T Lymphocytes Caused by Up-regulated E2F Transcription Factor 1 (E2F1)

Truncated serine/arginine-rich splicing factor 3 accelerates cell growth through up-regulating c-Jun expression

Kano Shizuka,Nishida Kensei,Nishiyama Chihiro,Akaike Yoko,Kajita Keisuke,Kurokawa Ken,Masuda Kiyoshi,Kuwano Yuki,Tanahashi Toshihito,Rokutan Kazuhito
The Journal of Medical Investigation 60(3.4), 228-235, 2013
… Serine/arginine-rich splicing factor 3 (SRSF3), a member of the SRSF family, plays a wide-ranging role in gene expression. … The SRSF3-TR-expressing cells increased mRNA and protein levels of positive regulators for G1 to S phase transition (cyclin D1, cyclin D3, CDC25A, and E2F1) and accelerated their growth. … The SRSF3-TR-expressing cells increased c-Jun and Sp-1 levels, which are important for the positive autoregulation and basal transcription of JUN, respectively. …
NAID 130004822687