polymeric immunoglobulin receptor

同

poly-lg receptor

同

poly-lg receptor

WordNet

1. a naturally occurring or synthetic compound consisting of large molecules made up of a linked series of repeated simple monomers
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
3. a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin
4. of or relating to or consisting of a polymer; "a polymeric compound"

PrepTutorEJDIC

1. 重合体(合一化物の分子が重合した高分子化合物)
2. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/24 22:32:42」(JST)

wiki en

[Wiki en表示]

Polymeric immunoglobulin receptor
PDB rendering based on 1xed.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1XED, 2OCW, 3CHN, 3CM9
Identifiers
Symbols	PIGR; FLJ22667; MGC125361; MGC125362
External IDs	OMIM: 173880 MGI: 103080 HomoloGene: 1984 GeneCards: PIGR Gene
Gene Ontology Molecular function • protein binding Cellular component • extracellular region • integral to plasma membrane • transport vesicle • recycling endosome membrane Biological process • protein secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5284	18703
Ensembl	ENSG00000162896	ENSMUSG00000026417
UniProt	P01833	O70570
RefSeq (mRNA)	NM_002644	NM_011082
RefSeq (protein)	NP_002635	NP_035212
Location (UCSC)	Chr 1: 207.1 – 207.12 Mb	Chr 1: 130.83 – 130.85 Mb
PubMed search	[1]	[2]

Polymeric immunoglobulin receptor is a protein that in humans is encoded by the PIGR gene. It is a Fc receptor which facilitates the secretion of immunoglobulin A and immunoglobulin M.

The poly-Ig receptor is expressed on several glandular epithelia including those of liver and breast. It mediates transcellular transport of polymeric immunoglobulin molecules. It is a member of the immunoglobulin superfamily (Hood et al., 1985). The receptor has 5 units with homology to the variable (V) units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions.[supplied by OMIM]

References

Further reading

• Kaetzel CS (2005). "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces.". Immunol. Rev. 206: 83–99. doi:10.1111/j.0105-2896.2005.00278.x. PMID 16048543.
• Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992). "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)". Eur. J. Immunol. 22 (9): 2309–15. doi:10.1002/eji.1830220920. PMID 1355431.
• Krajci P, Grzeschik KH, Geurts van Kessel AH, et al. (1991). "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization.". Hum. Genet. 87 (6): 642–8. doi:10.1007/BF00201717. PMID 1682231.
• Eiffert H, Quentin E, Wiederhold M, et al. (1991). "Determination of the molecular structure of the human free secretory component.". Biol. Chem. Hoppe-Seyler 372 (2): 119–28. doi:10.1515/bchm3.1991.372.1.119. PMID 1859628.
• Bakos MA, Kurosky A, Goldblum RM (1991). "Characterization of a critical binding site for human polymeric Ig on secretory component". J. Immunol. 147 (10): 3419–26. PMID 1940346.
• Krajci P, Solberg R, Sandberg M, et al. (1989). "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues". Biochem. Biophys. Res. Commun. 158 (3): 783–9. doi:10.1016/0006-291X(89)92790-3. PMID 2920039.
• Davidson MK, Le Beau MM, Eddy RL, et al. (1989). "Genetic mapping of the human polymeric immunoglobulin receptor gene to chromosome region 1q31----q41". Cytogenet. Cell Genet. 48 (2): 107–11. doi:10.1159/000132601. PMID 3197448.
• Hood L, Kronenberg M, Hunkapiller T (1985). "T cell antigen receptors and the immunoglobulin supergene family". Cell 40 (2): 225–9. doi:10.1016/0092-8674(85)90133-3. PMID 3917857.
• Eiffert H, Quentin E, Decker J, et al. (1985). "[The primary structure of human free secretory component and the arrangement of disulfide bonds]". Hoppe-Seyler's Z. Physiol. Chem. 365 (12): 1489–95. PMID 6526384.
• Mizoguchi A, Mizuochi T, Kobata A (1982). "Structures of the carbohydrate moieties of secretory component purified from human milk". J. Biol. Chem. 257 (16): 9612–21. PMID 7107583.
• Coyne RS, Siebrecht M, Peitsch MC, Casanova JE (1995). "Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I". J. Biol. Chem. 269 (50): 31620–5. PMID 7989333.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Piskurich JF, France JA, Tamer CM, et al. (1993). "Interferon-gamma induces polymeric immunoglobulin receptor mRNA in human intestinal epithelial cells by a protein synthesis dependent mechanism". Mol. Immunol. 30 (4): 413–21. doi:10.1016/0161-5890(93)90071-I. PMID 8455639.
• Piskurich JF, Youngman KR, Phillips KM, et al. (1997). "Transcriptional regulation of the human polymeric immunoglobulin receptor gene by interferon-gamma". Mol. Immunol. 34 (1): 75–91. doi:10.1016/S0161-5890(96)00079-X. PMID 9182878.
• Hughes GJ, Frutiger S, Savoy LA, et al. (1997). "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor". FEBS Lett. 410 (2–3): 443–6. doi:10.1016/S0014-5793(97)00629-7. PMID 9237679.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ackermann LW, Wollenweber LA, Denning GM (1999). "IL-4 and IFN-gamma increase steady state levels of polymeric Ig receptor mRNA in human airway and intestinal epithelial cells". J. Immunol. 162 (9): 5112–8. PMID 10227981.
• Røe M, Norderhaug IN, Brandtzaeg P, Johansen FE (1999). "Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction". J. Immunol. 162 (10): 6046–52. PMID 10229845.
• Norderhaug IN, Johansen FE, Krajci P, Brandtzaeg P (1999). "Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction". European Journal of Immunology 29 (10): 3401–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3401::AID-IMMU3401>3.0.CO;2-G. PMID 10540352.
• Mostov KE, Friedlander M, Blobel G. (1984). "The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains". Nature 308 (5954): 37–43. doi:10.1038/308037a0. PMID 6322002.
• Hughes GJ, Reason AJ, Savoy L, et al. (1999). "Carbohydrate moieties in human secretory component". Biochim. Biophys. Acta 1434 (1): 86–93. doi:10.1016/S0167-4838(99)00168-5. PMID 10556562.

External links

• Polymeric+Immunoglobulin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. IgGの構造および生物学的機能 structure and biologic functions of iga
• 2. 免疫グロブリンの構造 structure of immunoglobulins
• 3. 選択的IgA欠損症：臨床症状、病態生理、および診断 selective iga deficiency clinical manifestations pathophysiology and diagnosis
• 4. 原発性免疫不全の胃腸症状 gastrointestinal manifestations in primary immunodeficiency

English Journal

• Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.

• Rodríguez-Nunez I1, Wcisel DJ1, Litman GW2, Yoder JA3.
• Developmental and comparative immunology.Dev Comp Immunol.2014 Sep;46(1):24-34. doi: 10.1016/j.dci.2014.02.004. Epub 2014 Feb 15.
• Five large multigene families encoding innate-type immune receptors that are comprised of immunoglobulin domains have been identified in bony fish, of which four do not possess definable mammalian orthologs. The members of some of the multigene families exhibit unusually extensive patterns of diverg
• PMID 24548770

• Gastric De Novo Muc13 Expression and Spasmolytic Polypeptide-Expressing Metaplasia during Helicobacter heilmannii Infection.

• Liu C1, Smet A2, Blaecher C1, Flahou B1, Ducatelle R1, Linden S3, Haesebrouck F1.
• Infection and immunity.Infect Immun.2014 Aug;82(8):3227-39. doi: 10.1128/IAI.01867-14. Epub 2014 May 27.
• Helicobacter heilmannii is a zoonotic bacterium that has been associated with gastric disease in humans. In this study, the mRNA expression of mucins in the stomach of BALB/c mice was analyzed at several time points during a 1-year infection with this bacterium, during which gastric disease progress
• PMID 24866791

• Polymeric Immunoglobulin Receptor Downregulation in COPD: Persistence in the Cultured Epithelium and Role of Transforming Growth Factor-β.

• Gohy ST1, Detry BR, Lecocq M, Bouzin C, Weynand BA, Amatngalim GD, Sibille YM, Pilette C.
• American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2014 Jul 31. [Epub ahead of print]
• Rationale: The generation of protective secretory immunoglobulin A (IgA) relies on the epithelial polymeric immunoglobulin receptor (pIgR). pIgR expression is reduced in chronic obstructive pulmonary disease (COPD), but correlation to disease severity and underlying mechanisms remain unknown. Object
• PMID 25078120

Japanese Journal

• The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake

• Shibuya Takumi,Kaburagi Tomoko,Nagai Ryoji,Oshiro Satoru
• Journal of Clinical Biochemistry and Nutrition 57(1), 44-49, 2015
• … Secretory immunoglobulin A (sIgA) is produced from intestinal mucosa and is essential in preventing infection. … Expression of the polymeric immunoglobulin receptor (pIgR) in the small intestine was significantly higher in the exercise group fed a HC diet. …
• NAID 130005085260

• The effects of moderate exercise on secretory IgA production in mice depends on dietary carbohydrate intake

• Shibuya Takumi,Kaburagi Tomoko,Nagai Ryoji,Oshiro Satoru
• Journal of Clinical Biochemistry and Nutrition advpub(0), 2015
• … Secretory immunoglobulin A (sIgA) is produced from intestinal mucosa and is essential in preventing infection. … Expression of the polymeric immunoglobulin receptor (pIgR) in the small intestine was significantly higher in the exercise group fed a HC diet. …
• NAID 130005074645

• P-52 Secretory leukocyte protease inhibitor (SLPI)によるPolymeric immunoglobulin receptor発現調節(免疫組織化学・機能解析関連領域,ポスター,第54回日本組織細胞化学会総会・学術集会)

• 岩瀬 孝志,小宮山 一雄,山村 崇之,西川 洋一,尾曲 大輔
• 日本組織細胞化学会総会プログラムおよび抄録集 (54), 100, 2013-09-10
• NAID 110009762840

Related Links

• Polymeric immunoglobulin receptor. - National Center for ...

1. J Oral Sci. 2011 Jun;53(2):147-56. Polymeric immunoglobulin receptor. Asano M, Komiyama K. Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan. asano-m@dent.nihon-u.ac.jp The surface of mucosal ...

• The Polymeric Immunoglobulin Receptor - eLS: Citable ...

Figure 4. Schematic structure of the human polymeric immunoglobulin receptor (pIgR). The pIgR is a type I transmembrane protein, with an N‐terminal extracellular region comprising five domains with homology to immunoglobulin ...

Related Pictures

---

★リンクテーブル★

リンク元	「分泌成分」「多量体免疫グロブリン受容体」「多量体免疫グロブリンレセプター」「pIgR」
関連記事	「polymer」「polymeric」

「分泌成分」

　　[★]

英

secretory component SC

同

S成分 S component、分泌片 secretory piece、輸送片 transport piece、多量体免疫グロブリン受容体 polymeric immunoglobulin receptor

関

分泌因子、分泌片

[show details]

分泌成分 : 約 8,080 件
S成分 : 約 8,690 件
分泌因子 : 約 3,320 件
分泌片 : 65 件
輸送片 : 15 件
多量体免疫グロブリン受容体 : 19 件

「多量体免疫グロブリン受容体」

　　[★]

英

polymeric immunoglobulin receptor pIgR

関

多量体免疫グロブリンレセプター

関

分泌成分

「多量体免疫グロブリンレセプター」

　　[★]

英

polymeric immunoglobulin receptor

関

多量体免疫グロブリン受容体

「pIgR」

　　[★]

• 多量体免疫グロブリン受容体

関

polymeric immunoglobulin receptor

「polymer」

　　[★]

• ポリマー、重合体、(タンパク質の)多量体、高分子、高分子化合物

関

high molecular weight、macromolecular、macromolecular substance、macromolecule、multimer、multimeric、polymeric

　 　

「polymeric」

　　[★]

• 重合体の

関

polymer