WordNet

bring into conformity with rules or principles or usage; impose regulations; "We cannot regulate the way people dress"; "This town likes to regulate" (同)regularize, regularise, order, govern
fix or adjust the time, amount, degree, or rate of; "regulate the temperature"; "modulate the pitch" (同)modulate
the hydrolysis of proteins into peptides and amino acids by cleavage of their peptide bonds
controlled or governed according to rule or principle or law; "well regulated industries"; "houses with regulated temperature"

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1. 癌における悪液質の病因、臨床的特徴および評価 pathogenesis clinical features and assessment of cancer cachexia
2. von Willebrand病の分類および病態生理 classification and pathophysiology of von willebrand disease
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4. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i
5. 栄養の吸収および吸収不良の機序 mechanisms of nutrient absorption and malabsorption

Adam Z.SourceThe Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel. Electronic address: zach.adam@mail.huji.ac.il.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Dec;1828(12):2933-2936. doi: 10.1016/j.bbamem.2013.05.013.
Progress in the field of regulated intramembrane proteolysis (RIP) in recent years has made its impact on plant biology as well. Although this field within plant research is still in its infancy, some interesting observations have started to emerge. Gene encoding orthologs of rhomboid proteases, sit
PMID 24099011

Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity.

Ye J.SourceDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9046, USA. Electronic address: jin.ye@utsouthwestern.edu.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Dec;1828(12):2926-2932. doi: 10.1016/j.bbamem.2013.05.005.
Regulated intramembrane proteolysis (RIP) is a signaling mechanism through which transmembrane precursor proteins are cleaved to liberate their cytoplasmic and/or luminal/extracellular fragments from membranes so that these fragments are able to function at a new location. Recent studies have indica
PMID 24099010

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.

Voss M, Schröder B, Fluhrer R.SourceAdolf Butenandt Institute for Biochemistry, Ludwig-Maximilians University Munich, Schillerstr. 44, 80336 Munich, Germany.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Dec;1828(12):2828-2839. doi: 10.1016/j.bbamem.2013.03.033.
Signal peptide peptidase (SPP) and the homologous SPP-like (SPPL) proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 belong to the family of GxGD intramembrane proteases. SPP/SPPLs selectively cleave transmembrane domains in type II orientation and do not require additional co-factors for proteolytic activi
PMID 24099004

JB review: The signaling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology

Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.

Maesako M,Uemura K,Kubota M,Hiyoshi K,Ando K,Kuzuya A,Kihara T,Asada M,Akiyama H,Kinoshita A
Neuroscience 177, 298-307, 2011-03-17
… Interestingly, we demonstrated that PS1 phosphorylation promoted insulin receptor (IR) cleavage and the IR intracellular domain (IR ICD) generated by γ-secretase led to a marked transactivation of Akt (PKB), which down-regulated GSK3β activity. …
NAID 120002970866