関: phosphorylcholine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/01 22:49:31」(JST)

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Not to be confused with phosphatidylcholine.

Phosphocholine is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP. Phosphocholine is a molecule found, for example, in lecithin.

It is also used by nematodes and human placentas as a posttranslational modification to suppress an immune response by their hosts.^[1]^[2]

It is also one of the binding targets of C-reactive protein (CRP).^[3] Thus, when a cell is damaged, CRP binds to phosphocholine, beginning the recognition and phagocytotic immunologic response.

Phosphocholine is a natural constituent of hens' eggs (and many other eggs) often used in biomimetic membrane studies.^[4]

References

^ Lovell TM, Woods RJ, Butlin DJ, et al. (September 2007). "Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides". J. Mol. Endocrinol. 39 (3): 189–98. doi:10.1677/JME-07-0007. PMC 2189575. PMID 17766644.
^ "Placenta 'fools body's defences'". BBC News. 2007-11-10. Retrieved 2010-05-22.
^ Thompson D, Pepys MB, Wood SP. (1999). "The physiological structure of human C-reactive protein and its complex with phosphocholine.". Structure 7 (2): 169–77. doi:10.1016/S0969-2126(99)80023-9. PMID 10368284.
^ Rose L, Jenkins ATA (2006). "The effect of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes". Bioelectrochem. 70 (2): 387–93. doi:10.1016/j.bioelechem.2006.05.009. PMID 16875886.

External links

Phosphocholine 3D Structure Viewer

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NAID 10028046236

「コリンリン酸」

Phosphocholine
Names
	Other names Choline phosphate
Identifiers
CAS Number	107-73-3
ChemSpider	119298
	InChI InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9) Key: YHHSONZFOIEMCP-UHFFFAOYSA-N ; InChI=1/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9) Key: YHHSONZFOIEMCP-UHFFFAOYAD ;
Jmol interactive 3D	Image
MeSH	Phosphocholine
PubChem	1014
	SMILES C[N+](C)(C)CCOP(O)(O)=O ;
Properties
Chemical formula	C5H15NO4P+
Molar mass	184.151 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: phosphocholine、phosphorylcholine
関: ホスホコリン、ホスホリルコリン

「ホスホコリン」

　　[★]

英: [[]]
同: phosphocholine
関: [[]]

同: phosphocholine

「1-alkyl-2-acetylglycerophosphocholine esterase」

　　[★]

1-アルキル-2-アセチルグリセロホスホコリンエステラーゼ

関: lipoprotein-associated phospholipase A2、Lp-PLA2、PAF acetylhydrolase

「1-acylglycerophosphocholine O-acyltransferase」

　　[★]

1-アシルグリセロホスホコリン-O-アシルトランスフェラーゼ

「alkylphosphocholines」

　　[★] アルキルホスホコリン APCs

「alkylphosphocholine」

　　[★] アルキルホスホコリン

[1] Lovell TM, Woods RJ, Butlin DJ, et al. (September 2007). "Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides". J. Mol. Endocrinol. 39 (3): 189–98. doi:10.1677/JME-07-0007. PMC 2189575. PMID 17766644.

[2] "Placenta 'fools body's defences'". BBC News. 2007-11-10. Retrieved 2010-05-22.

[3] Thompson D, Pepys MB, Wood SP. (1999). "The physiological structure of human C-reactive protein and its complex with phosphocholine.". Structure 7 (2): 169–77. doi:10.1016/S0969-2126(99)80023-9. PMID 10368284.

[4] Rose L, Jenkins ATA (2006). "The effect of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes". Bioelectrochem. 70 (2): 387–93. doi:10.1016/j.bioelechem.2006.05.009. PMID 16875886.

リンク元	「コリンリン酸」「ホスホコリン」
拡張検索	「1-alkyl-2-acetylglycerophosphocholine esterase」「1-acylglycerophosphocholine O-acyltransferase」「alkylphosphocholines」「alkylphosphocholine」

匿名

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案内

案内

phosphocholine