WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
a complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug (同)Mutamycin

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carbonの化学記号
cesiumの化学記号
cadmiumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/15 03:44:57」(JST)

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Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage.

Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or LASIK; mitomycin C has also been shown to reduce fibrosis in strabismus surgery.^[1] The third is in esophageal and tracheal stenosis where application of mitomycin C onto the mucosa immediately following dilatation will decrease re-stenosis by decreasing the production of fibroblasts and scar tissue.

Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases. Both alkylations are sequence specific for a guanine nucleoside in the sequence 5'-CpG-3'.^[2] Potential bis-alkylating heterocylic quinones were synthetised in order to explore their antitumoral activities by bioreductive alkylation.^[3] Mitomycin is also used as a chemotherapeutic agent in glaucoma surgery.

References

^ Kersey JP, Vivian AJ (Jul–Sep 2008). "Mitomycin and amniotic membrane: a new method of reducing adhesions and fibrosis in strabismus surgery". Strabismus. pp. 116–118. doi:10.1080/09273970802405493. PMID 18788060. Missing or empty |url= (help)
^ Tomasz, Maria (September 1995). "Mitomycin C: small, fast and deadly (but very selective).". Chemistry and Biology. 2 (9): 575–579. doi:10.1016/1074-5521(95)90120-5. PMID 9383461.
^ Renault, J.; Baron, M; Mailliet, P.; et al. (1981). "Heterocyclic quinones 2. Quinoxaline-5,6-(and 5-8)-diones - Potential antitumoral agents". Eur. J. Med. Chem. 16 (6): 545–550.

UpToDate Contents

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1. マイトマイシン-Cの肺毒性 mitomycin c pulmonary toxicity
2. 筋層非浸潤性膀胱癌の治療 treatment of non muscle invasive bladder cancer
3. 非プラチナ製剤ベースの癌化学療法の神経学的合併症の概要 overview of neurologic complications of non platinum cancer chemotherapy
4. 悪性腹膜中皮腫：治療 malignant peritoneal mesothelioma treatment
5. 肛門癌の臨床的特徴、病期分類、および治療 clinical features staging and treatment of anal cancer

English Journal

Modification of cellular DNA by synthetic aziridinomitosenes.

Mallory CM1, Carfi RP2, Moon S3, Cornell KA4, Warner DL5.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Dec 1;23(23):7378-85. doi: 10.1016/j.bmc.2015.10.028. Epub 2015 Oct 21.
Two synthetic aziridinomitosenes (AZMs), Me-AZM and H-AZM, structurally related to mitomycin C (MC) were evaluated for their anticancer activity against six cancer cell lines (HeLa, Jurkat, T47D, HepG2, HL-60, and HuT-78) and tested for their DNA-modifying abilities in Jurkat cells. Cytotoxicity ass
PMID 26541587

Implementing Intensity-modulated Radiotherapy with Simultaneous Integrated Boost for Anal Cancer: 3 Year Outcomes at Two Sydney Institutions.

Yates A1, Carroll S2, Kneebone A3, Tse R2, Horvath L4, Byrne C5, Solomon M5, Hruby G3.
Clinical oncology (Royal College of Radiologists (Great Britain)).Clin Oncol (R Coll Radiol).2015 Dec;27(12):700-7. doi: 10.1016/j.clon.2015.08.006. Epub 2015 Sep 14.
AIMS: Modern chemoradiotherapy used for the treatment of anal cancer has significant acute toxicity. Intensity-modulated radiotherapy (IMRT) may reduce these side-effects. We report our experience implementing IMRT with simultaneous boost at the Sydney Cancer Centre and Royal North Shore Hospital.MA
PMID 26382849

The Effect of the UK Coordinating Centre for Cancer Research Anal Cancer Trial (ACT1) on Population-based Treatment and Survival for Squamous Cell Cancer of the Anus.

Downing A1, Morris EJ2, Aravani A2, Finan PJ3, Lawton S4, Thomas JD5, Sebag-Montefiore D6.
Clinical oncology (Royal College of Radiologists (Great Britain)).Clin Oncol (R Coll Radiol).2015 Dec;27(12):708-12. doi: 10.1016/j.clon.2015.06.019. Epub 2015 Jul 15.
Between 1987 and 1994, three randomised phase III trials showed that chemoradiotherapy with mitomycin C and 5-fluorouracil was superior to radiotherapy alone (ACT1, European Organization for Research and Treatment of Cancer) or radiotherapy with 5-fluorouracil (Radiation Therapy Oncology Group 87-04
PMID 26188917

Japanese Journal

マイトマイシンC併用初発翼状片手術前後での自発性瞬目の変化の検討 (特集第67回日本臨床眼科学会講演集(7))

山中行人,福岡秀記,鈴木一隆 [他]
臨床眼科 68(9), 1291-1295, 2014-09
NAID 40020190621

筋層非浸潤性膀胱癌に対する再発予防目的Mitomycin C膀胱内注入療法の検討

大杉治之,北村悠樹,眞鍋由美 [他]
泌尿器科紀要 = Acta urologica Japonica 60(8), 375-379, 2014-08
NAID 40020166152

筋層非浸潤性膀胱癌に対する再発予防目的Mitomycin C膀胱内注入療法の検討

大杉治之,北村悠樹,眞鍋由美,増田憲彦,伊東晴喜,三品睦輝,奥野博
泌尿器科紀要 = Acta urologica Japonica 60(8), 375-379, 2014-08
… Mitomycin C (MMC) is commonly used as adjuvant treatment for NMIBC. …
NAID 120005468368

Related Pictures

★リンクテーブル★

リンク元	「マイトマイシンC」「マイトマイシン」「MMC」
関連記事	「C」「Cs」「Cd」「c」

「マイトマイシンC」

Mitomycin C
Systematic (IUPAC) name
	{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate
Clinical data
Pregnancy; category	AU: D; US: D (Evidence of risk); ;
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Metabolism	Hepatic
Biological half-life	8–48 min
Identifiers
CAS Number	50-07-7
PubChem	CID 5746
IUPHAR/BPS	7089
DrugBank	DB00305
ChemSpider	5544
UNII	50SG953SK6
KEGG	C06681
ChEBI	CHEBI:27504
ChEMBL	CHEMBL105
Chemical data
Formula	C=15
Molar mass	154.17 g·mol−1
	SMILES CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N ;
	InChI InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1; ; Key:NWIBSHFKIJFRCO-WUDYKRTCSA-N ;
Physical data
Melting point	360 °C (680 °F)
Solubility in water	8.43 g L−1 mg/mL (20 °C)

　　[★]

英: mitomycin C mitomycin-C, MMC
商: マイトマイシン
関

添付文書

マイトマイシン注用10mg

http://www.info.pmda.go.jp/go/pack/4231400D2038_1_07/4231400D2038_1_07?view=body

-mitomycin C

同: MMC

「マイトマイシン」

　　[★]

英: mitomycin
ラ: mitomycinum
同: Mutamycin？？？
同: マイトマイシンC？？？
関: マイトマイシンC mitomycin C MMC

抗悪性腫瘍薬

抗生物質系：DNA鎖切断

「MMC」

　　[★]

「C」

　　[★]

炭素 carbon
シトシン cytosine
システイン cysteine
シチジン
セルシウス度摂氏 degrees Celsius degree C
産婦人科領域で「子宮外頚子宮外頚部 exocervix」を表現するための略語

「Cs」

　　[★] セシウム, caesium, cesium 　

「Cd」

　　[★] カドミウム

関: cadmium

「c」

　　[★]

光速, speed of light

[1] Kersey JP, Vivian AJ (Jul–Sep 2008). "Mitomycin and amniotic membrane: a new method of reducing adhesions and fibrosis in strabismus surgery". Strabismus. pp. 116–118. doi:10.1080/09273970802405493. PMID 18788060. Missing or empty |url= (help)

[Tomasz-2] Tomasz, Maria (September 1995). "Mitomycin C: small, fast and deadly (but very selective).". Chemistry and Biology. 2 (9): 575–579. doi:10.1016/1074-5521(95)90120-5. PMID 9383461.

[3] Renault, J.; Baron, M; Mailliet, P.; et al. (1981). "Heterocyclic quinones 2. Quinoxaline-5,6-(and 5-8)-diones - Potential antitumoral agents". Eur. J. Med. Chem. 16 (6): 545–550.

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案内

案内

mitomycin C