前駆Bリンパ芽球性白血病
WordNet
- the 2nd letter of the Roman alphabet (同)b
- the blood group whose red cells carry the B antigen (同)type_B, group B
- a substance from which another substance is formed (especially by a metabolic reaction)
- a person who goes before or announces the coming of another (同)forerunner
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
- an immature lymphocyte
PrepTutorEJDIC
- (…の)前朕,前触れ《+『of』+『名』》
- 白血病
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/04 16:53:38」(JST)
[Wiki en表示]
| Precursor B-cell lymphoblastic leukemia |
|
A Wright's stained bone marrow aspirate smear from a person with precursor B-cell acute lymphoblastic leukemia.
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| Classification and external resources |
| Specialty |
oncology |
| ICD-10 |
C83.5 |
| ICD-O |
M9836/3 |
| MeSH |
D015452 |
|
[edit on Wikidata]
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Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.
It consists of the following subtypes:[1]
- t(9;22)-BCR/ ABL
- t(v;11q23)-MLL rearrangement
- t(1;19)-E2A/PBX1
- t(12;21)-ETV/ CBFα
- t(17;19)-E2A-HLF
Molecular Mechanisms
One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.[2][3]
References
- ^ Randolph TR (2004). "Advances in acute lymphoblastic leukemia". Clin Lab Sci. 17 (4): 235–45. PMID 15559730.
- ^ Carotta S, Nutt SL (March 2008). "Losing B cell identity". BioEssays. 30 (3): 203–7. doi:10.1002/bies.20725. PMID 18293359.
- ^ Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. (February 2009). "A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study". Lancet Oncol. 10 (2): 125–34. doi:10.1016/S1470-2045(08)70339-5. PMC 2707020. PMID 19138562.
This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".
External links
- Precursor B-lymphoblastic leukemia entry in the public domain NCI Dictionary of Cancer Terms
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Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
|
|
B cell
(lymphoma,
leukemia)
(most CD19
|
By
development/
marker |
| TdT+ |
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
|
|
| CD5+ |
- naive B cell (CLL/SLL)
- mantle zone (Mantle cell)
|
|
| CD22+ |
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
|
|
| CD79a+ |
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicle center lymphoma)
- marginal zone/marginal zone B-cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
|
|
| RS (CD15+, CD30+) |
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
|
|
PCDs/PP
(CD38+/CD138+) |
- see immunoproliferative immunoglobulin disorders
|
|
|
| By infection |
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
|
|
| Cutaneous |
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicle center lymphoma
|
|
|
| T/NK |
T cell
(lymphoma,
leukemia)
(most CD3
|
By
development/
marker |
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
|
|
| Cutaneous |
| MF+variants |
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary disease
- Adult T-cell leukemia/lymphoma
|
|
| Non-MF |
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
- CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large-cell lymphoma
- Lymphomatoid papulosis type A
|
|
|
Other
peripheral |
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma not otherwise specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
|
|
| By infection |
- HTLV-1 (Adult T-cell leukemia/lymphoma)
|
|
|
NK cell/
(most CD56) |
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
|
|
| T or NK |
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
|
|
|
Lymphoid+
myeloid |
- Acute biphenotypic leukaemia
|
|
| Lymphocytosis |
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
|
|
|
| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
|
UpToDate Contents
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English Journal
- B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients.
- Li Y1, Gupta G2, Molofsky A1, Xie Y1, Shihabi N3, McCormick J4, Jaffe ES5.
- The American journal of surgical pathology.Am J Surg Pathol.2018 Feb;42(2):269-276. doi: 10.1097/PAS.0000000000000982.
- PMID 29112016
- Therapy-related myeloid neoplasm in an 18-year-old boy with B-lymphoblastic leukemia.
- Qing X1, Panosyan E2, Yue C3, Ji P3, Gotesman M2, French S3, Cai J4.
- Experimental and molecular pathology.Exp Mol Pathol.2017 Dec;103(3):263-266. doi: 10.1016/j.yexmp.2017.11.007. Epub 2017 Nov 16.
- PMID 29155023
- High efficacy and safety of low-dose CD19-directed CAR-T cell therapy in 51 refractory or relapsed B acute lymphoblastic leukemia patients.
- Pan J1, Yang JF1, Deng BP2, Zhao XJ3, Zhang X1, Lin YH1, Wu YN2, Deng ZL2, Zhang YL3, Liu SH3, Wu T4, Lu PH1, Lu DP4, Chang AH3, Tong CR1.
- Leukemia.Leukemia.2017 Dec;31(12):2587-2593. doi: 10.1038/leu.2017.145. Epub 2017 May 15.
- PMID 28490811
Japanese Journal
- 牛白血病ウイルス感染牛におけるリンパ系腫瘍の組織学的検討
- 萩原 晶代,斉藤 守弘,石川 義春,門田 耕一
- 日本獣医師会雑誌 67(3), 199-203, 2014
- … 織学的，免疫組織化学的に調べた．56例はCD20とCD79aが陽性の多形型B細胞性リンパ腫で，細胞学的には多形性と異型性を特徴としていた．そのうちCD5の免疫染色が可能な54例では，すべての症例が陽性を示した．1例では胎子の皮下組織にも多形型のリンパ腫を認め，母牛のリンパ腫からの転移によるものと考えられた．残りの3例は前駆Bリンパ芽球性白血病，リンパ形質細胞様リンパ腫，γδT細胞性リ …
- NAID 130004640755
- Lymphoid Neoplasms in Swine
- , , [他], ,
- Journal of Veterinary Medical Science 74(2), 149-154, 2012
- … Cases 1-3 were precursor B lymphoblastic leukemias, which occurred in three piglets from the same dam. … Cases 4 and 5 were diagnosed, respectively, as a precursor B lymphoblastic lymphoma and a thymic B cell lymphoma, because there were cytological differences between the lymphomas. …
- NAID 130001033059
- 臨床研究・症例報告 眼球突出で発症したB前駆型急性リンパ性白血病/非ホジキンリンパ腫の2例
★リンクテーブル★
[★]
- 英
- precursor B-lymphoblastic leukemia
[★]
- Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する
[★]
- 関
- progenitor
[★]
- 関
- lymphoblast
[★]
- 関
- lymphoblastic
[★]
リンパ芽球性白血病