WordNet
- of or relating to a hot spring; "thermal water"
- rising current of warm air
- relating to or associated with heat; "thermal movements of molecules"; "thermal capacity"; "thermic energy"; "the caloric effect of sunlight" (同)thermic, caloric
- caused by or designed to retain heat; "a thermal burn"; "thermal underwear"
- a unit of heat equal to 100,000 British thermal units
PrepTutorEJDIC
- 熱の,熱による / 熱い / (暖まった)上昇気流
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- 1. 成人における難治性胃食道逆流症へのアプローチ approach to refractory gastroesophageal reflux disease in adults
- 2. 食道由来の胸痛 chest pain of esophageal origin
- 3. 心臓症候群X：正常冠動脈の狭心症：病因 cardiac syndrome x angina pectoris with normal coronary arteries pathogenesis
- 4. 過敏性腸症候群の病態生理 pathophysiology of irritable bowel syndrome
- 5. オピオイド系薬剤を用いた癌疼痛の管理：副作用の予防および管理 cancer pain management with opioids prevention and management of side effects
English Journal
- S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
- Gris G1, Merlos M, Vela JM, Zamanillo D, Portillo-Salido E.Author information 1Drug Discovery and Preclinical Development, Esteve, Parc Científic de Barcelona, Barcelona, Spain.AbstractThe therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and mechanical stimulation following an intraplantar injection of carrageenan (CARR) and complete Freund's adjuvant (CFA), which are two well-characterized models of acute and chronic inflammatory pain, respectively. S1RA fully reversed both mechanical [dose of drug that produced half of its maximal response (ED50)=35.9 and 42.1 mg/kg for CARR-induced and CFA-induced pain, respectively] and thermal (ED50=27.9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy. Morphine also showed maximum efficacy in all tests. Unlike celecoxib and ibuprofen, which decreased paw volume significantly, CARR-induced paw oedema was not reduced by S1RA and morphine, thus suggesting that the antinociceptive effect of S1RA does not involve a major anti-inflammatory (antioedema) action. S1RA was devoid of efficacy when administered to σ1R knockout mice, thus suggesting the involvement of σ1R in the antinociceptive effects exerted by S1RA. We conclude that S1RA represents a promising novel analgesic therapy for inflammatory pain.
- Behavioural pharmacology.Behav Pharmacol.2014 Jun;25(3):226-35. doi: 10.1097/FBP.0000000000000038.
- The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal res
- PMID 24776490
- A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia.
- Fowler M1, Clifford JL1, Garza TH1, Slater TM1, Arizpe HM1, Novak J2, Petz LN1, Loyd DR3.Author information 1Pain Management Research Area, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA, Fort Sam Houston, TX 78234, United States.2Veterinary Pathology, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA, Fort Sam Houston, TX 78234, United States.3Pain Management Research Area, United States Army Institute of Surgical Research, 3698 Chambers Pass, JBSA, Fort Sam Houston, TX 78234, United States. Electronic address: dayna.l.averitt.civ@mail.mil.AbstractOpioid-related side effects are problematic for burn patients. Dual mechanism therapeutics targeting opioid and non-opioid mechanisms may have reduced side effects with similar analgesic efficacy. Tramadol combines mu opioid receptor agonism with norepinephrine reuptake inhibition and has been effective in treating some types of pain. The effectiveness of tramadol in treating pain associated with burns is unclear. We hypothesized that tramadol is effective in reducing thermal injury-evoked pain behaviors in a rat model. Rats were anesthetized and a 100°C metal probe was placed on the hindpaw for 30s to induce a full thickness thermal injury. A subset of rats was perfusion fixed and hindpaw tissue and spinal cord collected for anatomical analysis. Rats received morphine (5mg/kg; i.p.), tramadol (10-30mg/kg; i.p.) or vehicle and latency to paw withdrawal from a noxious thermal or non-noxious mechanical stimulus was recorded every 10min over 70min and again at 2h. We report that pain behaviors developed within 48h and peaked at 1 week; paralleled by enhanced expression of pronociceptive neuropeptides in the spinal cord. Morphine and tramadol significantly attenuated hyperalgesia and allodynia, while not significantly altering motor coordination/sedation. These data indicate dual mechanism therapeutics may be effective for treating pain associated with burns.
- Burns : journal of the International Society for Burn Injuries.Burns.2014 Jun;40(4):759-71. doi: 10.1016/j.burns.2013.10.011. Epub 2013 Nov 26.
- Opioid-related side effects are problematic for burn patients. Dual mechanism therapeutics targeting opioid and non-opioid mechanisms may have reduced side effects with similar analgesic efficacy. Tramadol combines mu opioid receptor agonism with norepinephrine reuptake inhibition and has been effec
- PMID 24290856
- Effects of tramadol on viscero-visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis.
- Lopopolo M1, Affaitati G, Fabrizio A, Massimini F, Lapenna D, Giamberardino MA, Costantini R.Author information 1Pathophysiology of Pain Laboratory, Ce.S.I, "G. D'Annunzio" Foundation, via dei Vestini s.n., 66013, Chieti Scalo (Chieti), Italy; Department of Medicine and Science of Aging, University of Chieti, via dei Vestini s.n., 66013, Chieti Scalo (Chieti), Italy.AbstractThe effects of tramadol versus placebo administration on behavioral indicators of ureteral pain, pelvic pain and referred lumbar muscle hyperalgesia were investigated in a rat model of viscero-visceral hyperalgesia from endometriosis plus ureteral calculosis (endo + stone). Fifty female Sprague-Dawley rats underwent surgical induction of endometriosis and, 2 weeks later, were randomly assigned to five groups (10 each), to be treated i.p., twice a day, with tramadol (0.625, 1.25, 2.5, or 5 mg/kg) or saline for 5 days (14-18th day postendometriosis; prestone treatment). On the 21st day, they underwent laparotomy for stone formation in the upper left ureter (dental cement injection). All were video-taped 24 h nonstop for 7 days before and 4 days after stone formation (14-25th day postendometriosis) to record ureteral and pelvic pain behaviors. Lumbar sensitivity (L1) was tested bilaterally, daily over the same period, by verifying presence/absence of vocalization upon muscle pinching at a predefined pressure (calibrated forceps). Additional fifty endo + stone rats underwent the same protocol, except that treatment was performed on 21st-25th day (poststone treatment). Tramadol vs. saline significantly reduced number and duration of ureteral crises, duration of pelvic behavior, and incidence of muscle hyperalgesia (P < 0.0001), with a dose-dependent effect. Prestone treatment was significantly more effective than poststone treatment for the 1.25 dose for all parameters and 2.5 dose for pelvic and muscle parameters (0.003 > P < 0.02). Tramadol, even at low doses, is thus highly protective against pain from 'viscero-visceral hyperalgesia' in endometriosis plus ureteral calculosis; it can represent a valid therapeutic approach in women with these comorbidities.
- Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2014 Jun;28(3):331-41. doi: 10.1111/fcp.12038. Epub 2013 Jun 21.
- The effects of tramadol versus placebo administration on behavioral indicators of ureteral pain, pelvic pain and referred lumbar muscle hyperalgesia were investigated in a rat model of viscero-visceral hyperalgesia from endometriosis plus ureteral calculosis (endo + stone). Fifty female Sprague-Dawl
- PMID 23786290
Japanese Journal
- Contribution of TRPV1 Receptor–Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model
- Yamamoto Shohei,Ohsawa Masahiro,Ono Hideki
- Journal of Pharmacological Sciences, 2012
- … Neuropathic pain induces allodynia and hyperalgesia. … In the spared nerve injury (SNI) model, marked mechanical hyperalgesia is manifested as prolongation of the duration of paw withdrawal after pin stimulation. … Since these after-discharges occurred through transient receptor potential (TRP) V1–positive fibers, these fibers could contribute to mechanical hyperalgesia. …
- NAID 130002507897
- Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury–Induced Neuropathic Pain Models
- Ma Lin,Nagai Jun,Sekino Yuki,Goto Yoshitaka,Nakahira Shinji,Ueda Hiroshi
- Journal of Pharmacological Sciences 119(3), 2012
- … Spinal application of A2 NTX also showed a potent suppression of thermal hyperalgesia and mechanical allodynia in the spinal cord injury–induced neuropathic pain model. …
- NAID 130001889290
- TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice.
- Haraguchi Kayo,Kawamoto Ai,Isami Kouichi,Maeda Sanae,Kusano Ayaka,Asakura Kayoko,Shirakawa Hisashi,Mori Yasuo,Nakagawa Takayuki,Kaneko Shuji
- The Journal of neuroscience : the official journal of the Society for Neuroscience 32(11), 3931-3941, 2012
- … While wild-type and TRPM2 knock-out mice showed no difference in their basal sensitivity to mechanical and thermal stimulation, nocifensive behaviors in the formalin test were reduced in TRPM2 knock-out mice. … In carrageenan-induced inflammatory pain and sciatic nerve injury-induced neuropathic pain models, mechanical allodynia and thermal hyperalgesia were attenuated in TRPM2 knock-out mice. …
- NAID 120003987901
Related Links
- 一次痛覚過敏 primary hyperalgesia =peripheral hyperalgesia =peripheral sensitization 3重反応が出現した部位では痛覚閾値が低下し、痛みが増強している。 熱刺激でも機械刺激でも起こる。 侵害受容器のsensitization、末梢性の ...
- FIG. 1. The changes made in the year 2008 by the IASP task force in defining “hyperalgesia” and “allodynia.” In A, the obsolete definitions are illustrated: pain in response to previously nonpainful stimuli was defined as “allodynia” (blue ...
Related Pictures
★リンクテーブル★
| リンク元 | 「primary hyperalgesia」「熱痛覚過敏」「secondary hyperalgesia」「温熱性痛覚過敏」 |
| 関連記事 | 「thermal」「hyperalgesia」 |
「primary hyperalgesia」
「熱痛覚過敏」
「secondary hyperalgesia」
「温熱性痛覚過敏」
「thermal」
- adj.
- 温熱性の、熱的な、サーマル
「hyperalgesia」
- 同
- hyperalgia