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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/13 13:27:42」(JST)

English Journal

Synthesis, crystal structure, and properties of a double-helical zinc(II) coordination polymer with Ozagrel drug.

Yang WC, Zheng ZB, Sun HL, Wang KZ.SourceCollege of Chemistry and Chemical Engineering, Pingdingshan University, Pingdingshan, Henan 467002, China.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2012 Feb;86:187-90. Epub 2011 Oct 20.
By the reaction of Zn(OAc)(2)·2H(2)O with Ozagrel, (E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylic acid (Himpaa), a novel coordination polymer [Zn(impaa)(2)](n)(1) was synthesized and was characterized by IR, elemental analysis, single-crystal X-ray diffraction analysis, photoluminescence spectro
PMID 22078079

Thromboxane A2 synthetase inhibitor plus low dose aspirin : can it be a salvage treatment in acute stroke beyond thrombolytic time window.

An GH, Sim SY, Jwa CS, Kim GH, Lee JY, Kang JK.SourceDepartment of Neurosurgery, National Medical Center, Seoul, Korea.
Journal of Korean Neurosurgical Society.J Korean Neurosurg Soc.2011 Jul;50(1):1-5. Epub 2011 Jul 31.
OBJECTIVE: There is no proven regimen to reduce the severity of stroke in patients with acute cerebral infarction presenting beyond the thrombolytic time window. Ozagrel sodium, a selective thromboxane A2 synthetase inhibitor, has been known to suppress the development of infarction. The antiplatele
PMID 21892396

Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion.

Koumura A, Hamanaka J, Kawasaki K, Tsuruma K, Shimazawa M, Hozumi I, Inuzuka T, Hara H.SourceDepartment of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2011 Jul;338(1):337-44. Epub 2011 Apr 14.
Rho kinase (ROCK), one of the serine/threonine kinases, is involved in pathologic conditions, and its activation causes neuronal cell death. Fasudil, a selective ROCK inhibitor, has been reported to cause increased cerebral blood flow (CBF) in the ischemic brain and protect against neuronal cell dea
PMID 21493751

A Selective Thromboxane A_2 (TXA_2) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid-Induced Lung Injury in Guinea Pigs

ISHITSUKA Yoichi,MORIUCHI Hiroshi,ISOHAMA Yoichiro,TOKUNAGA Hidehiro,HATAMOTO Keita,KURITA Sumika,IRIKURA Mitsuru,IYAMA Ken-ichi,IRIE Tetsumi
Journal of pharmacological sciences 111(2), 211-215, 2009-10-20
NAID 10025739282

豊田一則
脳神経外科ジャーナル 18(7), 494-501, 2009-07-20
急性期脳梗塞患者への抗血栓療法として,アスピリンの使用が強く勧められる.わが国のガイドラインでは,国産薬であるオザグレルナトリウムやアルガトロバンも勧められている.その一方で,臨床の場でよく用いられるヘパリンの有用性は確立していない.慢性期の非心原性脳梗塞患者への再発予防には,抗凝固薬でなく抗血小板療法が勧められる.具体的な推奨薬は各国のガイドラインで少しずつ異なるが,わが国で現在使用可能な薬剤の …
NAID 110007333752

リンク元	「オザグレル」
拡張検索	「ozagrel sodium」

Ozagrel
Systematic (IUPAC) name
	(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]acrylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	82571-53-7
ATC code	None
PubChem	CID 5282440
UNII	L256JB984D
KEGG	D08327
ChEMBL	CHEMBL11662
Chemical data
Formula	C13H12N2O2
Mol. mass	228.24 g/mol
	SMILES C1=CC(=CC=C1CN2C=CN=C2)C=CC(=O)O;
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