WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
inflammation of the ear

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
再発する;繰り返し起こる
mediumの複数形

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1. 小児における急性中耳炎：治療 acute otitis media in children treatment
2. 小児における急性中耳炎：再発予防 acute otitis media in children prevention of recurrence
3. 成人における急性中耳炎（化膿性および漿液性） acute otitis media in adults suppurative and serous
4. 小児における急性中耳炎：疫学、微生物学、臨床症状、および合併症 acute otitis media in children epidemiology microbiology clinical manifestations and complications
5. 慢性化膿性中耳炎（CSOM）：予防、治療、予後、および合併症 chronic suppurative otitis media csom prevention treatment prognosis and complications

Poor memory B cell generation contributes to non-protective responses to DTaP vaccine antigens in otitis-prone children.

Basha S1, Pichichero ME1.
Clinical and experimental immunology.Clin Exp Immunol.2015 Dec;182(3):314-22. doi: 10.1111/cei.12660. Epub 2015 Sep 30.
We recently identified a cohort of children with recurrent episodes of acute otitis media (AOM) who fail to generate protective antibody titres to otopathogens and several vaccine antigens. In this study we determined the antibody levels against DTaP vaccine antigens, diphtheria toxoid (DT), tetanus
PMID 26138025

Streptococcus salivarius 24SMB administered by nasal spray for the prevention of acute otitis media in otitis-prone children.

Marchisio P1, Santagati M2, Scillato M2, Baggi E1, Fattizzo M1, Rosazza C1, Stefani S2, Esposito S3, Principi N1.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.Eur J Clin Microbiol Infect Dis.2015 Dec;34(12):2377-83. doi: 10.1007/s10096-015-2491-x. Epub 2015 Sep 18.
This paper reports the results of the first study in which Streptococcus salivarius 24SMB, a safe α-haemolytic strain capable of producing bacteriocin-like substances with significant activity against acute otitis media (AOM) pathogens, was intranasally administered in an attempt to reduce the risk
PMID 26385346

Aarhus L1, Engdahl B1, Tambs K1, Kvestad E1, Hoffman HJ2.
JAMA otolaryngology-- head & neck surgery.JAMA Otolaryngol Head Neck Surg.2015 Nov 1;141(11):983-9. doi: 10.1001/jamaoto.2015.2378.
IMPORTANCE: The association between childhood hearing disorders and adult tinnitus has not been examined in longitudinal cohort studies.OBJECTIVES: To determine the association between different types of childhood hearing loss and tinnitus in adulthood and evaluate whether tinnitus risk is mediated
PMID 26540147