WordNet
- used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
- a negative; "his no was loud and clear"
- referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
- not in any degree or manner; not at all; "he is no better today"
- quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
- sway gently back and forth, as in a nodding motion; "the flowers were nodding in the breeze"
- be almost asleep; "The old man sat nodding by the fireplace"
- let the head fall forward through drowsiness; "The old man was nodding in his chair"
- the act of nodding the head
- a sign of assent or salutation or command
- express or signify by nodding; "He nodded his approval"
- lower and raise the head, as to indicate assent or agreement or confirmation; "The teacher nodded when the student gave the right answer"
- any thickened enlargement (同)knob, thickening
- (botany) the small swelling that is the part of a plant stem from which one or more leaves emerge (同)leaf node
- a connecting point at which several lines come together
- (computer science) any computer that is hooked up to a computer network (同)client, guest
- (astronomy) a point where an orbit crosses a plane
- (physics) the point of minimum displacement in a periodic system
- any bulge or swelling of an anatomical structure or part
- used of preliterate or tribal or nonindustrial societies; "primitive societies"
- a person who belongs to an early stage of civilization (同)primitive person
- a mathematical expression from which another expression is derived
- a word serving as the basis for inflected or derived forms; "`pick is the primitive from which `picket is derived"
- of or created by one without formal training; simple or naive in style; "primitive art such as that by Grandma Moses is often colorful and striking" (同)naive
PrepTutorEJDIC
- 《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
- (承諾・あいさつ・合図などで)『うなずく』,会釈する / (眠くて)『こっくりする』,(油断して)うとうとする《+off》 / 〈草木・穂などが〉揺れる / (承諾・あいさつなどで)〈頭〉‘を'『うなずかせる』 / …‘を'うなずいて示す / 《副詞[句]を伴って》〈人〉‘に'うなずいて示す / 《同意・承諾・あいさつ・命令など,また時には拒絶を表して》(…に対する)『うなずき』,『会釈』《+『to』+『名』》;(眠気による)こっくり
- (茎・幹の)節(ふし) / (体組織にできた)結節,こぶ(リンパ瘤(りゅう)など) / (天体の軌道の)交点 / (物事の)中心点
- 『原始の』,太古の / 原始的な,そぼくな;古風な,旧式な / 原始人
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/27 14:04:21」(JST)
[Wiki en表示]
Primitive knot |
Details |
Latin |
nodus primitivus |
Days |
17 |
Gray's |
p.47 |
Dorlands
/Elsevier |
k_04/12471954 |
Anatomical terminology |
The primitive knot (or primitive node) is the organizer for gastrulation in vertebrates.
Contents
- 1 Diversity
- 2 Development
- 3 Default model
- 4 References
- 5 External links
Diversity
- In birds, it is known as "Hensen's node", and is named after its discoverer Victor Hensen.
- In amphibians, it is known as "Spemann's organizer", and is named after Hans Spemann (who, with Mangold, first identified the organizer in 1924.[1])
Development
In chick development, the primitive knot starts as a regional knot of cells that forms on the blastodisc immediately anterior to where the outer layer of cells will begin to migrate inwards - an area known as the primitive streak, which is involved with Koller's sickle. Posterior to the node is the primitive pit, where the cells of the epiblast (the upper layer of embryonic cells) initially begin to invaginate. This invagination expands posteriorly into the primitive groove as the cells layers continue to move into the space between the embryonic cells and the yolk. This differentiates the embryo into the germ layers - endoderm, mesoderm, and ectoderm. The primitive knot migrates posteriorly as gastrulation proceeds, eventually being absorbed into the tail bud.
Default model
The cells of the primitive node secrete many cellular signals essential for neural differentiation. After gastrulation the developing embryo is divided into ectoderm, mesoderm, and endoderm. The ectoderm gives rise to epithelial and neural tissue, with neural tissue being the default cell fate. Bone morphogenetic proteins (BMPs) suppress neural differentiation and promote epithelial growth. Therefore, the primitive node (the dorsal lip of the blastopore) secretes BMP antagonists, including noggin, chordin, and follistatin.
References
- ^ Garcia-Fernàndez J, D'Aniello S, Escrivà H (2007). "Organizing chordates with an organizer". Bioessays 29 (7): 619–24. doi:10.1002/bies.20596. PMID 17563072.
External links
- Overview at nature.com
- Overview at Northwestern University
- Embryonic Organizers at the US National Library of Medicine Medical Subject Headings (MeSH)
Human embryogenesis in the first three weeks
|
|
Week 1 |
- Fertilization
- Oocyte activation
- Zygote
- Cleavage
- Blastomere
- Morula
- Blastocoele
- Blastocyst
- Blastula
- Inner cell mass
|
|
Week 2
(Bilaminar) |
|
|
Week 3
(Trilaminar) |
Germ layers |
- Archenteron/Primitive streak
- Primitive pit
- Primitive knot/Blastopore
- Primitive groove
- Gastrula
- Regional specification
- Embryonic disc
|
|
Ectoderm |
- Surface ectoderm
- Neuroectoderm
- Somatopleuric mesenchyme
- Neurulation
- Neural crest
|
|
Endoderm |
- Splanchnopleuric mesenchyme
|
|
Mesoderm |
- Axial mesoderm
- Paraxial
- Intermediate
- Lateral plate
- Intraembryonic coelom
- Splanchnopleuric mesenchyme
- Somatopleuric mesenchyme
|
|
|
Index of developmental medicine
|
|
Description |
- Embryology
- Cell lines
- endoderm
- mesoderm
- ectoderm
|
|
Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
|
|
|
UpToDate Contents
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English Journal
- Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.
- Shukla N1, Somwar R2, Smith RS3, Ambati S4, Munoz S2, Merchant M4, D'Arcy P5, Wang X5, Kobos R4, Antczak C6, Bhinder B6, Shum D6, Radu C6, Yang G7, Taylor BS8, Ng CK3, Weigelt B3, Khodos I9, de Stanchina E9, Reis-Filho JS3, Ouerfelli O7, Linder S10, Djaballah H6, Ladanyi M11.
- Cancer research.Cancer Res.2016 Aug 1;76(15):4525-34. doi: 10.1158/0008-5472.CAN-16-1040. Epub 2016 Jun 2.
- Ewing sarcoma is a primitive round cell sarcoma with a peak incidence in adolescence that is driven by a chimeric oncogene created from the fusion of the EWSR1 gene with a member of the ETS family of genes. Patients with metastatic and recurrent disease have dismal outcomes and need better therapeut
- PMID 27256563
- (18)F-FDG PET/CT, cytoreductive surgery and intraperitoneal chemohyperthermia for the therapeutic management in peritoneal carcinomatosis: A pilot study.
- Cistaro A1, Cucinotta M2, Cassalia L2, Priola A3, Priola S3, Pappalardo M4, Coppolino P2, De Simone M5, Quartuccio N6.
- Revista española de medicina nuclear e imagen molecular.Rev Esp Med Nucl Imagen Mol.2016 Jul-Aug;35(4):232-7. doi: 10.1016/j.remn.2016.01.001. Epub 2016 Feb 19.
- AIM: Peritoneal carcinomatosis is a common evolution of neoplasms and the terminal stage of disease. A new therapeutic technique, based on the total surgical removal of peritoneal lesions (peritonectomy procedure - PP) combined with the intraperitoneal chemohyperthermia (IPCH), has been developed. P
- PMID 26907833
- Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node.
- Ducharne-Asuaje E1, Dorion D2, Lamarre L3, Coindre JM4, Geha S5.
- Head and neck pathology.Head Neck Pathol.2016 Jun;10(2):225-8. doi: 10.1007/s12105-015-0631-3. Epub 2015 May 1.
- Head and neck angiosarcoma is an infrequent malignant vascular tumor most commonly found in the skin and soft tissue of the head and neck. Most head and neck angiosarcomas are metastatic to cervical lymph nodes from other primitive location. We describe herein a case of primary high-grade poorly dif
- PMID 25930154
Japanese Journal
- 辻村 隆司,土師 知行,佐藤 進一 [他],田村 哲也,市丸 和之,南 和彦,山田 光一郎,上田 俊雄,藤 さやか,坂本 進
- 耳鼻咽喉科臨床 104(4), 255-260, 2011-04-01
- … The diagnosis was primitive neuroectodermal tumor. … She died of multiple lymph node, lung, liver, and bone metastasis. …
- NAID 10027972335
- 早期再発にもかかわらず長期に生存している未分化神経外胚葉性腫瘍(PNET)の1例
- 中村 誠,犬飼 岳史,赤羽 弘資,黒田 格,宇野 佳奈子,根本 篤,合井 久美子,毛利 成昭,蓮田 憲夫,高野 邦夫,大西 洋,杉田 完爾
- 小児がん : 小児悪性腫瘍研究会記録 48(1), 12-16, 2011-02-25
- 症例は初発時に10歳の男児で,左腰部の皮下組織を原発とする未分化神経外胚葉性腫瘍に対して,外科療法と放射線療法および自家末梢血幹細胞移植を併用した大量化学療法を施行したが,治療開始から22か月後に左鎖骨上窩のリンパ節に再発した.切除断端に腫瘍細胞が陽性であり,40Gyの局所照射と3クールのイリノテカンの投与を含む計4クールの化学療法を行った.治療終了から81か月を経過して再々発なく生存中である.
- NAID 110008608574
Related Links
- Watch the introductory video to learn more about our database of embryonic development for stem cell research and regenerative medicine × ... The primitive node is an area through which migrating cells are channelled into a rodlike ...
- prim·i·tive node a local thickening of the epiblast at the cephalic end of the primitive streak of the embryo (the node is an embryonic organizer). Synonym(s): Hensen knot, Hensen node, Hubrecht protochordal knot, primitive knot, protochordal knot
Related Pictures
★リンクテーブル★
[★]
- 英
- primitive node, primitive knot
- ラ
- nodus primitivus
- 同
- ヘンゼン結節 Hensen node、原結節
- 関
- 原始間葉
- Goosecoid, Chordin, Noggin, Follistatinを発現、分泌してBMP4を抑制
- 神経の融合(外胚葉に対して)や背腹軸の決定(中胚葉に対して)に関わる
[★]
- 関
- clause、ganglia、ganglion、ganglionic、knot、lymph node、nodal、nodose、nodulate、section、tubercle、tubercular、tuberosity
[★]
- 関
- primitively
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