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1. 心電図チュートリアル：洞結節での調律および不整脈ecg tutorial rhythms and arrhythmias of the sinus node [show details]
…of the impulse through the atrioventricular node and a shortening of the PR interval. Sinus node dysfunction results from intrinsic disease of the sinus node. Some individuals with this syndrome also …
2. 洞結節機能不全：疫学、病因、自然経過sinus node dysfunction epidemiology etiology and natural history [show details]
… move among groups of cells within the region of the SA node, only about 1 percent of the cells in the SA node act as the leading pacemaker . Sinus node dysfunction (SND), also historically referred to as …
3. 乳癌におけるセンチネルリンパ節生検の概要overview of sentinel lymph node biopsy in breast cancer [show details]
… axillary lymph nodes is one of the most important prognostic factors in patients with breast cancer. Histologic examination of lymph nodes is the most accurate method for assessing lymph node metastasis. …
4. 前立腺癌：病理組織学的病期T3の癌、切除断端陽性、前立腺全摘除術後のリンパ節転移prostate cancer pathologic stage t3 disease positive surgical margins and lymph node involvement following radical prostatectomy [show details]
…the surgical specimen (R1), or lymph node involvement . The management of patients with pT3/T4 disease, positive surgical margins, or pathologic lymph node involvement following radical prostatectomy …
5. 中リスク、高リスク、超高リスクの限局性前立腺癌と臨床的に明らかなリンパ節転移陽性前立腺癌患者の初期管理initial management of regionally localized intermediate high and very high risk prostate cancer and those with clinical lymph node involvement [show details]
…generally recommended for men with clinically node-positive disease. Pelvic lymph node dissection is the only accurate means of assessing pelvic lymph node involvement and is generally performed in conjunction …

English Journal

Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation.

Paulsen J, Liyakat Ali TM, Nekrasov M, Delbarre E, Baudement MO, Kurscheid S, Tremethick D, Collas P.
Nature genetics. 2019 May;51(5)835-843.
Genomic information is selectively used to direct spatial and temporal gene expression during differentiation. Interactions between topologically associating domains (TADs) and between chromatin and the nuclear lamina organize and position chromosomes in the nucleus. However, how these genomic organ
PMID 31011212

The role of agrin, Lrp4 and MuSK during dendritic arborization and synaptogenesis in cultured embryonic CNS neurons.

Handara G, Hetsch FJA, Jüttner R, Schick A, Haupt C, Rathjen FG, Kröger S.
Developmental biology. 2019 01;445(1)54-67.
The role of agrin, Lrp4 and MuSK, key organizers of neuromuscular synaptogenesis, in the developing CNS is only poorly understood. We investigated the role of these proteins in cultured mouse embryonic cortical neurons from wildtype and from Lrp4- and MuSK-deficient mice. Neurons from Lrp4-deficient
PMID 30385274

WDR5 regulates left-right patterning via chromatin-dependent and -independent functions.

Kulkarni SS, Khokha MK.
Development (Cambridge, England). 2018 11;145(23).
Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, yet the genetic causes and mechanisms remain opaque. In a patient with CHD and heterotaxy, a disorder of left-right (LR) patterning, a mutation was identified in the chromatin modifier gene WDR5 acts as a scaffoldin
PMID 30377171