neurilemoma

神経鞘腫

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/07 15:37:39」(JST)

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Schwannoma
Classification and external resources
Micrograph of a schwannoma showing both a cellular Antoni A area (center and right of image) and a loose paucicellular Antoni B area (left edge of image). HPS stain.
ICD-10	C72.4
ICD-9	225.1
ICD-O:	M9560/0
DiseasesDB	33713
MeSH	D009442

A schwannoma (also known as an "neurilemmoma," "neurinoma," "neurolemmoma," and "Schwann cell tumor") is a benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves.

Schwannomas are very homogeneous tumors, consisting only of Schwann cells. The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure (thereby possibly causing damage). Schwannomas are relatively slow growing. For reasons not yet understood, schwannomas are mostly benign and less than 1% become malignant, degenerating into a form of cancer known as neurofibrosarcoma.

Schwannomas can arise from a genetic disorder called neurofibromatosis. They are universally S-100 positive.

Schwannomas can be removed surgically. Recurrences after total removal are rare.

See also

• Intranodal palisaded myofibroblastoma
• List of inclusion bodies that aid in diagnosis of cutaneous conditions

Additional images

• Subcutaneous schwannoma

References

See also

• Neurofibroma
• Vestibular schwannoma (Acoustic neuroma)

UpToDate Contents

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• 1. 前庭神経鞘腫（聴神経腫） vestibular schwannoma acoustic neuroma
• 2. 神経線維腫症2型 neurofibromatosis type 2
• 3. 頭蓋に対する定位手術的照射の合併症 complications of cranial stereotactic radiosurgery
• 4. 突発性難聴 sudden sensorineural hearing loss
• 5. 耳鳴の病因および診断 etiology and diagnosis of tinnitus

English Journal

• Schwannoma (Neurilemmoma) on the Base of the Tongue: A Rare Clinical Case.

• Sharma S1, Rai G2.
• The American journal of case reports.Am J Case Rep.2016 Mar 28;17:203-6.
• BACKGROUND Schwannomas are slow-growing benign tumors. They can arise from any peripheral nerve, including the cranial nerves (except the olfactory and optic nerves), spinal nerves, and autonomic nerves. Schwannomas of the head and neck account for 25-40% of all cases. However, intra-oral schwannoma
• PMID 27018477

• Pancreatic schwannoma: A rare case and a brief literature review.

• Ercan M1, Aziret M2, Bal A1, Şentürk A1, Karaman K1, Kahyaoğlu Z3, Koçer HB1, Bostancı B1, Akoğlu M1.
• International journal of surgery case reports.Int J Surg Case Rep.2016 Mar 26;22:101-104. doi: 10.1016/j.ijscr.2016.03.014. [Epub ahead of print]
• INTRODUCTION: Pancreatic schwannoma (PS) is an extremly rare benign tumor. Less than 50 cases of pancreatic schwannoma have been described in the English literature over the past thirty years.PRESENTATION OF CASE REPORT: A 63-year-old female underwent left modified radical mastectomy 2 years ago due
• PMID 27084984

• IMAGES IN CLINICAL MEDICINE. Froin's Syndrome.

• Dancel R1, Shaban M1.
• The New England journal of medicine.N Engl J Med.2016 Mar 17;374(11):1076. doi: 10.1056/NEJMicm1509557.
• PMID 26981937

Japanese Journal

• 切除術を施行した神経鞘腫症例の検討

• 中部日本整形外科災害外科学会雑誌 57(3), 603-604, 2014
• NAID 130004677473

• 術前診断が困難であった膵周囲末梢神経由来の神経鞘腫の1例

• 日本外科系連合学会誌 37(5), 1023-1028, 2012-10-30
• NAID 10031129914

• 術前診断が困難であった膵周囲末梢神経由来の神経鞘腫の１例

• 日本外科系連合学会誌 37(5), 1023-1028, 2012
• NAID 130004515128

Related Links

• neurilemoma - Medical Dictionary - The Free Dictionary

neurilemoma. Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, 0.01 sec. neurilemoma /neu·ri·lem·o·ma/ (-lĕ-mo´mah) a tumor of a peripheral nerve sheath (neurilemma), the most common type of neurogenic tumor, usually benign ...

• Schwannoma (Neurilemoma) at CHB

Schwannoma, also called neurilemoma, is a benign tumor that can arise from any nerve in the body, although it tends to favor certain nerves located in the head and neck along with nerves that are involved with flexing in the upper and lower ...

Related Pictures

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★リンクテーブル★

リンク元	「神経鞘腫」「nerve sheath tumor」

「神経鞘腫」

　　[★]

英

neurinoma, neurilemoma

同

シュワン細胞腫 Schwannoma、シュワン腫

関

脳腫瘍

概念

• 良性腫瘍
• 原発性脳腫瘍全体の10%
• 神経鞘腫の約90%はCN VIII原発(聴神経鞘腫)。その中でも前庭神経に由来するものが多い。

疫学

• 30-60歳に好発
• 男女比=1:1.3-1.5
• 前庭神経(神経鞘腫の90%を占める)＞三叉神経＞舌咽・迷走・副神経、顔面神経、舌下神経、滑車神経

遺伝性

• 基本的にない。両側前庭神経鞘腫が見られる神経線維腫症2型(原因遺伝子マーリン)においては、常染色体優性遺伝である。

病理

• 薄い皮膜
• 柔らかい
• 黄白色、赤褐色で易出血性。
• Antoni A型とAntoni B型が混在

症状

• 1. 初発症状：難聴(言語識別能の低下、高音域での聴力低下)、耳鳴り。15%の症例で突発性難聴で初発。5%の症例でめまいで初発。
• 2. 進展して三叉神経を障害：角膜反射の消失。顔面神経は障害されにくい。
• 3. 進展して小脳、脳幹を障害：四肢の運動失調、歩行障害
• 4. 進展して第4脳室の閉塞、テント切痕部での髄液の通過障害：水頭症による頭蓋内圧亢進症状。
• 5. 下方に進展した場合：舌咽神経、迷走神経などの下位脳神経障害：嚥下障害

• ブルンス眼振 Bruns眼振：健側の注視で高頻度で小さな眼振、病側の注視で低頻度で大きな眼振。

検査

• 温度眼振検査
• 聴力検査

• 純音聴力検査、語音明瞭土建鎖

• 聴性誘発脳幹反応(ABR)

画像検査

• MRI

• T1：低信号
• T2：高信号
• Gd造影：均一に強く造影

「nerve sheath tumor」

　　[★]

• 神経鞘腫、神経鞘腫瘍

関

malignant peripheral nerve sheath tumor、MPNST、nerve sheath neoplasm、neurilemmoma、neurilemoma、neurinoma、peripheral nerve sheath tumor