WordNet
- join during spinning; "piece the broken pieces of thread, slivers, and rovings"
- repair by adding pieces; "She pieced the china cup" (同)patch
- a distance; "it is down the road a piece"
- a separate part of a whole; "an important piece of the evidence"
- an item that is an instance of some type; "he designed a new piece of equipment"; "she bought a lovely piece of china";
- an instance of some kind; "it was a nice piece of work"; "he had a bit of good luck" (同)bit
- a serving that has been cut from a larger portion; "a piece of pie"; "a slice of bread" (同)slice
- an artistic or literary composition; "he wrote an interesting piece on Iran"; "the children acted out a comic piece to amuse the guests"
- dish baked in pastry-lined pan often with a pastry top
- of or relating to or producing a secretion; " a secretory cell"
PrepTutorEJDIC
- (全体から分離した)『部分』,『断片』,破片 / (…の)…『個』,『片』,枚《+『of』+『名』》 / (セット・グループを構成するものの)一つ;(ゲームで使う)こま,チェスの歩(pawn)以外のこま / 《英》硬貨(coin) / (音楽・美術・文学などの)作品《+『of』+『名』》 / 銃,砲,ピストル / 《単位として》(布などの)1反,一巻き《+『of』+『名』》;《the~》仕事量 / 《俗》(性交の対象としての)女 / …‘を'継ぎ合わせる / …‘を'継ぎ合わせて作る / …‘を'繕う
- パイ
- =pi
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/03 06:50:41」(JST)
[Wiki en表示]
The dimeric IgA molecule.
1: H-chain.
2: L-chain.
3: J-chain.
4:
secretory component.
The secretory component is a component of immunoglobulin A (IgA). Secretory component is a proteolytic cleavage product of the polymeric immunoglobulin receptor which remains associated with dimeric IgA in sero-mucus secretions.[1] Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.[2]
Secretory components wrap around two IgA units joined by a J chain protein fragment, resulting in a >--< configuration, with each of the two antigen binding regions of the two constituent y-shaped antibodies exposed. One identified function of secretory components is to protect IgA antibodies from degradation by the gastric acids and enzymes of the digestive system. This property is especially important in the transfer of immune system components during breastfeeding.[3]
External links
- Secretory component at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ Roitt, Ivan; Delves, Peter (2001). Essential Immunology (10th ed.). Blackwell Science. p. 483. ISBN 0-632-05902-8.
- ^ CS Kaetzel, JK Robinson, KR Chintalacharuvu, JP Vaerman, and ME Lamm (1991). "The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA". Proc Natl Acad Sci USA 88 (19): 8796–8800. doi:10.1073/pnas.88.19.8796. PMC 52597. PMID 1924341.
- ^ Newman, Jack (December 1995). "How Breast Milk Protects Newborns". Scientific American: 76–80.
UpToDate Contents
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English Journal
- Identification, immunolocalization, and immunological characterization of nitric oxide synthase-interacting protein from Clonorchis sinensis.
- Bian M1, Li S, Wang X, Xu Y, Chen W, Zhou C, Chen X, He L, Xu J, Liang C, Wu Z, Huang Y, Li X, Yu X.Author information 1Department of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.AbstractRecently, accumulating evidences indicate that nitric oxide (NO) is a potent mediator with diverse roles in regulating cellular functions, signaling pathways, and variety of pathological processes. In the present study, using data from the published genomic for Clonorchis sinensis (C. sinensis), we investigated a gene encoding nitric oxide synthase-interacting protein (NOSIP) of C. sinensis. Recombinant CsNOSIP (rCsNOSIP) was expressed and purified from Escherichia coli BL21. The open reading frame of CsNOSIP comprises 867 bp which encodes 289 amino acids and shares 72.9, 45.2, 47, 46.4, and 45.8 % identity with NOSIP from Schistosoma mansoni, Xenopus laevis, Rattus norvegicus, Mus musculus, and Homo sapiens, respectively. Bioinformatics analysis suggested that the full-length sequence contains an eNOS-interacting domain and numerous B-cell epitopes. Quantitative RT-PCR indicated that CsNOSIP differentially transcribed throughout the adult worms, metacercariae, and egg stages of C. sinensis, and were highly expressed in the adult worms. Moreover, western blot analysis showed that the rCsNOSIP could be detected by the serum from BALB/c mice infected with C. sinensis and the serum from BALB/c mice immunized with excretory/secretory products (ESPs). Furthermore, immunolocalization assay showed that CsNOSIP was specifically localized in the intestine, vitellarium, and eggs of adult worm. Both immunoblot and immunolocalization results demonstrated that CsNOSIP was one component of ESPs of C. sinensis, which could be supported by SignalP analysis. Moreover, analysis of the antibody subclass and cytokine profile demonstrated that subcutaneously immunized BALB/c mice with rCsNOSIP could significantly enhance serum IgG1 level and up-regulate expression of IL-4 and IL-6 in the splenocytes. Our results suggested that CsNOSIP was an important antigen exposed to host immune system and probably involved in immune regulation of host by inducing Th2-polarized immune response.
- Parasitology research.Parasitol Res.2014 Mar 7. [Epub ahead of print]
- Recently, accumulating evidences indicate that nitric oxide (NO) is a potent mediator with diverse roles in regulating cellular functions, signaling pathways, and variety of pathological processes. In the present study, using data from the published genomic for Clonorchis sinensis (C. sinensis), we
- PMID 24604383
- A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis.
- Dubaissi E, Rousseau K, Lea R, Soto X, Nardeosingh S, Schweickert A, Amaya E, Thornton DJ, Papalopulu N.AbstractThe larval epidermis of Xenopus is a bilayered epithelium, which is an excellent model system for the study of the development and function of mucosal and mucociliary epithelia. Goblet cells develop in the outer layer while multiciliated cells and ionocytes sequentially intercalate from the inner to the outer layer. Here, we identify and characterise a fourth cell type, the small secretory cell (SSC). We show that the development of these cells is controlled by the transcription factor Foxa1 and that they intercalate into the outer layer of the epidermis relatively late, at the same time as embryonic hatching. Ultrastructural and molecular characterisation shows that these cells have an abundance of large apical secretory vesicles, which contain highly glycosylated material, positive for binding of the lectin, peanut agglutinin, and an antibody to the carbohydrate epitope, HNK-1. By specifically depleting SSCs, we show that these cells are crucial for protecting the embryo against bacterial infection. Mass spectrometry studies show that SSCs secrete a glycoprotein similar to Otogelin, which may form the structural component of a mucus-like protective layer, over the surface of the embryo, and several potential antimicrobial substances. Our study completes the characterisation of all the epidermal cell types in the early tadpole epidermis and reinforces the suitability of this system for the in vivo study of complex epithelia, including investigation of innate immune defences.
- Development (Cambridge, England).Development.2014 Mar 5. [Epub ahead of print]
- The larval epidermis of Xenopus is a bilayered epithelium, which is an excellent model system for the study of the development and function of mucosal and mucociliary epithelia. Goblet cells develop in the outer layer while multiciliated cells and ionocytes sequentially intercalate from the inner to
- PMID 24598166
Japanese Journal
- 清信 成一
- 歯科基礎医学会雑誌 31(3), 248-256, 1989
- 口唇の小唾液腺組織 (16歳・女性) を培養した時, 組織片の表面に唾液の分泌が見られ, その後唾液組織片の周辺から細胞増殖が見られた。この細胞を8代継代培養し, SV<SUB>40</SUB>を感染させトランスフォーム細胞を作り, 28個のコロニーが得られたが, その内3個のコロニーは細胞質内に分泌顆粒とムチンの産生が認められた。また, ヒト口唇の小唾液腺組織切片では, …
- NAID 130003815213
- Sjoegren症候群の免疫学的検討 II SV40によるヒト唾液腺導管細胞の樹立:第2報 SV40によるヒト唾液腺導管細胞の樹立
- 大澤 篤子,阪本 真弥,古内 寿,丸茂 町子,三条 大助,清水 義信
- 日本口腔科学会雑誌 37(4), 879-885, 1988
- … A piece of minor salivary gland was minced to 3mm<SUP>3</SUP> … These cells lines were characterized by the methods of haematoxylinalcian blue-PAS-masson staining for secretory granules and immunofluorescent staining with ASDA for salivary duct cells. … 2 cells lines were identified with mucous like cells because secretory granules were observed in cytoplasm of these cells, 4 cells lines were also identified with salivary duct cells because ASDA could specifically react to these cells. …
- NAID 130004335096
Related Links
- Definition of SECRETORY PIECE: A large polypeptide attached to dimers of the secreted form of IgA. Structurally unrelated to immunoglobulins and synthesized by epithelial cells in the se ... A large polypeptide attached to dimers ...
- see under component ... Look at other dictionaries: secretory component — (SC) a 70,000 dalton glycopeptide occurring in secretory IgA; synthesized not by the plasma cell producing the IgA but added while the IgA is crossing the ...
Related Pictures
★リンクテーブル★
[★]
- 英
- secretory component SC
- 同
- S成分 S component、分泌片 secretory piece、輸送片 transport piece、多量体免疫グロブリン受容体 polymeric immunoglobulin receptor
- 関
- 分泌因子、分泌片
[show details]
[★]
- 関
- division、fragment、moiety、part、partial、portion、region、shred
[★]