WordNet
- of first rank or importance or value; direct and immediate rather than secondary; "primary goals"; "a primary effect"; "primary sources"; "a primary interest"
- a preliminary election where delegates or nominees are chosen (同)primary_election
- one of the main flight feathers projecting along the outer edge of a birds wing (同)primary feather, primary quill
- (astronomy) a celestial body (especially a star) relative to other objects in orbit around it
- not derived from or reducible to something else; basic; "a primary instinct"
PrepTutorEJDIC
- 『第一の』,『主要な』 / 『初期の』,『初等の』,初級の / 『根本的な』,基本的な,本来の,直接的な / 《名詞の前にのみ用いて》(回路・コイル・巻き・電流などが)一次の / 原色(三原色の一つ) / 《米》=primary election
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- 1. 食道由来の胸痛 chest pain of esophageal origin
- 2. 逆流性食道炎の病態生理 pathophysiology of reflux esophagitis
- 3. 成人における難治性胃食道逆流症へのアプローチ approach to refractory gastroesophageal reflux disease in adults
- 4. 慢性連日性頭痛の概要 overview of chronic daily headache
- 5. 常染色体優性多発性嚢胞腎における疼痛症候群 pain syndromes in autosomal dominant polycystic kidney disease
English Journal
- Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation.
- Prado FC, Araldi D, Vieira AS, Oliveira-Fusaro MC, Tambeli CH, Parada CA.SourceDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas - UNICAMP, Brazil.
- Neuropharmacology.Neuropharmacology.2013 Apr;67:252-8. doi: 10.1016/j.neuropharm.2012.11.011. Epub 2012 Nov 24.
- We have demonstrated that the activation of P2X3 receptor on peripheral afferent neurons is critical to development of inflammatory hyperalgesia in peripheral tissue, although pharmacological administration of prostaglandin E(2) or sympathomimetic amines is enough to sensitize primary afferent neuro
- PMID 23186588
- Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice.
- Luongo L, Guida F, Boccella S, Bellini G, Gatta L, Rossi F, de Novellis V, Maione S.SourceDepartment of Experimental Medicine, Pharmacology Division, The Second University of Naples, via Costantinopoli 16, 80138 Naples, Italy. sabatino.maione@unina2.it.
- CNS & neurological disorders drug targets.CNS Neurol Disord Drug Targets.2013 Feb 4. [Epub ahead of print]
- Palmitoylethanolamide (PEA) is an endogenous cannabinoid-like compound in the central nervous system, which can modulate several functions in different pathological states, such as inflammation and pain response. We have here investigated the effect of PEA (5-10 mg/kg, intraperitoneally) on mech
- PMID 23394524
- Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia.
- Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA.Source*Department of Anesthesiology, †Department of Chemistry and Biochemistry, and ‡Department of Pharmacology, University of California-San Diego, La Jolla, California, USA.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2013 Feb 4. [Epub ahead of print]
- Previously, we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilins, which contribute to peripheral inflammation-induced tactile allodynia. However, the enzymatic sources of hepoxilin synthase (HXS) activity in rats remain elusive. Therefore, we overe
- PMID 23382512
Japanese Journal
- 培養ラット脊髄神経細胞における高濃度ブドウ糖によるニューロキニン１受容体の発現亢進
- 石関 哉生,安孫子 亜津子,伊藤 博史,平野 史倫,滝山 由美,羽田 勝計
- 旭川医科大学研究フォーラム 13(1), 38-49, 2013-02
- … 雑誌掲載版Hyperalgesia is one of the symptoms of diabetic neuropathy, particularly in the early stages of diabetic neuropathy. … The activation of neurokinin1 (NK1) receptors in the spinal cord by substance P results in thermal and mechanical hyperalgesia. … We used primary cultures of neonatal rat spinal neurons to elucidate whether NK1 receptor expression is regulated by glucose. …
- NAID 120005229820
- Roles of Glia, Immune Cells and the Thermo-TRP Channels, TRPV1, TRPA1 and TRPM8, in Pathological Pain
- 樋浦 明夫,中川 弘,Hiura Akio,Nakagawa Hiroshi
- The Open Neuroscience Journal 6, 10-26, 2012
- … Numerous experimental studies have showed the release of cytokines and inflammatory neuropeptides from peripheral and central terminals of primary sensory neurons and from ac-tivated peripheral and central glia after nerve injury (crush, ligation or transection), which in turn act in a paracrine or autocrine manner. …
- NAID 120004059003
- Involvement of NGF in the Rat Model of Persistent Muscle Pain Associated With Taut Band
- Li Jun,Yi Shuang-Qin,Wang Heng-Xiao,Yi Nozomi,Ogawa Yuki,Ozaki Noriyuki,Itoh Masahiro
- Journal of Pain 12(10), 1059-1068, 2011-10
- … Administration of NGF receptor (TrkA) inhibitor K252a showed significant suppression of mechanical hyperalgesia in EC animals. … Repeated EC induced persistent mechanical muscle hyperalgesia associated with TB. … NGF expressed in regenerating muscle cells may have an important role in persistent mechanical muscle hyperalgesia which might be relevant to pathogenesis of MPS. …
- NAID 120003221539
Related Links
- primary hyperalgesia increased sensation due to release of inflammatory mediators into peripheral tissues, subsequent to injury/infection; abnormally prolonged ... In an animal model of mild hindpaw thermal injury, primary ...
- Definition Hyperalgesia means increased sensitivity to painful or to normally non-painful stimulation. There are two definitions of “primary” and “secondary” hyperalgesia. (1) According to one definition, a hyperalgesia is primary if it ...
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★リンクテーブル★
| リンク元 | 「thermal hyperalgesia」「secondary hyperalgesia」「一次性痛覚過敏」 |
| 関連記事 | 「primary」「hyperalgesia」 |
「thermal hyperalgesia」
「secondary hyperalgesia」
「一次性痛覚過敏」
「primary」
- adj.
- 一次の、第一次の、主要な、(化学)第一級の、一級の、初生の、(病名)原発性の、原発の、プライマリーの
「hyperalgesia」
- 同
- hyperalgia