Paraxial mesoderm |
Transverse section of a chick embryo of forty-five hours’ incubation.
- Chordamesoderm: yellow, at notochord.
- Paraxial mesoderm: red, at somite.
- Intermediate mesoderm: purple, near Wolffian duct.
- Lateral plate mesoderm: purple, near "Somatic mesoderm" and "Splanchic mesoderm".
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Chick embryo of thirty-three hours’ incubation, viewed from the dorsal aspect. (Paraxial mesoderm labeled at left.)
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Details |
Latin |
mesoderma paraxiale |
Carnegie stage |
9 |
Gives rise to |
somitomere, head mesoderm |
Identifiers |
Gray's |
p.50 |
Code |
TE E5.0.2.1.0.0.3 |
Anatomical terminology |
Paraxial mesoderm, also known as presomitic or somitic mesoderm is the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites, blocks of tissue running along both sides of the neural tube, which form muscle and the tissues of the back, including connective tissue and the dermis.
Contents
- 1 Formation and somitogenesis
- 2 Derived tissues
- 3 See also
- 4 References
- 5 External links
Formation and somitogenesis
The paraxial and other regions of the mesoderm are thought to be specified by bone morphogenetic proteins, or BMPs, along an axis spanning from the center to the sides of the body. Members of the FGF family also play an important role, as does the WNT pathway. In particular, Noggin, a downstream target of the Wnt pathway, antagonizes BMP signaling, forming boundaries where antagonists meet and limiting this signaling to a particular region of the mesoderm. Together, these pathways provide the initial specification of the paraxial mesoderm and maintain this identity.[1]
The tissue undergoes convergent extension as the primitive streak regresses, or as the embryo gastrulates. The notochord extends from the base of the head to the tail; with it extend thick bands of paraxial mesoderm.[2]
As the primitive streak continues to regress, somites form from the paraxial mesoderm by "budding off" rostrally.
In certain model systems, it has been shown that the daughter cells of stem cell-like progenitor cells which come from the primitive streak or site of gastrulation migrate out and localize in the posterior paraxial mesoderm. As the primitive streak regresses and somites bud off anteriorly, new cells derived from these stem-cell like precursors constantly enter the posterior end of the paraxial mesoderm.[3][4]
Derived tissues
Many kinds of tissue derive from the segmented paraxial mesoderm by means of the somite. Among these are:
- the sclerotome, which forms cartilage,
- the syndotome, which forms tendons,
- the myotome, which forms skeletal muscle,
- the dermatome, which forms the dermis as well as skeletal muscle,
- and endothelial cells.
Head Mesoderm
A particular kind of tissue deriving from the paraxial mesoderm is the head mesoderm. This tissue derives from the unsegmented paraxial mesoderm and prechordal mesoderm. Tissues derived from the head mesoderm include connective tissue and the muscles of the face.
The head mesoderm forms through a separate signaling circuit than the segmented paraxial mesoderm, though also involving BMP and fibroblast growth factor (FGF) signaling. Here, retinoic acid interacts with these pathways.[5]
See also
- Somitomere
- Chordamesoderm
- Intermediate mesoderm
- Lateral plate mesoderm
- Mesenchyme
- Triploblasty
References
This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918)
- ^ Pourquié, O. (2001). "Vertebratesomitogenesis". Annual Review of Cell and Developmental Biology 17: 311–350. doi:10.1146/annurev.cellbio.17.1.311. PMID 11687492.
- ^ Gilbert, S.F. (2010). Developmental Biology (9th ed.). Sinauer Associates, Inc. pp. 413–415. ISBN 978-0-87893-384-6.
- ^ Cambray, N.; Wilson, V. (2007). "Two distinct sources for a population of maturing axial progenitors". Development 134 (15): 2829–2840. doi:10.1242/dev.02877. PMID 17611225.
- ^ Maroto, M.; Bone, R. A.; Dale, J. K. (2012). "Somitogenesis". Development 139 (14): 2453–2456. doi:10.1242/dev.069310. PMID 22736241.
- ^ Bothe, I.; Tenin, G.; Oseni, A.; Dietrich, S. (2011). "Dynamic control of head mesoderm patterning". Development 138 (13): 2807–2821. doi:10.1242/dev.062737. PMID 21652653.
External links
- Overview at nih.gov
- Diagram and overview at mcgill.ca
- Diagram at lww.com
Human embryogenesis in the first three weeks
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Week 1 |
- Fertilization
- Oocyte activation
- Zygote
- Cleavage
- Blastomere
- Morula
- Blastocoele
- Blastocyst
- Blastula
- Inner cell mass
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Week 2
(Bilaminar) |
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Week 3
(Trilaminar) |
Germ layers |
- Archenteron/Primitive streak
- Primitive pit
- Primitive knot/Blastopore
- Primitive groove
- Gastrula
- Regional specification
- Embryonic disc
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Ectoderm |
- Surface ectoderm
- Neuroectoderm
- Somatopleuric mesenchyme
- Neurulation
- Neural crest
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Endoderm |
- Splanchnopleuric mesenchyme
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Mesoderm |
- Axial mesoderm
- Paraxial
- Intermediate
- Lateral plate
- Intraembryonic coelom
- Splanchnopleuric mesenchyme
- Somatopleuric mesenchyme
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Index of developmental medicine
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Description |
- Embryology
- Cell lines
- Stem cells
- endoderm
- mesoderm
- ectoderm
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Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
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Cells in humans derived from mesoderm
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Paraxial |
Mesenchymal stem cell |
Osteochondroprogenitor cell |
- Bone (Osteoblast → Osteocyte)
- Cartilage (Chondroblast → Chondrocyte)
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Myofibroblast |
- Fat
- Muscle
- Myoblast → Myocyte
- Myosatellite cell
- Tendon cell
- Cardiac muscle cell
- Other
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Other |
- Digestive system
- Interstitial cell of Cajal
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Intermediate |
Renal stem cell |
- Angioblast → Endothelial cell
- Mesangial cell
- Intraglomerular
- Extraglomerular
- Juxtaglomerular cell
- Macula densa cell
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- Stromal cell → Interstitial cell → Telocytes
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- Simple epithelial cell → Podocyte
- Kidney proximal tubule brush border cell
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Reproductive system |
- Sertoli cell
- Leydig cell
- Granulosa cell
- Peg cell
- germ cells
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Lateral plate/
hemangioblast |
Hematopoietic stem cell |
- Lymphoid
- Lymphoblast
- see lymphocytes
- Myeloid
- CFU-GEMM
- see myeloid cells
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Circulatory system |
- Endothelial progenitor cell
- Endothelial colony forming cell
- Endothelial stem cell
- Angioblast/Mesoangioblast
- Pericyte
- Mural cell
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Index of developmental medicine
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Description |
- Embryology
- Cell lines
- Stem cells
- endoderm
- mesoderm
- ectoderm
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Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
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