WordNet
- determine the order of constituents in; "They sequenced the human genome"
- a following of one thing after another in time; "the doctor saw a sequence of patients" (同)chronological sequence, succession, successiveness, chronological succession
- film consisting of a succession of related shots that develop a given subject in a movie (同)episode
- serial arrangement in which things follow in logical order or a recurrent pattern; "the sequence of names was alphabetical"; "he invented a technique to determine the sequence of base pairs in DNA"
- several repetitions of a melodic phrase in different keys
- arrange in a sequence
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- showing favoritism
- being or affecting only a part; not total; "a partial description of the suspect"; "partial collapse"; "a partial eclipse"; "a partial monopoly"; "partial immunity"
- pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
- the radical -NH2 (同)amino_group
PrepTutorEJDIC
- 〈U〉〈C〉(時間の上の,また因果関係のつながりによる)『連続』,続き / 〈C〉《a~》(…の)一連のもの《+『of』+『名』》 / 〈U〉(起こる)『順序』(order),筋道 / 〈C〉(…に対する)結果《+『to』+『名』》
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- (また『part』)『一部分の』,部分的な;不完全な / 不公平な,偏った / 《補語にのみ用いて》(…が)特に好きで《+『to』+『名』》
- 配列,接続;(特に時間の)調整
UpToDate Contents
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English Journal
- Cyclic peptide analogs of 558-565 epitope of A2 subunit of Factor VIII prolong aPTT. Toward a novel synthesis of anticoagulants.
- Anastasopoulos C1, Sarigiannis Y, Stavropoulos G.Author information 1Department of Chemistry, University of Patras, Patras, Greece.AbstractNovel anticoagulant therapies target specific clotting factors in blood coagulation cascade. Inhibition of the blood coagulation through Factor VIII-Factor IX interaction represents an attractive approach for the treatment and prevention of diseases caused by thrombosis. Our research efforts are continued by the synthesis and biological evaluation of cyclic, head to tail peptides, analogs of the 558-565 sequence of the A2 subunit of FVIII, aiming at the efficient inhibition of Factor VIIIa-Factor IXa interaction. The analogs were synthesized on solid phase using the acid labile 2-chlorotrityl chloride resin, while their anticoagulant activities were examined in vitro by monitoring activated partial thromboplastin time and the inhibition of Factor VIII activity. The results reveal that these peptides provide bases for the development of new anticoagulant agents.
- Amino acids.Amino Acids.2014 Apr;46(4):1087-96. doi: 10.1007/s00726-014-1673-7. Epub 2014 Jan 25.
- Novel anticoagulant therapies target specific clotting factors in blood coagulation cascade. Inhibition of the blood coagulation through Factor VIII-Factor IX interaction represents an attractive approach for the treatment and prevention of diseases caused by thrombosis. Our research efforts are con
- PMID 24464027
- Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: relationship with multiple forms of drug ketone reductases.
- Endo S1, Matsunaga T, Arai Y, Ikari A, Tajima K, El-Kabbani O, Yamano S, Hara A, Kitade Y.Author information 1Gifu Pharmaceutical University, Gifu, Japan (S.E., T.M., Y.A., A.I.); Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan (K.T.); Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia (O.E.); Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan (S.Y.); and Faculty of Engineering (A.H., Y.K.), Gifu University, Gifu, Japan.AbstractMultiple forms of reductases for several drug ketones were isolated from rabbit liver, but their interrelationship and physiologic roles remain unknown. We isolated cDNAs for four aldo-keto reductases (AKR1C30, AKR1C31, AKR1C32, and AKR1C33), which share high amino acid sequence identity with the partial sequences of two rabbit naloxone reductases. The four recombinant enzymes reduced a variety of carbonyl compounds, including endogenous α-dicarbonyls (e.g., isatin and diacetyl), aldehydes (e.g., farnesal and 4-oxo-2-nonenal), and ketosteroids. They differed in specificity for drug ketones and ketosteroids. Although daunorubicin and befunolol were common substrates of all of the enzymes, AKR enzymes specifically reduced naloxone (AKR1C30, AKR1C32, and AKR1C33), metyrapone (AKR1C32 and AKR1C33), loxoprofen (AKR1C31 and AKR1C32), ketotifen (AKR1C30), and naltrexone and fenofibric acid (AKR1C33). AKR1C30 reduced only 17-keto-5β-androstanes, whereas the other enzymes were active toward 3-, 17-, and 20-ketosteroids, and AKR1C33 further reduced 3-keto groups of bile acids and 7α-hydroxy-5β-cholestanes. In addition, AKR1C30, AKR1C31, AKR1C32, and AKR1C33 were selectively inhibited by carbenoxolone, baccharin, phenolphthalein, and zearalenone, respectively. The mRNAs for the four enzymes were ubiquitously expressed in male rabbit tissues, in which highly expressed tissues were the brain, heart, liver, kidney, intestine, colon, and testis (for AKR1C30 and AKR1C31); brain, heart, liver, kidney, testis, lung, and adrenal gland (for AKR1C32); and liver and intestine (for AKR1C33). Thus, the four enzymes correspond to the multiple drug ketone reductases, and may function in the metabolisms of steroids, isatin and reactive carbonyl compounds, and bile acid synthesis.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Apr;42(4):803-12. doi: 10.1124/dmd.113.056044. Epub 2014 Feb 7.
- Multiple forms of reductases for several drug ketones were isolated from rabbit liver, but their interrelationship and physiologic roles remain unknown. We isolated cDNAs for four aldo-keto reductases (AKR1C30, AKR1C31, AKR1C32, and AKR1C33), which share high amino acid sequence identity with the pa
- PMID 24510382
- Predicting essential genes in prokaryotic genomes using a linear method: ZUPLS.
- Song K1, Tong T, Wu F.Author information 1School of Chemical Engineering and Technology, Tianjin University, 92 Weijin Road, Nankai district, Tianjin, 300072, China. ksong@tju.edu.cn tptong@tju.edu.cn wufang@tju.edu.cn.AbstractAn effective linear method, ZUPLS, was developed to improve the accuracy and speed of prokaryotic essential gene identification. ZUPLS only uses the Z-curve and other sequence-based features. Such features can be calculated readily from the DNA/amino acid sequences. Therefore, no well-studied biological network knowledge is required for using ZUPLS. This significantly simplifies essential gene identification, especially for newly sequenced species. ZUPLS can also select necessary features automatically by embedding the uninformative variable elimination tool into the partial least squares classifier. No optimized modelling parameters are needed. ZUPLS has been used, herein, to predict essential genes of 12 remotely related prokaryotes to test its performance. The cross-organism predictions yielded AUC (Area Under the Curve) scores between 0.8042 and 0.9319 by using E. coli genes as the training samples. Similarly, ZUPLS achieved AUC scores between 0.8111 and 0.9371 by using B. subtilis genes as the training samples. We also compared it with the best available results of the existing approaches for further testing. The improvement of the AUC score in predicting B. subtilis essential genes using E. coli genes was 0.13. Additionally, in predicting E. coli essential genes using P. aeruginosa genes, the significant improvement was 0.10. Similarly, the exceptional improvement of the average accuracy of M. pulmonis using M. genitalium and M. pulmonis genes was 14.7%. The combined superior feature extraction and selection power of ZUPLS enable it to give reliable prediction of essential genes for both Gram-positive/negative organisms and rich/poor culture media.
- Integrative biology : quantitative biosciences from nano to macro.Integr Biol (Camb).2014 Apr 1;6(4):460-9. doi: 10.1039/c3ib40241j. Epub 2014 Mar 7.
- An effective linear method, ZUPLS, was developed to improve the accuracy and speed of prokaryotic essential gene identification. ZUPLS only uses the Z-curve and other sequence-based features. Such features can be calculated readily from the DNA/amino acid sequences. Therefore, no well-studied biolog
- PMID 24603751
Japanese Journal
- Phylogenetic analysis of avian paramyxovirus serotype-1 in pigeons in Japan
- Molecular epidemiology and phylogenetic analysis of diverse bovine astroviruses associated with diarrhea in cattle and water buffalo calves in China
- The shoot of Ranunculus nipponicus var. submersus, a submerged vascular plant, can actively take up nitrate from cool water
Related Links
- Isolation and a partial amino acid sequence of insulin from the islet tissue of cod ( Gadus callarias). P. T. Grant and K. B. M. Reid. Natural Environment Research Council Fisheries Biochemical Research Unit, University of Aberdeen, Torry, ...
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- 関
- a sequence of、arrange、arrangement、array、barrage、consecutive、consequence、constellation、continually、continue、continuous、order、ordinal、outcome、output、product、result、resultant、sequencing、sequential、serial、series、thread
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- 関
- division、in part、moiety、part、partially、partly、piece、portion、region
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- 関
- sequence