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Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.

Cookson TV1, Evans GL2, Castell A2, Baker EN2, Lott JS2, Parker EJ1.
Biochemistry.Biochemistry.2015 Oct 6;54(39):6082-92. doi: 10.1021/acs.biochem.5b00612.
Anthranilate phosphoribosyltransferase (AnPRT) is essential for the biosynthesis of tryptophan in Mycobacterium tuberculosis (Mtb). This enzyme catalyzes the second committed step in tryptophan biosynthesis, the Mg(2+)-dependent reaction between 5'-phosphoribosyl-1'-pyrophosphate (PRPP) and anthrani
PMID 26356348

Pisithkul T1, Jacobson TB2, O'Brien TJ2, Stevenson DM3, Amador-Noguez D4.
Applied and environmental microbiology.Appl Environ Microbiol.2015 Sep 1;81(17):5761-72. doi: 10.1128/AEM.01324-15. Epub 2015 Jun 12.
An outstanding challenge toward efficient production of biofuels and value-added chemicals from plant biomass is the impact that lignocellulose-derived inhibitors have on microbial fermentations. Elucidating the mechanisms that underlie their toxicity is critical for developing strategies to overcom
PMID 26070680

Strategy for enhancing adenosine production under the guidance of transcriptional and metabolite pool analysis.

Zhang C1, Du S, Liu Y, Xie X, Xu Q, Chen N.
Biotechnology letters.Biotechnol Lett.2015 Jul;37(7):1361-9. doi: 10.1007/s10529-015-1801-9. Epub 2015 Feb 28.
OBJECTIVES: To rationally identify targets for enhancing adenosine production, transcription level of genes involved in adenosine synthesis of Bacillus subtilis XGL was detected during the fermentation process, complemented with metabolite pool analysis.RESULTS: PurR-regulated genes (pur operon and
PMID 25724720

Identification of Endogenous Surrogate Ligands for Human P2Y Receptors Through an In Silico Search

Hiramoto Takeshi,Nonaka Yosuke,Inoue Kazuko [他],YAMAMOTO Takefumi,OMATSU (KANBE) Mariko,MATSUURA Hiroshi,GOHDA Keigo,FUJITA Norihisa
Journal of pharmacological sciences 95(1), 81-93, 2004-05-20
… We have previously constructed the 3D structure of human P2Y1 (hP2Y1) receptor, a GPCR, by homology modeling with the 3D structure of bovine rhodopsin as a template. … In the present study, we have employed an in silico screening for compounds that could bind to the hP2Y1-receptor model using AutoDock 3.0. …
NAID 10013054586

田鶴谷惠子,田中敬子,山田和子 [他],熊岡煕
ビタミン 73(7), 373-378, 1999-07-25
… These results suggested that the pyrimidine was synthesized from 5-aminoimidazole ribonucleotide (AIR) same as the route under aerobic conditions. … However, the two precursors from 5-phosphoribosyl-1-pyrophosphate to AIR in the purine nucleotide biosynthesis could be changed under anaerobic conditions. …
NAID 110002843877

Enzymes identified using genomic DNA sequences suggest some atypical characteristics of de novo biosynthesis of purines in archaebacteria

Koike Hideaki,Kawashima Tsuyoshi,Suzuki Masashi
Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 75(9), 263-268, 1999
… By the identified enzymes of Aeropyrum pernix, no step is expected to be mediated in the pathway leading to IMP, starting from the initial metabolic precursors, 5-phosphoribosyl-1-pyrophosphate and glutamine. …
NAID 130000903769