1-acylglycerophosphocholine O-acyltransferase

1-アシルグリセロホスホコリン-O-アシルトランスフェラーゼ

WordNet

1. the 15th letter of the Roman alphabet (同)o
2. the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O

PrepTutorEJDIC

1. 《呼び掛けの名前の前につけて》『おお』,あ / (驚き・恐れ・喜び・苦痛などを表して)『おお』,ああ,まあ / 《肯定・否定を強めて》
2. oxygenの化学記号
3. ohmオーム / Old
4. osmiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/13 14:53:31」(JST)

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1-acylglycerophosphocholine O-acyltransferase
Identifiers
EC number	2.3.1.23
CAS number	9027-64-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.23) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine CoA + 1,2-diacyl-sn-glycero-3-phosphocholine

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

• Bell RM, Coleman RA (1980). "Enzymes of glycerolipid synthesis in eukaryotes". Annu. Rev. Biochem. 49: 459–87. doi:10.1146/annurev.bi.49.070180.002331. PMID 6250446. 
• Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine". Biochim. Biophys. Acta. 152 (3): 645–8. PMID 5661029. 
• Miki Y, Hosaka K, Yamashita S, Handa H, Numa S (1977). "Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes". Eur. J. Biochem. 81 (3): 433–41. doi:10.1111/j.1432-1033.1977.tb11968.x. PMID 598375. 
• van den Bosch H, van Golde LM, Eibl H, van Deenen LL (1967). "The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes". Biochim. Biophys. Acta. 144 (3): 613–23. PMID 6078124. 

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English Journal

• Lysophosphatidylcholine acyltransferase 1 is downregulated by hepatitis C virus: impact on production of lipo-viro-particles.

• Beilstein F1,2, Lemasson M3, Pène V3, Rainteau D4, Demignot S1,2, Rosenberg AR3,5.
• Gut.Gut.2017 Dec;66(12):2160-2169. doi: 10.1136/gutjnl-2016-311508. Epub 2016 Aug 31.
• PMID 27582510

• The Arabidopsis thaliana lysophospholipid acyltransferase At1g78690p acylates lysocardiolipins.

• Moncada RM1, Blackshear KJ1, Garrett TA2.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2017 Nov 4;493(1):340-345. doi: 10.1016/j.bbrc.2017.09.021. Epub 2017 Sep 6.
• PMID 28888983

• ER phospholipid composition modulates lipogenesis during feeding and in obesity.

• Rong X1, Wang B1, Palladino EN2, de Aguiar Vallim TQ3, Ford DA2, Tontonoz P1,4,5.
• The Journal of clinical investigation.J Clin Invest.2017 Oct 2;127(10):3640-3651. doi: 10.1172/JCI93616. Epub 2017 Aug 28.
• PMID 28846071

Japanese Journal

• Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats

• Journal of Pharmacological Sciences 116(4), 362-372, 2011-08
• NAID 120005520704

Related Links

• 1-Acylglycerophosphocholine O-acyltransferase - Springer

EC number 2.3.1.23 Systematic name acyl-CoA:l-acyl-sn-glycero-3-phosphocholine O-acyltransferase Recommended name 1-acylglycerophosphocholine O-acyltransferase Synonyms l-acyl-sn-glycero-3-phosphocholine ...

• 1-Acylglycerophosphocholine O-Acyltransferase ...

1-Acylglycerophosphocholine O-Acyltransferase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: 1-Acylglycerophosphocholine O-Acyltransferase

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★リンクテーブル★

リンク元	「1-アシルグリセロホスホコリン-O-アシルトランスフェラーゼ」
関連記事	「acyltransferase」「O」「Os」

「1-アシルグリセロホスホコリン-O-アシルトランスフェラーゼ」

　　[★]

英

1-acylglycerophosphocholine O-acyltransferase

「acyltransferase」

　　[★]

アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素

関

transacylase

「O」

　　[★]

同

食道入口部

　 　 　 　 　

「Os」

　　[★] オスミウム osmium