- 関
- intramembranous
UpToDate Contents
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English Journal
- The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.
- Mosser S1, Alattia JR1, Dimitrov M1, Matz A1, Pascual J1, Schneider BL1, Fraering PC2.
- Human molecular genetics.Hum Mol Genet.2015 Jan 15;24(2):371-82. doi: 10.1093/hmg/ddu449. Epub 2014 Sep 1.
- The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an intramembrane-cleaving protease with multiple substrat
- PMID 25180020
- A Protease-Independent Function for SPPL3 in NFAT Activation.
- Makowski SL1, Wang Z1, Pomerantz JL2.
- Molecular and cellular biology.Mol Cell Biol.2015 Jan 15;35(2):451-67. doi: 10.1128/MCB.01124-14. Epub 2014 Nov 10.
- The signal peptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group of polytopic membrane proteins, some of which function in innate or adaptive immunity by cleaving proteins involved in antigen presentation or intracellular signaling. Signal peptide peptidase-like 3 (
- PMID 25384971
- Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage.
- Takei N1, Sobu Y1, Kimura A1, Urano S1, Piao Y1, Araki Y1, Taru H1, Yamamoto T2, Hata S1, Nakaya T1, Suzuki T3.
- The Journal of biological chemistry.J Biol Chem.2015 Jan 9;290(2):987-95. doi: 10.1074/jbc.M114.599852. Epub 2014 Nov 18.
- The neural type I membrane protein Alcadein α (Alcα), is primarily cleaved by amyloid β-protein precursor (APP) α-secretase to generate a membrane-associated carboxyl-terminal fragment (Alcα CTF), which is further cleaved by γ-secretase to secrete p3-Alcα peptides and generate an intracellula
- PMID 25406318
Japanese Journal
- Alzheimer病予防・治療法におけるγセクレターゼ活性制御
- Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage.
- Hydrophilic microenvironment required for the channel-independent insertase function of YidC protein
Related Links
- Introduction Proteolysis, as the name indicated, refers to the cleavage of protein in the presence of water. However, a new concept of proteolysis was coined in the last two decades, that is, the Regulated Intramembrane ...
- SPring-8 利用者情報/2011年8月 198 最近の研究から intramembrane proteases. The breakthrough was finally made in 2006. Four independent groups successfully solved the structures of the bacterial homologs of Rhomboid in ...
★リンクテーブル★
[★]
- 英
- intramembrane、intramembranous
[★]
- 関
- intramembrane
[★]
制御的膜内切断、制限的膜内切断
- 関
- RIP