benzoate 4-monooxygenase

安息香酸-4-モノオキシゲナーゼ

関

benzoate 4-hydroxylase

WordNet

1. any salt or ester of benzoic acid

PrepTutorEJDIC

1. 安息香酸の塩またはエステル

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/11 12:22:24」(JST)

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benzoate 4-monooxygenase
Identifiers
EC number	1.14.13.12
CAS number	39391-25-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI Protein search

In enzymology, a benzoate 4-monooxygenase (EC 1.14.13.12) is an enzyme that catalyzes the chemical reaction

benzoate + NADPH + H⁺ + O₂ 4-hydroxybenzoate + NADP⁺ + H₂O

The 4 substrates of this enzyme are benzoate, NADPH, H⁺, and O₂, whereas its 3 products are 4-hydroxybenzoate, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include benzoic acid 4-hydroxylase, benzoate 4-hydroxylase, benzoic 4-hydroxylase, benzoate-p-hydroxylase, and p-hydroxybenzoate hydroxylase. This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation. It has 3 cofactors: iron, Tetrahydrobiopterin, and Tetrahydropteridine.

References

• Reddy CC, Vaidyanathan CS (1975). "Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814)". Biochim. Biophys. Acta. 384 (1): 46–57. PMID 236777. 

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English Journal

• Antifungal activity of cinnamic acid derivatives involves inhibition of benzoate 4-hydroxylase (CYP53).

• Korošec B1, Sova M, Turk S, Kraševec N, Novak M, Lah L, Stojan J, Podobnik B, Berne S, Zupanec N, Bunc M, Gobec S, Komel R.
• Journal of applied microbiology.J Appl Microbiol.2014 Apr;116(4):955-66. doi: 10.1111/jam.12417. Epub 2014 Jan 2.
• AIMS: CYP53A15, from the sorghum pathogen Cochliobolus lunatus, is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to fungi, it is a promising drug target in fungal pathogens of other eukaryotes.METHODS AND RESULTS: I
• PMID 24314266

• Virtual screening yields inhibitors of novel antifungal drug target, benzoate 4-monooxygenase.

• Berne S1, Podobnik B, Zupanec N, Novak M, Kraševec N, Turk S, Korošec B, Lah L, Šuligoj E, Stojan J, Gobec S, Komel R.
• Journal of chemical information and modeling.J Chem Inf Model.2012 Nov 26;52(11):3053-63. doi: 10.1021/ci3004418. Epub 2012 Nov 8.
• Fungal CYP53 enzymes are highly conserved proteins, involved in phenolic detoxification, and have no homologues in higher eukaryotes, rendering them favorable drug targets. Aiming to discover novel CYP53 inhibitors, we employed two parallel virtual screening protocols and evaluated highest scoring h
• PMID 23092521

• Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase.

• Bailey LJ1, Acheson JF, McCoy JG, Elsen NL, Phillips GN Jr, Fox BG.
• Biochemistry.Biochemistry.2012 Feb 14;51(6):1101-13. doi: 10.1021/bi2018333. Epub 2012 Feb 2.
• Crystal structures of toluene 4-monooxygenase hydroxylase in complex with reaction products and effector protein reveal active site interactions leading to regiospecificity. Complexes with phenolic products yield an asymmetric μ-phenoxo-bridged diiron center and a shift of diiron ligand E231 into a
• PMID 22264099

Related Links

• 安息香酸-4-モノオキシゲナーゼ - Wikipedia

安息香酸-4-モノオキシゲナーゼ（benzoate 4-monooxygenase）は、安息香酸分解 酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 ... この酵素の基質は 安息香酸、NADPH、HとO2で、生成物は 4-ヒドロキシ安息香酸、NADP+とH2Oである 。

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★リンクテーブル★

リンク元	「benzoate 4-hydroxylase」「安息香酸-4-モノオキシゲナーゼ」
関連記事	「monooxygenases」「monooxygenase」

「benzoate 4-hydroxylase」

　　[★]

安息香酸-4-水酸化酵素、安息香酸-4-ヒドロキシラーゼ

関

benzoate 4-monooxygenase

「安息香酸-4-モノオキシゲナーゼ」

　　[★]

英

benzoate 4-monooxygenase

関

安息香酸-4-水酸化酵素

「monooxygenases」

　　[★]

関

See also Cytochrome P450 system

「monooxygenase」

　　[★] モノオキシゲナーゼ