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a salt or ester of pyrophosphoric acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/06 10:01:45」(JST)

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Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.

It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.

It plays a role in transferring phospho-ribose groups in several reactions:

Enzyme	Reactant	Product
adenine phosphoribosyltransferase	adenine	AMP
hypoxanthine-guanine phosphoribosyltransferase	guanine	GMP
hypoxanthine-guanine phosphoribosyltransferase	hypoxanthine	IMP
orotate phosphoribosyltransferase	orotate	OMP
uracil phosphoribosyltransferase	uracil	UMP

In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.

Increased PRPP

Increased levels of PRPP is characterized by the overproduction and accumulation of uric acid leading to hyperuricemia and hyperuricosuria. It is one of the causes of gout.

Increased levels of PRPP are present in Lesch-Nyhan Syndrome. Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate used by HGPRT during purine salvage.

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「ヌクレオチド」

Phosphoribosyl pyrophosphate
Names
	Other names 5-phospho-alpha-D-ribose 1-diphosphate
Identifiers
CAS Number	7540-64-9 ;
3D model (Jmol)	Interactive image;
ChEBI	CHEBI:17111 ;
ChemSpider	7062 ;
DrugBank	DB01632 ;
MeSH	Phosphoribosyl+pyrophosphate
PubChem CID	7339;
	InChI InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1 Key: PQGCEDQWHSBAJP-TXICZTDVSA-N ; InChI=1/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1 Key: PQGCEDQWHSBAJP-TXICZTDVBW ;
	SMILES O=P(O[C@H]1O[C@@H]([C@@H](O)[C@H]1O)COP(=O)(O)O)(O)OP(=O)(O)O ;
Properties
Chemical formula	C5H13O14P3
Molar mass	390.07 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: nucleotide
関: ヌクレオチド

核酸塩基+糖+リン酸
ヌクレオシドの糖の部分に1個以上のリン酸基がエステル結合した物質

生合成

De novo pathway

phosphoribosyl pyrophosphate + uridylate→…→nucleptode

アミノプテリンが途中の合成系路を阻害する　←　モノクローナル抗体の作成における選抜に利用される (関：HAT培地)

Salvage pathway]

2通りの経路がある
1. thymidine→…→nucleptode

thymidine kinase(TK)が触媒

2. hypoxanthine→…→nucleptode

hupoxanthine guanine phosphoribosyl transferase(HGPRT)が関与

「5-ホスホリボシル1α-二リン酸」

　　[★]

英: phosphoribosylpyrophosphate,5-phosphoribosyl 1-pyrophosphate ,PRPP
同: 5-ホスホリボシル1-ピロリン酸、ホスホリボシルピロリン酸 phosphoribosyl pyrophosphate、5-ホスホリボシル1-二リン酸 5-phosphoribosyl 1-diphosphate

図：FB.470
dNTP合成基質
イノシトール一リン酸(IMP)合成系路の中間物質

D-リボース5-リン酸より合成される

「phosphoribosyl pyrophosphate synthetase」

　　[★]

ホスホリボシルピロリン酸合成酵素、ホスホリボシルピロリン酸シンテターゼ

関: PRPP synthetase、ribose-phosphate pyrophosphokinase

「pyrophosphate」

　　[★] ピロリン酸、二リン酸

関: bisphosphate、diphosphate、diphosphoric acid、PPi

リンク元	「ヌクレオチド」「5-ホスホリボシル1α-二リン酸」
拡張検索	「phosphoribosyl pyrophosphate synthetase」
関連記事	「pyrophosphate」

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案内

案内

phosphoribosyl pyrophosphate