WordNet

an immature lymphocyte

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/11/28 08:14:34」(JST)

wiki en

[Wiki en表示]

Lymphoblast

A lymphoblast is a modified naive lymphocyte with altered cell morphology. It occurs when the lymphocyte is activated by an antigen (from antigen-presenting cells) and increased in volume by nucleus and cytoplasm growth as well as new mRNA and protein synthesis. The lymphoblast then starts dividing two to four times every 24-hours for 3-5 days, with a single lymphoblast making approximately 1000 clones of its original naive lymphocyte, with each sharing the originally unique antigen specificity. Finally the dividing cells differentiate into effector cells, known as Plasma Cells (for B cells), Cytotoxic T cells, and Helper T cells.^[1]

Lymphoblasts can also refer to immature cells which typically differentiate to form mature lymphocytes.^[2] Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia (ALL), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood.

The size is between 10 and 20 μm.^[3]

Although commonly lymphoblast refers to a precursor cell in the maturation of leukocytes, the usage of this term is sometimes inconsistent. The Chronic Lymphocytic Leukemia Research Consortium defines a lymphoblast as "A lymphocyte that has become larger after being stimulated by an antigen. Lymphoblasts look like immature lymphocytes, and were once thought to be precursor cells.".^[4] Commonly, when speaking about leukemia, "blast" is used as an abbreviation for lymphoblasts.

Lymphoblasts can be distinguished microscopically from myeloblasts by having less distinct nucleoli, more condensed chromatin, and an absence of cytoplasmic granules. However these morphologic distinctions are not absolute and a definitive diagnoses relies on antibody immunostaining for the presence of unique cluster of differentiation receptors.^[5]

Additional images

Blood cell lineage

References

^ Janeway's Immunobiology, 9th edition, Chapter 1, page 23
^ Information, National Center for Biotechnology; Pike, U. S. National Library of Medicine 8600 Rockville; MD, Bethesda; Usa, 20894. "Lymphoblasts - National Library of Medicine". PubMed Health. Retrieved 2015-11-17.
^ Gillian Rozenberg (23 March 2011). Microscopic Haematology: A Practical Guide for the Laboratory. Elsevier Australia. pp. 106–. ISBN 978-0-7295-4072-8. Retrieved 29 May 2011.
^ CRC - Glossary L Archived 2006-02-11 at the Wayback Machine.
^ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon C. (2010). Robbins and Cotran Pathologic Basis of Disease. Philadelphia: Saunders. p. 602. ISBN 978-1-4160-3121-5. 8th edition.

This oncology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 前駆T細胞性急性リンパ芽球性白血病／リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of precursor t cell acute lymphoblastic leukemia lymphoma
2. Approach to the adult with lymphocytosis or lymphocytopenia
3. 小児および思春期における急性リンパ芽球性白血病のリスクグループ層別化および予後 risk group stratification and prognosis for acute lymphoblastic leukemia in children and adolescents
4. 前駆B細胞性急性リンパ芽球性白血病／リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of precursor b cell acute lymphoblastic leukemia lymphoma
5. 小児および思春期における急性リンパ芽球性白血病の治療の概要 overview of the treatment of acute lymphoblastic leukemia in children and adolescents

English Journal

Compromised mitochondrial complex II in models of Machado-Joseph disease.

Laço MN, Oliveira CR, Paulson HL, Rego AC.SourceCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Biochimica et biophysica acta.Biochim Biophys Acta.2012 Feb;1822(2):139-49. Epub 2011 Oct 20.
Machado-Joseph disease (MJD), also known as Spinocerebellar Ataxia type 3, is an inherited dominant autosomal neurodegenerative disorder. An expansion of Cytosine-Adenine-Guanine (CAG) repeats in the ATXN3 gene is translated as an expanded polyglutamine domain in the disease protein, ataxin-3. Selec
PMID 22037589

Crystal structure, electronic properties and cytotoxic activity of palladium chloride complexes with monosubstituted pyridines.

Krogul A, Cedrowski J, Wiktorska K, Ozimiński WP, Skupińska J, Litwinienko G.SourceUniversity of Warsaw, Pasteura 1, 02-093, Warsaw, Poland. litwin@chem.uw.edu.pl akrogul@chem.uw.edu.pl.
Dalton transactions (Cambridge, England : 2003).Dalton Trans.2012 Jan 14;41(2):658-66. Epub 2011 Nov 8.
Palladium(ii) complexes attract great attention due to their remarkable catalytic and biological activity. In the present study X-ray characterization, UV-Vis and Time-Dependent Density Functional Theory (TD-DFT) calculations for six PdCl(2)(XPy)(2) complexes (where: Py = pyridine; X = H, CH(3) or C
PMID 22068915

Japanese Journal

Excess processing of oxidative damaged bases causes hypersensitivity to oxidative stress and low dose rate irradiation.

Free radical research 49(10), 1239-1248, 2015-10
NAID 120005676680

Losartan Competitively Inhibits CYP2C8-Dependent Paclitaxel Metabolism <i>in Vitro</i>

Biological and Pharmaceutical Bulletin 37(9), 1550-1554, 2014
NAID 130004684797

臍帯血移植後に donor cell leukemia を発症して hematogones との鑑別を要した急性リンパ性白血病

臨床血液 54(5), 473-477, 2013-05-30
NAID 10031177974

Related Pictures

★リンクテーブル★

リンク元	「リンパ芽球」「lymphoblastic」「リンパ芽球細胞」
拡張検索	「large-cell lymphoblastic lymphoma」「lymphoblastic lymphoma」「acute lymphoblastic leukemia」