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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/27 18:37:39」(JST)

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English Journal

  • Drug-Induced QTC Prolongation Dangerously Underestimates Proarrhythmic Potential: Lessons From Terfenadine.
  • Hondeghem LM, Dujardin K, Hoffmann P, Dumotier B, De Clerck F.SourceFrom the *Department of Pharmacology, KU Leuven, Leuven, Belgium; †Department of Cardiology, H. Hart Ziekenhuis, Roeselare, Belgium; ‡Novartis Pharmaceuticals Corp, East Hanover NJ; §Safety Pharmacology, Novartis Pharma AG, Basel, Switzerland; and ?PharmaConsulting, Beerse, Belgium.
  • Journal of cardiovascular pharmacology.2011 May;57(5):589-97.
  • PMID 21346598

Japanese Journal

  • Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium
  • Nouchi Hideaki,Kiryu Naoaki,Kimata Mikio,Tsuneoka Yayoi,Hamaguchi Shogo,Namekata Iyuki,Takahara Akira,Shigenobu Koki,Tanaka Hikaru
  • Journal of Pharmacological Sciences 115(2), 235-238, 2011
  • Terfenadine prolonged action potential duration in the 11 – …
  • NAID 130000439947
  • Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy–Induced Itch-Associated Responses in Mice
  • Andoh Tsugunobu,Zhang Qun,Yamamoto Takumi,Tayama Manabu,Hattori Masao,Tanaka Ken,Kuraishi Yasushi
  • Journal of Pharmacological Sciences advpub(0), 1010060458, 2010
  • … The scratching was inhibited by the H1 histamine–receptor antagonist azelastine, but not by the peripherally acting H1-antagonist terfenadine, at the oral dose of 30 mg/kg. … Although terfenadine (30 mg/kg) inhibited plasma extravasation induced by ESGM in the sensitized mice, G. …
  • NAID 130000439885

Related Links

Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi- Aventis) and marketed under various brand names including Seldane in the United ...

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トリルダン, Seldane

  • 第二世代ヒスタミン薬
  • 抗アレルギー薬
  • 抗ヒスタミン薬
  • ピペリジン系


  • QT延長、心房性不整脈(torsades de pointes)を起こし、心停止を起こしうる
  • テルフェナジンはプロドラッグであり、99.5%がすぐ代謝されフェキソフェナジンとなる
  • 代謝が滞るとテルフェナジンは電位依存性Kチャネルを抑制するので危険。
  • テルフェナジン代謝酵素はCYP3A4で代謝されるので、これを阻害する薬物(CYP3A4と親和性の高い薬物)との併用は危険
  • 服用に注意を要するのはQT延長をおこしやすい人