同: PFA-100

WordNet

perform as expected when applied; "The washing machine wont go unless its plugged in"; "Does this old car still run well?"; "This old radio doesnt work anymore" (同)work, operate, go, run
(mathematics) a mathematical relation such that each element of a given set (the domain of the function) is associated with an element of another set (the range of the function) (同)mathematical function, single-valued function, map, mapping
a relation such that one thing is dependent on another; "height is a function of age"; "price is a function of supply and demand"
the actions and activities assigned to or required or expected of a person or group; "the function of a teacher"; "the government must do its part"; "play its role" (同)office, part, role
what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?" (同)purpose, role, use
a formal or official social gathering or ceremony; "it was a black-tie function"
consider in detail and subject to an analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare"; "analyze the evidence in a criminal trial"; "analyze your real motives" (同)analyse, study, examine, canvass, canvas
break down into components or essential features; "analyze todays financial market" (同)analyse
make a mathematical, chemical, or grammatical analysis of; break down into components or essential features; "analyze a specimen"; "analyze a sentence"; "analyze a chemical compound" (同)analyse, break_down, dissect, take apart
subject to psychoanalytic treatment; "I was analyzed in Vienna by a famous psychiatrist" (同)analyse, psychoanalyze, psychoanalyse
tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte
an instrument that performs analyses (同)analyser
performing or able to perform its regular function; "a functioning flashlight"

PrepTutorEJDIC

(人・物の果たすべき)『働き』,機能,役目;《しばしば複数形で》職務 / (公式の)儀式,《話》大きな催し(集まり),式典 / (数学で)関数 / 〈機械などが〉『機能を果たす』,動く / (…の)役目をする,代用となる《+『as』+『名』》

UpToDate Contents

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1. 血小板機能検査 platelet function testing
2. 出血性素因を有する成人患者へのアプローチ approach to the adult patient with a bleeding diathesis
3. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
4. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms
5. von Willebrand病の臨床症状および診断 clinical presentation and diagnosis of von willebrand disease

English Journal

Aspirin resistance in patients with type II diabetes mellitus.

Tasdemir E, Toptas T, Demir C, Esen R, Atmaca M.Author information Department of Internal Medicine, Van Training and Research Hospital , Van , Turkey.AbstractAbstract Background. Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients. Material and methods. A total of 93 diabetic and 37 non-diabetic participants were included into the study. Aspirin resistance was measured with a whole-blood desktop platelet function analyzer (PFA-100) with an epinephrine agonist. Results. Altogether 41.9% patients with DM were aspirin non-responders. Aspirin resistance was observed in 43.2% of non-diabetic patients (p = 0.89). Presence of diabetes mellitus had no effect on aspirin response (RR 0.95 (95% CI 0.44-2.05), p = 0.89) in the whole study population. Hypercholesterolemia was the only predictor of aspirin resistance in multivariate analysis in diabetic patients (RR 3.09 (95% CI 1.17-8.16), p = 0.023). Conclusion. The prevalence of aspirin resistance is comparable in diabetic and non-diabetic patients. Hypercholesterolemia is the only independent predictor of aspirin resistance in diabetic patients.
Upsala journal of medical sciences.Ups J Med Sci.2014 Mar;119(1):25-31. doi: 10.3109/03009734.2013.861549. Epub 2013 Nov 18.
Abstract Background. Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients. Material and methods. A total of 93 diabetic and 37 non-diabetic parti
PMID 24236750

External Quality Assessment/Proficiency Testing and Internal Quality Control for the PFA-100 and PFA-200: An Update.

Favaloro EJ1, Bonar R2.Author information 1Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, Westmead Hospital, New South Wales, Australia.2Royal College of Pathologists of Australasia Quality Assurance Program Haematology, St Leonards, New South Wales, Australia.AbstractPlatelet function testing is an essential component of comprehensive hemostasis evaluation within the framework of bleeding and/or bruising investigations, and it may also be performed to evaluate antiplatelet medication effects. Globally, the platelet function analyzer (PFA)-100 (Siemens Healthcare, Marburg, Germany) is the most used primary hemostasis-screening instrument and has also been recently remodeled/upgraded to the PFA-200. The PFA-100 is sensitive to a wide range of associated disorders, including platelet function defects and von Willebrand disease (VWD), as well as to various antiplatelet medications. The PFA-100 is also useful in therapy monitoring, especially in VWD. External quality assessment (EQA) (or proficiency testing) and internal quality control (IQC) are critical to ensuring quality of test practice, inclusive of all hemostasis tests. However, both EQA and IQC for platelet function testing, including the PFA-100, is logistically challenging, given theoretical requirements for production, storage, and shipment of large volumes of "stabilized" normal and pathological blood/platelets covering both normal function plus a wide variety of potential defects. We accordingly describe the development and testing of novel feasible approaches to both EQA and IQC of PFA-100/PFA-200 instruments, whereby a range of formulated "platelet function antagonist" materials are utilized. For EQA purposes, these are distributed to participants, and citrated normal whole blood collected on site is then added locally, thereby creating test material that can be locally evaluated. Several exercises have been conducted by the Royal College of Pathologists of Australasia Quality Assurance Program (RCPAQAP) over the past 6 years. A total of 26 challenges, with most designed to mimic moderate to severe primary hemostasis defects, have been tested in 26 to 50 laboratories depending on the year of dispatch. Numerical results for PFA-100/PFA-200 closure times (CTs) and interpretive comments supplied by participants are analyzed by the RCPAQAP. During this period, reported CTs for each challenge were within limits of expectation and good reproducibility was evidenced by repeated challenges. Coefficients of variation (CVs) generated for challenges using the two major PFA-100/PFA-200 cartridge types (collagen/adenosine diphosphate and collagen/epinephrine) are always similar to those obtained using native whole blood, and in general range from 15 to 25%. Interpretations are also in general consistent with expectations and test data provided by laboratories. The EQA created material has also been assessed within the context of possible IQC material. In conclusion, EQA and IQC processes for the PFA-100/PFA-200 have been developed that include highly reproducible test challenge processes, not only supporting the concept that EQA/IQC is possible for platelet function testing but also providing a valuable mechanism for monitoring and improving laboratory performance in this area.
Seminars in thrombosis and hemostasis.Semin Thromb Hemost.2014 Feb 4. [Epub ahead of print]
Platelet function testing is an essential component of comprehensive hemostasis evaluation within the framework of bleeding and/or bruising investigations, and it may also be performed to evaluate antiplatelet medication effects. Globally, the platelet function analyzer (PFA)-100 (Siemens Healthcare
PMID 24497116

Usefulness of the INNOVANCE® PFA P2Y test cartridge for the detection of patients with congenital defects of the platelet P2Y12 receptor for adenosine diphosphate.

Scavone M1, Germanovich K1, Femia EA1, Cattaneo M2.Author information 1Divisione di Medicina 3, Ospedale San Paolo - Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy.2Divisione di Medicina 3, Ospedale San Paolo - Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy. Electronic address: marco.cattaneo@unimi.it.AbstractINTRODUCTION: The platelet function analyzer (PFA)-100® is used in clinical practice to screen patients with bleeding diathesis and suspected defects of primary hemostasis. A new cartridge, INNOVANCE® PFA P2Y, has been specifically developed to monitor patients' response to drugs inhibiting the platelet P2Y12 receptor for ADP. In this study, we compared the ability of INNOVANCE® PFA P2Y to detect congenital defects of the platelet P2Y12 receptor to that of standard cartridge formulations currently in clinical use.
Thrombosis research.Thromb Res.2014 Feb;133(2):254-6. doi: 10.1016/j.thromres.2013.11.022. Epub 2013 Dec 1.
INTRODUCTION: The platelet function analyzer (PFA)-100® is used in clinical practice to screen patients with bleeding diathesis and suspected defects of primary hemostasis. A new cartridge, INNOVANCE® PFA P2Y, has been specifically developed to monitor patients' response to drugs inhibiting the pl
PMID 24331208

Japanese Journal

ラットにおける血液流動性と活性酸素動態に対する漢方薬の影響

石川慎太郎,久保哲也,砂川正隆 [他],俵積田ゆかり,佐藤孝雄,石野尚吾,久光正
日本東洋醫學雜誌 = Japanese journal of oriental medicine 62(3), 337-346, 2011-05-20
瘀血の状態では，血液が鬱滞することから腫脹や疼痛などの障害が現れる。瘀血は循環障害と捉えられ，血管抵抗性と血液流動性の側面から研究されてきた。血液流動性の変動要因には血球および血漿成分があり，その変動に活性酸素が深く関わっていると考えられている。今回，ラットに漢方薬（当帰芍薬散，柴胡加竜骨牡蛎湯，桃核承気湯，桂枝茯苓丸，十全大補湯）を投与して活性酸素動態と血液流動性への …
NAID 10029129535

初期肝障害期における血液流動性の変化

安齋勉,石川慎太郎,石川貴子 [他],池谷洋一,酒井健,本田豊,村田健三郎,米山早苗,砂川正隆,佐藤孝雄,久光正
昭和医学会雑誌 71(6), 602-609, 2011
非アルコール依存性脂肪性肝炎（NASH）は，通常，無症候性の肝疾患である．NASHでは肝細胞の炎症と傷害が繰り返され，その結果肝細胞の脂肪変性，さらには線維化が進行，肝硬変へと進展する．一方，進行性の肝炎あるいは肝癌において血小板機能障害をきたすことが複数報告されているが，NASHのような初期の肝臓障害（Early-Hepatopathy: EH）における血小板機能と血液流動性に関してほとんど検討 …
NAID 130002150108

Comparison of Triple Antiplatelet Therapy Including Triflusal and Conventional Dual Therapy in Patients Who Underwent Drug-Eluting Stent Implantation

Suh Jung-Won,Kim Song-Yi,Park Jin-Shik,Kim Yong-Seok,Kang Hyun-Jae,Koo Bon-Kwon,Kim Hyo-Soo
International Heart Journal 50(6), 701-709, 2009
… object of this study was to evaluate the efficacy of additional use of triflusal in patients who underwent drug-eluting stent implantation.First, we prospectively tested platelet function with a rapid platelet function analyzer (VerifyNow®-Aspirin) in patients with stable angina (male, age, 61.6 ± 8.3, body weight, 69.3 ± 11.2 kg) who maintained dual (aspirin 100 mg and clopidogrel 75 mg per day, n = 23) or triple (aspirin 100 mg, …
NAID 130000120853

「PFA-100」

　　[★]

同: platelet function analyzer

「function」

　　[★]

n.

機能、(数学)関数、(化学)官能基

survival as a function of HbA1c in people with type 2 diabetes HbA1cの機能を考慮（指標に）した2型糖尿病の患者の生存（予後）

Figure 2A shows survival as a function of device removal during index hpspitalization, censored at 1 year or date of last contact. (Figure2Aはは最初の入院中における心臓デバイス除去に関する生存曲線で退院後1年もしくは最後の接触で打ち切っている)