組換え顆粒球コロニー刺激因子

WordNet

a geographical area politically controlled by a distant country (同)dependency
a body of people who settle far from home but maintain ties with their homeland; inhabitants remain nationals of their home state but are not literally under the home states system of government; "the American colony in Paris" (同)settlement
(microbiology) a group of organisms grown from a single parent cell
a group of organisms of the same type living or growing together
a place where a group of people with the same interest or occupation are concentrated; "a nudist colony"; "an artists colony"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the basic unit of money in Costa Rica; equal to 100 centimos (同)Costa Rican colon
the basic unit of money in El Salvador; equal to 100 centavos (同)El Salvadoran colon
a punctuation mark (:) used after a word introducing a series or an example or an explanation (or after the salutation of a business letter)
the part of the large intestine between the cecum and the rectum; it extracts moisture from food residues before they are excreted
of or relating to recombinant DNA
a cell or organism in which genetic recombination has occurred

PrepTutorEJDIC

『植民地』 / 植民団,居留民;(外国人の)集団居留地 / (同ど人種・宗教・職業などの人たちが住む)『集団』,部落 / (動物・鳥・虫などの)集団;(生物の)群体,群落《+『of』+『名』》 / 《the Colonies》アメリカ合衆国を形成した13州のイギリス植民地
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
コロン(:)(句読点の一種で,文中においてセミコロン以上を分離を示すほか,対照,例証,引用文などを示すのに用いる)
(大腸の)結腸[部]
遺伝子の新結合による

UpToDate Contents

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1. 化学療法による好中球減少症を有する成人患者と、急性白血病、骨髄異形成症候群、造血細胞移植以外の病態を有する成人患者における顆粒球コロニー刺激因子の利用 use of granulocyte colony stimulating factors in adult patients with chemotherapy induced neutropenia and conditions other than acute leukemia myelodysplastic syndrome and hematopoietic cell transplantation
2. 血小板産生因子の臨床応用 clinical applications of thrombopoietic growth factors
3. 造血細胞移植後の造血の促進 hematopoietic support after hematopoietic cell transplantation
4. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
5. 骨髄異形成症候群の合併症のマネージメント management of the complications of the myelodysplastic syndromes

English Journal

Synergetic Protein Factors That Improve rhGM-CSF Absorption via an Oral Route Exist in Silkworm Pupae.

Zhang W1, Wang J1, Zhang C1, Fang Q1, Shu J1, Li S1, Jin J1, Wang D1, Nie Z1, Lv Z1, Zhang Y1.
Molecular pharmaceutics.Mol Pharm.2015 May 4;12(5):1347-55. doi: 10.1021/mp500371g. Epub 2015 Mar 30.
Recent studies have demonstrated that recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) produced by the silkworm pupae bioreactor is absorbed into blood through oral administration and functions as an active cytokine. The aim of this study was to further examine and ident
PMID 25775407

rhCSF3 accelerates the proliferation of human melanocytes in culture through binding CSF3R and the expression of CSF3R transcripts.

Lu Y1, Guo Z, Zhou MH, Li X, Sun J, Gong QL, Zhu WY.
Archives of dermatological research.Arch Dermatol Res.2015 May;307(4):341-50. doi: 10.1007/s00403-015-1545-3. Epub 2015 Feb 10.
Melanogenic paracrine and autocrine cytokine networks have recently been discovered in vitro between melanocytes and other types of skin cells. Granulocyte colony-stimulating factor receptor (CSF3R) controls the survival, proliferation and differentiation of many kinds of cells, including neutrophil
PMID 25666388

First-in-human, phase I/IIa dose-escalation and safety study of balugrastim in breast cancer patients receiving myelosuppressive chemotherapy.

Avisar N1, Adar L, Bock J, Müller U, Shen D, Barash S, Pukac L.
Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2015 May;75(5):929-39. doi: 10.1007/s00280-015-2703-1. Epub 2015 Mar 5.
PURPOSE: To evaluate safety of balugrastim, a recombinant human serum albumin and granulocyte colony-stimulating factor (G-CSF), administered over a range of therapeutic doses in women with breast cancer receiving doxorubicin plus docetaxel chemotherapy.METHODS: The phase I, sequential dose-escalati
PMID 25740691

Japanese Journal

In Vivo Pharmacokinetics and Pharmacodynamics of Positional Isomers of Mono-PEGylated Recombinant Human Granulocyte Colony Stimulating Factor in Rats

Kang Jung Seok,Lee Kang Choon
Biological & pharmaceutical bulletin 36(7), 1146-1151, 2013-07
NAID 40019678319

Enhancing toxic protein expression in Escherichia coli fed-batch culture using kinetic parameters : Human granulocyte-macrophage colony-stimulating factor as a model system(BIOCHEMICAL ENGINEERING)

Khasa Yogender Pal,Khushoo Amardeep,Mukherjee Krishna Jyoti
Journal of bioscience and bioengineering 115(3), 291-297, 2013-03
… The kinetics of recombinant human granulocyte-macrophage colony-stimulating factor (hGM-CSF) expression was studied under the strong T7 promoter in continuous culture of Escherichia coli using complex medium to design an optimum feeding strategy for high cell density cultivation. … Recombinant protein expression was in the form of inclusion bodies with a maximum specific product formation rate (q_p) of 63.5 mg g^<-1> …
NAID 110009596103

In Vivo Pharmacokinetics and Pharmacodynamics of Positional Isomers of Mono-PEGylated Recombinant Human Granulocyte Colony Stimulating Factor in Rats

Kang Jung Seok,Lee Kang Choon
Biological and Pharmaceutical Bulletin 36(7), 1146-1151, 2013
… In this study, the pharmacokinetic and pharmacodynamic properties of Lys35, MetN-terminal, and Lys17-mono-PEGylated recombinant human granulocyte colony stimulating factor (rhG-CSF) positional isomers were evaluated in rats. …
NAID 130003361475